<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP04716

Description Mediator of RNA polymerase II transcription subunit 1
SequenceMDVANGQKPLSGQPSATGCSAMDKGKEWQMELLMEKLRSKASTFKSLVETAKNLRMAMLDKRFAIDSAEKSQLQKCLDTLQHSIKVTSLQSMVERLESLTRQLGLKFMMSGPQGTELFISSDMFFLEVLLEPTGVVKDVKIHHEGKNEQQSCDVLVSCLSRGDFLDFTVQLEGLASIYQLNADKKVKCKAFSALQSLEADLGILAQLQTFIKEPFNLVHKSPVGILERRRGGHAMKLTYFVSPYDLIDQENRTCDALNSEIVIKRKIGHSVTVCMEGSTAHKLPTSSIITVNRSPTGKNTPSYAPLTGTNSSVLPACFVLKLAKKMPMCMELVRRIQKVTELECGDISAPHPLLSLIIQHTSEGQLDCRNNRGLYITLPDQQHCYFMTENRNMEGVLVCSIPFTHPAHVPQILVYLRQQALFNSLIASCVRSMARQDPEHATIFEVSALSWQHISVSLEHPFEETMATAELDLTDISALKCKLYGISITNTEQTSDLTGKVLQKCLSIPLTMRILMKSWESRDSLSTMNNLNSGNGNYNVNLGSGKDQNNAGTENSIGFPSYSGQSDTTTTAMLNPLQLGALLGQAKNSMSNPMNERTKKARKRKTADGIWRSPKRKGDESAEILLESSSSDSTPLGTPTGGRENLNETRTSTPTSATSLTSGLDFSNLDPTDILGTDKSSDYDIDNESEITEVHDLQDVEELIKRDRKSRKREEKKSPIIFEENKSLVPPSVSITPISSSSLGQTTNYNSVLTGMGLERRPGIEIIPIASSPQTTLPSSITITPIAGPTQSKSLTDERRERKSSKGKSTEDKGKLEKRRKRKREDSPMGPPPDKIPSKQDPLSKPVSVSIKPTESPPNLSSRPSSPATTLRKFSPSPTHTSPLALVGKSSPTLKQSTNKAVQSPKHSPVYSSSPKHTPVPASVSPKHGTSSPKHGNSASTGKPSMSALKSAANSPSSKTTDSGQSKIKSSSSSSSKDSNREKERKTSSLAFGGSSGHQSPKTKSSSDSKSGTNLKLSSSSASVATGTSSGSSTSSTSISGNGSPKTHTGLKPGVSSGPASKKPPSQTSPKLSGSSSSGSGSGSGNKATLSGQKMSALKSISGSNSGSGNGAGGISVGGSGSSGLLSKSVMSSKSSSSSPKITSSGVTDLSRNRDKSRLSKSGDKSLFPSKGIGDTRKSSPSGLREESESERAFKLLAAHASMSNLSNLPNLPPQLVVEGLMKQLDTKFQIPKLSARANADSSDKKSEKLSMLPDSAKTLDNLAAKQTTEQGKLQTLSNTSTTASKTTSEDQSSQGRREHVQTKPDNLSMTSAASVINLGTDSTNNLLLPALSSSSSHDLDIPTNLSMQSTENEPRDKEPSMSRSNTQFLSSNINSTAAGKDDTSGSGPVMAVLPKVSDSQATSKPVYPTMMTTGTLTSGNGTSNSSSGNGGAESLNLSIKPASQPQQQQQQPPQVPSTGGSSSASSLGTTVSSEGSSCTMKVAGTELPSTTSQEAAEMLLDFSTPKDVAKSLNFTSIPERAMTQAASVRRNTPPPPPPAFPASPSVSVHIVKSPAPSPRVIPPSPHSASPCITDDELMDEALVGMGK
Length1588
PositionMiddle
OrganismHabropoda laboriosa
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Hymenoptera> Apocrita> Aculeata> Apoidea> Apidae> Habropoda.
