<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP04712

Description Mediator of RNA polymerase II transcription subunit 23
SequenceMLRTRACSTAARRRLGRVYKYEEENNRLSKYQKKLHSIMSTLGPEMQESAMRQYLTLTAVLTNRYKMRQLLTLLENLINTNILQARMLCDCILTNEKLIYQNADFWIECFNLIRRVIGGVDYKGVREIMKQLAKLLTSFVESFKPCAQMVSIIGHSQMLPVVEFSGYADHLINPWRLDPTTLKFSLKGNLPYDDDLLKPQISLLRHVLQQPYSRDMMCSMLGLQKQHKQRCIALEDQLVELMILPMERSEQETEEDEMSSTHWCWLHLSSQVIYLILIGFASFPNIVMGLHNKLIGHDMKKGRDHLMWVLLQFISGSIQRNPLSNFLPIIKLHELLYPEKEPLPVPDCTKAHCTHQMAVVCIWMHLLKKAEFLQHLVTSNNTPALMGSDYRIALLCNAYSTNQEFYARPMGIIIETLFGSQKALPNGNPGTPLPTVPLSMCILDSLTLHCKMSLIHSIVTHVAKLAQNKTNIPGSSMMAPALVETYSRLLVYTEIESLGIKGFINQLLPNVFKSHAWGILHNLLDMFSYRIHHIQPHYRVTLLSNIHSLAAYPQANQTQLQLCFESTALRLITSLGSSGVQLQMSRVVSEPKSLVSSESEELNPVKELLTTIITNTPHMWSQHTLQCFPPVLVEFFSQNTTTQENKQVLKKSVEEEYRKWTSMANDNDIISHFSVPGTPLILERIGARALSAHLRKFCDYLVLEVTNPAGGPHINKCVDAINDIIWKYNIVTIDKLVLCLLLLLKGSELRNRAQDFVKENSPEHWKQNNWLKYPEKFAPEEPNNAYGGPIPVYLSNVCLRFIPVLDIVVHRYLEIPQLRDKPLLKRKLLNAVLGSLKDVRPSGWATTEVFQAYLNKTETEATGWTPDLNYYLTLVNRMVDTMNGNSHFPNTDWRFNEYPNPSAHSLYVTCVELMALPMSPKYVGNSLLDVISKGFVVIPPMKIQLWINAIGLIMAALPDPYWTVIQERVSEVIADSDLTEWPHSHTPFQLFNLKTTSEVMLENKYSLTLALAHAIWYHASAGQIMQVPVYIKDKLSLEIHSETQLLFLCHLVGPFLQRFNSDLYHIKYMFVGDTMKNEVESVIRKLRPSLQMRLRFITHLNVEQINTA
Length1108
PositionTail
OrganismOperophtera brumata (winter moth)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Lepidoptera> Glossata> Ditrysia> Geometroidea> Geometridae> Larentiinae> Operophtera.
Aromaticity0.08
Grand average of hydropathy-0.081
Instability index43.81
Isoelectric point8.27
Molecular weight126898.46
Publications
PubMed=26227816

Function

Annotated function 
GO - Cellular Component
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP04712
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.75|      13|      18|      51|      68|       1
---------------------------------------------------------------------------
   51-   63 (23.68/17.25)	MRQYLTLTAVLTN
   67-   79 (23.07/ 8.70)	MRQLLTLLENLIN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.27|      16|      18|     681|     698|       2
---------------------------------------------------------------------------
  681-  698 (18.78/18.04)	ILErIGARALSAHLRKfC
  702-  717 (30.49/17.01)	VLE.VTNPAGGPHINK.C
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     372.99|     114|     652|     279|     396|       3
---------------------------------------------------------------------------
  279-  396 (187.99/133.98)	GFASFPNIVMGLHNKLIGHDMKKGRDHLmWVLLQ.FISGSIQRNPLSNFlPIIKLHELLYPEKEPLPVPDCTKAHCTHQMAVVcIWMHlLKKAEFLQHLVTSNNTPAL.MGSDYRIALLC
  934- 1049 (184.99/115.04)	GFVVIPPMKIQLWINAIGLIMAALPDPY.WTVIQeRVSEVIADSDLTEW.PHSHTPFQLFNLKTTSEVMLENKYSLTLALAHA.IWYH.ASAGQIMQVPVYIKDKLSLeIHSETQLLFLC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.42|      13|      18|     191|     203|       4
---------------------------------------------------------------------------
  191-  203 (23.54/12.26)	PYDDDLLKPQISL
  211-  223 (25.88/14.13)	PYSRDMMCSMLGL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.08|      13|      18|     793|     805|       5
---------------------------------------------------------------------------
  793-  805 (24.33/13.08)	YLSNVCLRFIPVL
  812-  824 (23.76/12.62)	YLEIPQLRDKPLL
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP04712 with Med23 domain of Kingdom Metazoa
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