<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP04718

Description Cyclin-dependent kinase 8
SequenceMDYEFKLKTDTDRTKVEDLFEFEGCKVGRGTYGHVYKARRKEGVPDSELKSRPDTKDFGLKQIEGTGLSMSACREIALLRELKHVNVITLIRVFLSHIDRKVWLLFDFAEHDLWHIIKFHRAAKANKKPVMVPKGMVKSLLYQILDGNERGRVKIADMGFARLFNAPLKPLADLDPVVVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPYHHDQLDRIFNVMGFPLEKDWEDIKKMPEHPTLLKDFKRSNYANCSLTKYMDRHKIKPDSKAFNLLQKLLMMDPNKRITSEHSMQDAYFQEEPLPTQDIFAGCPIPYPKREFLTDDDTEEKTENKARQNQQQTVSTYIDLPLKLVYFLTNATKLQQQNQQQQGNGDHNHGQSAKRVRLNGPHGAPEFHQHQSHAMTHQQPPGMVYSTAQPTQPSNFHQRF
Length450
PositionKinase
OrganismHabropoda laboriosa
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Hymenoptera> Apocrita> Aculeata> Apoidea> Apidae> Habropoda.
Aromaticity0.10
Grand average of hydropathy-0.656
Instability index41.08
Isoelectric point8.76
Molecular weight52228.15
Publications









Function






Annotated function


GO - Cellular Component
GO - Biological Function
ATP binding	GO:0005524	IEA:InterPro
protein kinase activity	GO:0004672	IEA:InterPro

GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP04718
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      77.06|      21|      26|     399|     419|       1
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  399-  419 (39.72/24.70)	HGQSAKRVRLNG.PHGAPEFHQ
  427-  448 (37.34/22.81)	HQQPPGMVYSTAqPTQPSNFHQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     134.46|      42|     126|     200|     248|       2
---------------------------------------------------------------------------
  200-  248 (64.58/77.45)	DIWAiGCIFA....ELLTSEPifhcrQEDiKTSNPYHHDQLDRIFNVMGFPLE
  328-  373 (69.88/55.28)	DIFA.GCPIPypkrEFLTDDD.....TEE.KTENKARQNQQQTVSTYIDLPLK
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP04718 with CDK8 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) ATKLQQQNQQQQGNGDHNHGQSAKRVRLNGPHGAPEFHQHQSHAMTHQQPPGMVYSTAQPTQPSNFHQRF
381
450










Molecular Recognition Features






MoRF SequenceStartStop




1) AKRVRL
403
408