Aromaticity0.03
Grand average of hydropathy-0.562
Instability index56.82
Isoelectric point9.27
Molecular weight168784.82
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP04716
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      76.29|      21|      23|    1071|    1092|       1
---------------------------------------------------------------------------
  912-  931 (26.67/ 6.64)	SS.SPKHTPVPASVSP.K.HG.TS
 1077- 1100 (22.51/ 7.27)	SSGSGSGSGNKATLSGqKmSAlKS
 1459- 1478 (27.11/ 6.88)	TGGSSSASSLGTTVSS.E..G.SS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     135.96|      26|      26|     853|     878|       2
---------------------------------------------------------------------------
  853-  878 (47.75/21.14)	PTESPPNLSSRPSSPATTLRKFSPSP
  880-  901 (27.18/ 7.80)	HT.SPLALVGK.SSP..TLKQSTNKA
  997- 1021 (34.02/12.24)	GHQSPKTKSSSDSKSGTNL.KLSSSS
 1119- 1139 (27.01/ 7.69)	GSGSSGLLSKSVMSS.....KSSSSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      95.31|      28|     496|     653|     690|       3
---------------------------------------------------------------------------
  662-  690 (46.48/36.85)	SGlDFSNLDPTDILGTDKSSDYDIDNESE
 1162- 1189 (48.83/19.85)	SG.DKSLFPSKGIGDTRKSSPSGLREESE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     151.27|      37|     496|    1034|    1070|       4
---------------------------------------------------------------------------
  938-  968 (36.94/10.00)	..SAS...TGKP.SMSALKSAANS.PSSKTTDSgQSKI
 1034- 1070 (67.52/24.53)	TSSTSISGNGSPKTHTGLKPGVSSGPASKKPPS.QTSP
 1413- 1445 (46.81/14.69)	TTGTLTSGNGTSNSSSG.NGGAESLNLSIKPAS.Q...
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     108.72|      26|      27|    1309|    1335|       6
---------------------------------------------------------------------------
 1309- 1335 (36.92/19.46)	SMTSAASVINLGTDSTNNlLLPALSSS
 1347- 1365 (32.04/12.86)	SMQSTE...NEPRDKE.....PSMSRS
 1375- 1400 (39.76/17.57)	NSTAAGKDDTSGSGPVMA.VLPKVSDS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.66|      16|      26|    1253|    1276|       7
---------------------------------------------------------------------------
 1249- 1269 (20.90/15.44)	KLSMLPDSAKTldnlaAKQTT
 1273- 1288 (25.77/16.27)	KLQTLSNTSTT.....ASKTT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.09|      21|      27|     448|     474|       8
---------------------------------------------------------------------------
  448-  474 (27.95/35.95)	ALSWQHISVSLEHPfEETMataelDLT
  478-  498 (36.14/24.67)	ALKCKLYGISITNT.EQTS.....DLT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     244.39|      53|     108|     596|     651|       9
---------------------------------------------------------------------------
  596-  648 (91.51/39.89)	ERTKKARKR..KTADGIWRSPKRKGDESAEILLESSSSDST........PLGTPTGGRENLNE
  705-  751 (68.26/27.07)	KRDRKSRKReeKKSPIIFEENKSLVPPSVSITPISSSS............LGQTT....NYNS
  754-  794 (38.63/12.95)	..TGMGLER..R..PGI............EIIPIASSPQTTlpssititPIAGPTQSKS....
  796-  832 (45.98/17.00)	..TDERRER..KSSKG..KSTEDKG..KLEKRRKRKREDS.........PMGPP.........
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      91.62|      27|      28|     192|     218|      12
---------------------------------------------------------------------------
  192-  218 (43.67/34.00)	SALQSLEADLGILAQLQTFIKEPFNLV
  221-  247 (47.95/38.19)	SPVGILERRRGGHAMKLTYFVSPYDLI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.28|      14|      28|      20|      33|      15
---------------------------------------------------------------------------
   20-   33 (25.08/17.76)	SAMDKGKEWQMELL
   46-   59 (22.21/14.84)	SLVETAKNLRMAML
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      70.33|      23|     427|      73|      99|      19
---------------------------------------------------------------------------
   73-   99 (31.08/29.63)	LQKCLD.TLQHSIKVTSLQSmveRlESL
  502-  525 (39.25/23.13)	LQKCLSiPLTMRILMKSWES...R.DSL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      33.67|      10|      17|     564|     576|      24
---------------------------------------------------------------------------
  564-  576 (14.30/15.88)	GQSDTTttaMLNP
  584-  593 (19.37/10.74)	GQAKNS...MSNP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      69.73|      21|      29|     138|     158|      27
---------------------------------------------------------------------------
  138-  158 (38.30/25.44)	DVKIHHEG..KNEQQSCDVLVSC
  166-  188 (31.43/19.58)	DFTVQLEGlaSIYQLNADKKVKC
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP04716 with Med1 domain of Kingdom Metazoa
Unable to open file!