<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP04713

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMTHPSHQTNGASLEDCHTNFFALTDLCGIKWKKLVWGEVAGDFGGTPLEDPVLSSFSRCLAGDILCVWRRVSATPATSGPATASATGAGIFDLGIAPSPAPPPLSLTAAKELWIFWYGEEPDLSGLVSPELIARESEQGSWESGLSYECRSLLFKALHNLIERCLLSRDFVRLGKWFVQPYDGFEKHRCSSSHLSFSFAFFVHGESTVCASVDVRQHPAVRHLTRACLQRTQTSQSGVKVILAPYGLAGTLTGPVGRTDSQLLEEWKHFYPINGSNIEAGLPPLVEVLVGGVRMRYPSCYVLVTDMDDTPPDTPLSPPSSPAKRVWAECTLSSPISASKTESSTEPGTWTFIDPTQKSSCTCSNHVEKQDIKYIGCRYTTPGGWKSLASSQVQRERVDKGGRRVVPFHRRSTTQWDACPSVPANAPRSILNRTEAPSTPPGGPPSYSRGPPTGGDCLPVPSVGSPGSPAPSPLPTPHSEPASVPPAEPTMPTLSPQPPPSHTNTAPPLTPSQGPKSTSSACNNQVHSPAAGPTLKRPVLASRECEDIYLENEQSLPWLYDYSTQEAWLNHPVKRFKESNSSPVNVRSNTLYPPINSQVPQSQTPKLEIKQEPNVNVGDCIGRRTDPYEFDATGEENGTGVDGLRRQRDDPTKPGSLFTSEGLQASYKDLDQIFDNSDPDTSSDETNLNQLQVQTPPESNRSSGLHEETRTDANRHNNRGVGVLRPEELSKMFPTPPSLEHNPVASPCQLNDPLMDQTELSVPQRPLRHLPDIYPNMGSPQEEPIDDWSYVFKPAPICKMVGSSKYAPLTNLPSQSLPPITLPSHCVYRPSWQCSPTSNNSDKPLPPTRPGSVQQQPCPPSPAPLGAPYRSTISGRPPPPPYDQPSPATSTTSSYLNKNLNSIEADTPGPTRAPESNSLIVNILLGDTALNIFRDHNFDSCSLCVCNAGPKVVGNIKGADAGVYLTHSWSSGALFQDDDQIRCSCGFSAVVNRRLAHKAGLFYEDEMEITGIAEDPAEKKKASLVAIACGGSKPSDGLDVIPPNVLELLREQCLIVQSSASSLYRASRIYASMKSYPMLAPTVNMLEFNDGNEVSLAALDQGKINGTHNERTNRVIGVHRWVFLRAKGPQCSGDIVRMMRALQPLLQDAVQKKCTTRMWEAPYTVAGPLTWRQFHRLAGRGTDDRCEPQPIPALVVGYDRDWLSLSPYALSYWEKLLLEPYAGPRDVAYVIVAPDSDCVINKVKSFFRELSTTYEICRLGRHTPISKALRDGILRVGKSSVQKQAKQPIDDWFKLLGENQLGELLRLYAQVCNHRLAPYLTQVIQDRSLLDPGDSQPTNKQQQQTTIPVTDTMPATPDVMTNKPESVEGENPRSDTPSSNTATNSNSNTGNTTPTSQTATIHTNTTSGPDEEEVEPPAVVVYLVEPFSLGGPEDPDRRRLAILALLRAYSAAVNSMPENIRSNINVQIISLESIMELGRARERRKIQDEMRALALNVFLQGRRLLNHNSTVKSLTGFGTAAAADLFLKSKDSYSNTLATIHQERNKAPYRLYAPAYVLAPLRAKSEAPESFGIAGPEECAVLYLSYCLSEDQSWLLAVATDDRGEIFETATINIDIPNRKRRKRASARRIGLQKLMDFILGVMSQGVSYNEKYQMNWLLSRKALLKASKHLKEICGQCSLLYPSAAPCVLSACLVSLEPDSTLRLMADQFTPDERFSQASVNCQLSTPQDVTCTHILVFPTSATTQSSQTAFQEQHINGPELGDDELFSALNDDMPEGMEGMGDFNDIFNVWPEPGAGGGQSPGGSPHRPEGSPLGGDGGGSGLGNHDGPGSPFPCSNTPRVAVAEQTEEVGTLLQQPLALGYLVSTAPTGRMPPWFWSACPHLEGICPVFLKNALHLHSPAIQQNSDDLLQQQSALTAHPLDSQYTTDVLRYVLEGYNALSWLAVDANTKDRLSCLPVHVQALMQLYHAAAALV
Length1974
PositionMiddle
OrganismHabropoda laboriosa
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Hymenoptera> Apocrita> Aculeata> Apoidea> Apidae> Habropoda.
Aromaticity0.07
Grand average of hydropathy-0.422
Instability index59.07
Isoelectric point5.75
Molecular weight215379.07
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP04713
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     152.12|      32|      32|     321|     352|       1
---------------------------------------------------------------------------
   67-   95 (31.05/12.65)	...............VW.....RRVSATPATSGPATA....SATGAGIFDLgI
   97-  141 (28.28/10.81)	PspappplsltaAKELWifwygEEPDLSGLVSPELIA....RESEQGSW....
