<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP04719

Description Mediator of RNA polymerase II transcription subunit 15
SequenceMATDENSWRTQNFRQSVIAKIDEAVQISGMPTSKNSIEMENHVFQKAKTKEEYLGFVARLILHVRELNSKKGAGGTAPGTAGSGNQGMPDPIGALQTLARQGTGNNQMMNMNGPGPNPQGIIPQQPANTATNLLQSLNQRPGQPITMQGMQSKMPGMGMMPAQTSGPISHLGAIQTMQTNAMLTQMNQMGQGNIPQQMNQMVPNQMGPITTGQMQQNMQTQMQNQLSNQIGNQISGSMSGIQTSMPQQMNQIAPGQLGPGQMQQQLSHMQRKQGEMINTGFPGPRNVTPNQFLGQSPSPSAPSPAGLGAPSSNQMVASPALVPSSSPQHAMMAGPQRSVGMAPSPSSSLNTPGGVGATPSPQQEDQAYRDKVRQLSKYVEPLRRMISKMGNEGNVDKLSKMKKLLEILSNPSKRMPLDTLLKCEVVLEKLDFKRNDASVGPPVTTLKEHHFFSPLLEAVSTHLQSPVVNHTLQRTFGPCLEALFGPEIKNLPPPLKKQKIEESLSEIPDVLQGEIARLDQRFKVSLDPAQQTGSKCIQLICWLDDRHLPCVPPVSVTVPADYPLTPPRCVMAPHEYATTFLCAVQKALNARITKLPRRFSVSQLLDTWEMSVRQASAPSQTPITASTVLMGL
Length632
PositionTail
OrganismHabropoda laboriosa
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Hymenoptera> Apocrita> Aculeata> Apoidea> Apidae> Habropoda.
Aromaticity0.03
Grand average of hydropathy-0.461
Instability index51.30
Isoelectric point9.41
Molecular weight68495.01
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP04719
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     225.76|      39|      39|     150|     188|       1
---------------------------------------------------------------------------
   93-  133 (47.57/15.51)	GALQTL.ARQG..TGNNQmmnM.NGPGPnP..QG.IIPQQPANTATNL
  134-  171 (57.15/20.18)	..LQSLnQRPGQPITMQG...M.QSKMP.G..MG.MMPAQTSGPISHL
  172-  210 (46.41/14.94)	GAIQTM.QTNAMLTQMNQ...MgQGNIPqQ..MNqMVPNQM.GPIT..
  270-  307 (37.70/10.69)	...QRK.QGEMINTGFPG...P.RNVTP.NqfLG.QSPSPSAPSPAGL
  356-  389 (36.93/10.31)	GATPSP.Q......QEDQ..aY.RDKVR.Q..LS.KYVEPLRRMISKM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      78.05|      21|      21|     218|     238|       2
---------------------------------------------------------------------------
  212-  230 (22.38/ 6.71)	.....GQMqqnMQTQMQNQLSNQI
  231-  252 (34.23/13.81)	GNQISGSM.sgIQTSMPQQM.NQI
  255-  267 (21.44/ 6.15)	GQLGPG........QMQQQLS...
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.26|      13|      70|     478|     494|       3
---------------------------------------------------------------------------
  454-  466 (21.39/11.14)	PLLEAV....STHLQSP
  478-  494 (20.87/22.99)	PCLEALfgpeIKNLPPP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.49|      15|      23|     308|     326|       4
---------------------------------------------------------------------------
  308-  326 (22.54/17.00)	GAPSSNQMVASPalvpSSS
  334-  348 (28.95/12.73)	GPQRSVGMAPSP....SSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      63.48|      18|      24|     515|     532|       6
---------------------------------------------------------------------------
  515-  532 (31.53/18.02)	IARLDQRFKVSLDPAQQT
  540-  557 (31.95/18.35)	ICWLDDRHLPCVPPVSVT
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP04719 with Med15 domain of Kingdom Metazoa
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