<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP04711

Description Mediator of RNA polymerase II transcription subunit 1
SequenceMTEGSSVTMMSTPNGLLDKSKELQKEILMEKLRSKTSQYKNLAETSKGVRMTMLDKRWALDSQDRMILQKCLDSLQHCIKVGSLQSLIERLECLSRQLGLKFVVGTSGVNLFISSDMFYLEIIIEQQSCEELVQCISQGDFADFTSQLEGLTAVYQLNAEKKVKCKAFSALQSLEEDLCTMRQIQSFIKDPWAQGLLPLTVDLLTLGKPQASSGLASLVAPSHTQIGHSATVLLEGSAANKLHAMLPACFTLKLSQPTPLCAGLAKLIHATTEVEVAADWSNAKPLLGLVAQQAYNKLTPGKVIELNLSKGLFVNLPDQMQCYFVCETRGLNACCVTSVPFTHPSQVPPLLACLRQQALFNTLLASCVRTQAKQGALHIATYITQHTTYSLSALSWQHISISLEHPLDESMATVELELSDPSTPRASVYSLNTPAREQIDEYISRVLQKSHSIPITLRSLVKIWEREASTKQMNGGYSALDANFSCGLGGIDPGGDHHHLSLMCQDDIKTEPSERKTKKRKSDSDLWPGQKKGKPGGIAEMMDSDSDSDSFVNDDDNTNNSNSTNDDGRESLASQNEFVSDLELSGMDATDARSQDNRTSSDMDNSNDADLEDNMMSKDAEIRSRSASSLLLDLTEGKPYMPSSVSITPIGSNSGASQSGASISSMLCLDRRPGIEIIPITAAAPAALPSSITITPITTSQMKSMDDRMRPDKKSSKSGEERSKEKKKKRRRDDPMGPPEKVPPKQDPLTKPVSVSIKPTDGSPLRSTSPNSLLRKFSPSPTHGRSVSITKSLSPSTVKGLGKPSGTSSHHSSPRHSPVPNSPKHLPGYSSPKNPSVSSPKHSSSGSGKPSMSALKSATSGSPSGKSGTTGYDLSKKISNSSSSVTSSREKEKKHSGLNFSSSGRSSPKLKNPVKLKQLEITPITCDSPVTEPLISPPNVEMNKTNAPSAARNRKGSLSAVIDKLKSAQHCGTEIDMSSKSSSSSSSSKNYSDPKNASSKSSESKNQEYMVKPSSDGMKITINKTRTKESSSSSSSSKLNYSNSSSGKQSSPQLTPPSQGSPKTHTGLKPGVISGPASKKTQAMQSSKSGNVTPGSTPPKANLSPSDSSSNNTNMTKVPYKSSSTSSSTGINLTKSASKSSSGSPKSGSGDLSKVMRDREREKARTKLMTNSEKSIFSKSERHSSPSSRDEVDGYKPKDASNFLVEGLIKPLDTSKFQIPKLKNQNTTDKNSPSSQYDSRSMVNDFSRTMDQQKYPFSHFDHRTADPLQKSAYPLNVPKPLMNMGGMSPKLPPGKEPDRPLEFAKIADSISKGETPQRTKDEAKDYSGTFPLMPLDFKTEASKGFAAPKGSEDRKGADSCMKPPASGAVARSGATTPQEAAEMLLDFSSSSGSKVSGLVAVRPVYPNSPALALQLAKSPAPSPLVAPSPHSNSPGITDDELMDEALVGPGK
Length1451
PositionMiddle
OrganismOperophtera brumata (winter moth)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Lepidoptera> Glossata> Ditrysia> Geometroidea> Geometridae> Larentiinae> Operophtera.
