Description | Mediator of RNA polymerase II transcription subunit 1 |
Sequence | MTEGSSVTMMSTPNGLLDKSKELQKEILMEKLRSKTSQYKNLAETSKGVRMTMLDKRWALDSQDRMILQKCLDSLQHCIKVGSLQSLIERLECLSRQLGLKFVVGTSGVNLFISSDMFYLEIIIEQQSCEELVQCISQGDFADFTSQLEGLTAVYQLNAEKKVKCKAFSALQSLEEDLCTMRQIQSFIKDPWAQGLLPLTVDLLTLGKPQASSGLASLVAPSHTQIGHSATVLLEGSAANKLHAMLPACFTLKLSQPTPLCAGLAKLIHATTEVEVAADWSNAKPLLGLVAQQAYNKLTPGKVIELNLSKGLFVNLPDQMQCYFVCETRGLNACCVTSVPFTHPSQVPPLLACLRQQALFNTLLASCVRTQAKQGALHIATYITQHTTYSLSALSWQHISISLEHPLDESMATVELELSDPSTPRASVYSLNTPAREQIDEYISRVLQKSHSIPITLRSLVKIWEREASTKQMNGGYSALDANFSCGLGGIDPGGDHHHLSLMCQDDIKTEPSERKTKKRKSDSDLWPGQKKGKPGGIAEMMDSDSDSDSFVNDDDNTNNSNSTNDDGRESLASQNEFVSDLELSGMDATDARSQDNRTSSDMDNSNDADLEDNMMSKDAEIRSRSASSLLLDLTEGKPYMPSSVSITPIGSNSGASQSGASISSMLCLDRRPGIEIIPITAAAPAALPSSITITPITTSQMKSMDDRMRPDKKSSKSGEERSKEKKKKRRRDDPMGPPEKVPPKQDPLTKPVSVSIKPTDGSPLRSTSPNSLLRKFSPSPTHGRSVSITKSLSPSTVKGLGKPSGTSSHHSSPRHSPVPNSPKHLPGYSSPKNPSVSSPKHSSSGSGKPSMSALKSATSGSPSGKSGTTGYDLSKKISNSSSSVTSSREKEKKHSGLNFSSSGRSSPKLKNPVKLKQLEITPITCDSPVTEPLISPPNVEMNKTNAPSAARNRKGSLSAVIDKLKSAQHCGTEIDMSSKSSSSSSSSKNYSDPKNASSKSSESKNQEYMVKPSSDGMKITINKTRTKESSSSSSSSKLNYSNSSSGKQSSPQLTPPSQGSPKTHTGLKPGVISGPASKKTQAMQSSKSGNVTPGSTPPKANLSPSDSSSNNTNMTKVPYKSSSTSSSTGINLTKSASKSSSGSPKSGSGDLSKVMRDREREKARTKLMTNSEKSIFSKSERHSSPSSRDEVDGYKPKDASNFLVEGLIKPLDTSKFQIPKLKNQNTTDKNSPSSQYDSRSMVNDFSRTMDQQKYPFSHFDHRTADPLQKSAYPLNVPKPLMNMGGMSPKLPPGKEPDRPLEFAKIADSISKGETPQRTKDEAKDYSGTFPLMPLDFKTEASKGFAAPKGSEDRKGADSCMKPPASGAVARSGATTPQEAAEMLLDFSSSSGSKVSGLVAVRPVYPNSPALALQLAKSPAPSPLVAPSPHSNSPGITDDELMDEALVGPGK |
Length | 1451 |
Position | Middle |
Organism | Operophtera brumata (winter moth) |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Lepidoptera> Glossata> Ditrysia> Geometroidea> Geometridae> Larentiinae> Operophtera. |
Aromaticity | 0.04 |
Grand average of hydropathy | -0.618 |
Instability index | 55.87 |
Isoelectric point | 9.12 |
Molecular weight | 155734.73 |
Publications | PubMed=26227816 |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364059 |
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro |
Binary Interactions |
Repeats | >MDP04711 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 5| 206.20| 39| 41| 1024| 1062| 1 --------------------------------------------------------------------------- 792- 829 (37.48/ 9.13) .SLSPSTVKGLGKPS....GTSSHHSSPR...HSPvPN..SP...........kHLPGY 830- 876 (39.24/ 9.93) SSPKNPSVSSPKHSS....SGSGKPSMSA...LKS.ATSGSP....sgksgttgYDLSK 980- 1028 (35.71/ 8.33) KSSSSSSSSK.NYSDpknaSSKSSESKNQeymVKP.SSDGMK........itinKTRTK 1029- 1069 (60.46/19.52) ESSSSSSSSKLNYSN....SSSGKQSSPQ...LTP.PSQGSP..........ktHTGLK 1122- 1167 (33.31/ 7.25) .SSSTSSSTGINLTK....SAS.KSSSGS.......PKSGSGdlskvmrdrereKARTK --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 3| 210.06| 56| 58| 1211| 1266| 2 --------------------------------------------------------------------------- 1179- 1221 (59.34/27.32) ........KSERHSSPSSRDEVDGY..............KPKDASN.....F....LVEGLIKPLD.TSK.F..QIPK 1222- 1279 (92.62/47.25) LKNQNTTDKNSPSSQYDSRSMVNDFS.............RTMDQQK.....YPFSHFDHRTADPLQ.KSA.YplNVPK 1281- 1349 (58.09/26.58) LMNMGGMSPKLPPGKEPDRPL..EFAkiadsiskgetpqRTKDEAKdysgtFPLMPLDFKT.....eASKgF..AAPK --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 166.01| 51| 60| 38| 97| 3 --------------------------------------------------------------------------- 40- 94 (78.58/80.03) KNLAETSkGVRMTMLDKRWALDSqdrMILQKCLDSLQHCIKVGSLQSLIERLECL 101- 151 (87.43/56.71) KFVVGTS.GVNLFISSDMFYLEI...IIEQQSCEELVQCISQGDFADFTSQLEGL --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 3| 175.28| 48| 60| 657| 704| 4 --------------------------------------------------------------------------- 599- 650 (53.68/27.98) TS....SDMDN...........SNDadlednmmskdaeirSRS....ASSLL.LD..............LTEGKP.YMPSSVSITPI 651- 697 (57.59/30.66) GSnsgaSQ...................................sgasISSMLCLDRR.....PGIEIIPITAAAPAALPSSITITPI 698- 760 (64.00/35.07) TT....SQMKSmddrmrpdkksSKS...............GEE....RSKEKKKKRRrddpmGPPEKVP.PKQDPLTKPVSVSIKPT --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 3| 112.69| 25| 58| 1362| 1386| 5 --------------------------------------------------------------------------- 1362- 1386 (41.91/21.51) KPPA.SGAVARS.GATTPQEAAEMLLD 1392- 1414 (36.18/17.50) GSKV.SGLVAVR..PVYPNSPA.LALQ 1417- 1443 (34.59/16.39) KSPApSPLVAPSpHSNSPGITDDELMD --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 128.71| 40| 166| 903| 946| 6 --------------------------------------------------------------------------- 903- 946 (62.04/51.86) SGRSSPKLKNPVKLKQLEITPitcDS.PVTEPLiSPPNVEMNKTN 1074- 1114 (66.67/41.71) SGPASKKTQAMQSSKSGNVTP...GStPPKANL.SPSDSSSNNTN --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 60.87| 18| 67| 281| 298| 7 --------------------------------------------------------------------------- 281- 298 (31.60/19.55) SNAKPLLGLVAQQA.YNKL 345- 363 (29.27/17.57) SQVPPLLACLRQQAlFNTL --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 101.28| 31| 434| 512| 544| 10 --------------------------------------------------------------------------- 467- 506 (45.41/23.10) EASTKQMNGgysalDANFSCGLGGIDPGGdhhhLSLMCQD 514- 544 (55.87/28.34) ERKTKKRKS.....DSDLWPGQKKGKPGG....IAEMMDS --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) ITDDELMDEALVG 2) KNPVKLKQLEIT 3) RPLEFAKIADSI 4) VAVRPVYPNSPALALQLA | 1436 911 1299 1399 | 1448 922 1310 1416 |
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Designed by Dr. Shailesh Lab & Dr. Jitendra K. Thakur Lab