  321-  352 (56.85/29.77)	P...........AKRVW.....AECTLSSPISASKTE....SSTEPGTWTF.I
  354-  384 (35.95/15.91)	P...........TQK.......SSCTCSNHVEKQDIKyigcRYTTPGGW....
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     191.40|      28|      32|     472|     499|       2
---------------------------------------------------------------------------
  406-  428 (31.77/ 8.17)	PF...HRRSTTQWDACPSVPANAPRS..
  431-  451 (33.25/ 8.91)	....NRTEAPSTPPGGP..PSYS.RGPP
  472-  499 (58.14/21.35)	PLPTPHSEPASVPPAEPTMPTLSPQPPP
  811-  835 (38.58/11.57)	.LPSQSLPPITLPSHCVYRP..SWQCSP
  863-  878 (29.66/ 7.11)	PLGAPYR............STISGRPPP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     107.16|      29|     501|     747|     787|       3
---------------------------------------------------------------------------
  724-  752 (54.58/36.67)	RP.EELSKMFPTPPSLEHNPVASPCQLNDP
  764-  793 (52.58/22.11)	RPlRHLPDIYPNMGSPQEEPIDDWSYVFKP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     100.83|      30|     366|     506|     537|       4
---------------------------------------------------------------------------
  506-  536 (54.04/24.66)	PPL.TPSQGPKSTSSACN...NQVHSPAAGPTlKR
  879-  912 (46.79/16.89)	PPYdQPSPATSTTSSYLNknlNSIEADTPGPT.RA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     227.98|      82|     366|     201|     313|       5
---------------------------------------------------------------------------
  201-  312 (123.41/126.91)	FVHGESTVCASVDVRQHPAVRHLTRACLQRTQTSqsgvKVILAPYGLAGTLT....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................gpvgrtdsqLLEEWKHFYPIngsnieaglpplvevlVGGVRMRYPS...CyVLVTDMDDTPPD
 1122- 1169 (70.16/30.00)	FLRAKGPQCSGDIVRMMRALQPLLQDAVQKKCTT....RMWEAPYTVAGPLT...................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................
 1663- 1699 (34.41/ 7.72)	....................................................wrqfhrlagrgtddrcepqpipalvvgydrdwlslspyalsyweklllepyagprdvayvivapdsdcvinkvksffrelsttyeicrlgrhtpiskalrdgilrvgkssvqkqakqpiddwfkllgenqlgellrlyaqvcnhrlapyltqviqdrslldpgdsqptnkqqqqttipvtdtmpatpdvmtnkpesvegenprsdtpssntatnsnsntgnttptsqtatihtnttsgpdeeeveppavvvylvepfslggpedpdrrrlailallraysaavnsmpenirsninvqiislesimelgrarerrkiqdemralalnvflqgrrllnhnstvksltgfgtaaaadlflkskdsysntlatihqernkapyrlyapayvlaplrakseapesfgiagpeecavlylsyclsedqswllavatddrgeifetatinidipnrkrrkrasarriglqklmdfilgvmsqgvsynekyqmnwllsrkaLLKASKHLKEI................CGQCSLLYPSaapC.VLSACLVSLEPD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     125.52|      39|     791|     551|     641|       6
---------------------------------------------------------------------------
  551-  589 (73.82/34.76)	NEQSLPWLY.....DYSTQEAWLNH.PVKRFKESN.SSPVNVRSNT
  665-  710 (51.69/63.41)	SYKDLDQIFdnsdpDTSSDETNLNQlQVQTPPESNrSSGLHEETRT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     379.30|     123|     142|    1303|    1433|       7
---------------------------------------------------------------------------
 1303- 1433 (195.85/126.46)	LLRLYAQVCN...HRLAPYL.TQVIQDRSLLDPGDSQPTNKQQQQTTIPVTDTMpATPDVMTNKPESVEGENPRSDTPSSNTATNSNSNTGNTtptsqTATIHTNTTSGPdeEEVEPPAVVVYLV.......EPFSLGGPED
 1444- 1577 (183.45/100.76)	LLRAYSAAVNsmpENIRSNInVQIISLESIMELGRARERRKIQDEMRALALNVF.LQGRRLLNHNSTVKSLTGFGTAAAADLFLKSKDSYSNT.....LATIHQERNKAP..YRLYAPAYVLAPLrakseapESFGIAGPEE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      40.09|      10|     367|     458|     467|       8
---------------------------------------------------------------------------
  458-  467 (20.42/ 9.78)	PVPSVGSPGS
 1792- 1801 (19.67/ 9.06)	PEPGAGGGQS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     144.40|      40|    1033|     144|     183|      11
---------------------------------------------------------------------------
  144-  183 (73.34/38.15)	GLSYECRSLLFKALHNLIERCLLSRDFVRLGKW...FVQPYDG
 1180- 1222 (71.07/36.76)	GTDDRCEPQPIPALVVGYDRDWLSLSPYALSYWeklLLEPYAG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      65.46|      19|      35|     945|     963|      17
---------------------------------------------------------------------------
  945-  963 (35.07/19.34)	CNAGPKVVGNIKGA.DAGVY
  982- 1001 (30.39/15.83)	CSCGFSAVVNRRLAhKAGLF
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP04713 with Med13 domain of Kingdom Metazoa
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