Aromaticity0.04
Grand average of hydropathy-0.618
Instability index55.87
Isoelectric point9.12
Molecular weight155734.73
Publications
PubMed=26227816

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP04711
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     206.20|      39|      41|    1024|    1062|       1
---------------------------------------------------------------------------
  792-  829 (37.48/ 9.13)	.SLSPSTVKGLGKPS....GTSSHHSSPR...HSPvPN..SP...........kHLPGY
  830-  876 (39.24/ 9.93)	SSPKNPSVSSPKHSS....SGSGKPSMSA...LKS.ATSGSP....sgksgttgYDLSK
  980- 1028 (35.71/ 8.33)	KSSSSSSSSK.NYSDpknaSSKSSESKNQeymVKP.SSDGMK........itinKTRTK
 1029- 1069 (60.46/19.52)	ESSSSSSSSKLNYSN....SSSGKQSSPQ...LTP.PSQGSP..........ktHTGLK
 1122- 1167 (33.31/ 7.25)	.SSSTSSSTGINLTK....SAS.KSSSGS.......PKSGSGdlskvmrdrereKARTK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     210.06|      56|      58|    1211|    1266|       2
---------------------------------------------------------------------------
 1179- 1221 (59.34/27.32)	........KSERHSSPSSRDEVDGY..............KPKDASN.....F....LVEGLIKPLD.TSK.F..QIPK
 1222- 1279 (92.62/47.25)	LKNQNTTDKNSPSSQYDSRSMVNDFS.............RTMDQQK.....YPFSHFDHRTADPLQ.KSA.YplNVPK
 1281- 1349 (58.09/26.58)	LMNMGGMSPKLPPGKEPDRPL..EFAkiadsiskgetpqRTKDEAKdysgtFPLMPLDFKT.....eASKgF..AAPK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     166.01|      51|      60|      38|      97|       3
---------------------------------------------------------------------------
   40-   94 (78.58/80.03)	KNLAETSkGVRMTMLDKRWALDSqdrMILQKCLDSLQHCIKVGSLQSLIERLECL
  101-  151 (87.43/56.71)	KFVVGTS.GVNLFISSDMFYLEI...IIEQQSCEELVQCISQGDFADFTSQLEGL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     175.28|      48|      60|     657|     704|       4
---------------------------------------------------------------------------
  599-  650 (53.68/27.98)	TS....SDMDN...........SNDadlednmmskdaeirSRS....ASSLL.LD..............LTEGKP.YMPSSVSITPI
  651-  697 (57.59/30.66)	GSnsgaSQ...................................sgasISSMLCLDRR.....PGIEIIPITAAAPAALPSSITITPI
  698-  760 (64.00/35.07)	TT....SQMKSmddrmrpdkksSKS...............GEE....RSKEKKKKRRrddpmGPPEKVP.PKQDPLTKPVSVSIKPT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     112.69|      25|      58|    1362|    1386|       5
---------------------------------------------------------------------------
 1362- 1386 (41.91/21.51)	KPPA.SGAVARS.GATTPQEAAEMLLD
 1392- 1414 (36.18/17.50)	GSKV.SGLVAVR..PVYPNSPA.LALQ
 1417- 1443 (34.59/16.39)	KSPApSPLVAPSpHSNSPGITDDELMD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     128.71|      40|     166|     903|     946|       6
---------------------------------------------------------------------------
  903-  946 (62.04/51.86)	SGRSSPKLKNPVKLKQLEITPitcDS.PVTEPLiSPPNVEMNKTN
 1074- 1114 (66.67/41.71)	SGPASKKTQAMQSSKSGNVTP...GStPPKANL.SPSDSSSNNTN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.87|      18|      67|     281|     298|       7
---------------------------------------------------------------------------
  281-  298 (31.60/19.55)	SNAKPLLGLVAQQA.YNKL
  345-  363 (29.27/17.57)	SQVPPLLACLRQQAlFNTL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     101.28|      31|     434|     512|     544|      10
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  467-  506 (45.41/23.10)	EASTKQMNGgysalDANFSCGLGGIDPGGdhhhLSLMCQD
  514-  544 (55.87/28.34)	ERKTKKRKS.....DSDLWPGQKKGKPGG....IAEMMDS
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP04711 with Med1 domain of Kingdom Metazoa
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