<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP04709

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMERLRPSHGAHARRVAPALPARTGLRRRRVILAPFGLEGTLTGREWSDSDPPTARMLDAWRQLYPLEQGCGAVEVTICSDPGSVRAGRHADGSRMERLRPSHGAHARRVAPAVPARTGLRRRRVILAPFGLEGTLTGREWSDSDPPTARMLDAWRQLYPLEQGCGAVEVTICSDPGSVRAGRHADGSRMERLRPSHGAHARRVAPALPARTGLRRRRVILAPFGLEGTLTGREWSDSDPPITARMLDAWRQLYPLEQGCGAVEVVCGSARMRYPLPYVLVTEMEAAGAPPATPAAIAHKALQALTTPAPHQTAELSYADAAGDKSEDFVDPTRKTPCTCAKAPIMVKSEPYILGHVAQIGIDRRLTHLTGLSCRLLRSVTDPNESIVLRLEHPVKRFKPTEAYFREELVLGGCEGDLCLIIPEPLLTCHTYKKHPSKISNQTDLFQDDSKEYKNLFTSDGLCATFKDLDQIFDNSDDAASGDETLQVQTPPDSNKSGDEARCRVRAEELSKMFPTPPSMEAHAQPSPGFTLGDETRLHLAQPAPALHLPHRDAGSPAPDQPIEDWSYVFKPPTVCKYVGSSKYAPLATLPSQLLPAVTLPPHAVYRPRARDPQRAHTPAAPHTPAPPGTPGPAPSSVVGNIRGADAATYLNEVCAGWGEGGDEEPPRCTCGFSAVVNRRRAHRAGLFYEDEMEITGLAEEPGLRCGGGGGLTDVAGLVVEQCAGSAGGDASALARAARRAADHAPHDELSLNVLEYTDGGSAAARALREAGGSGAASACSAVSMTGGVHRWPFIGARAPRSSRDVVRLMRRLRPLLQDAIQKRCCGARMWDGVTGPLTWRQFHRLAGRGNEDLCEPQPVPPLLVGHDRDWLALAPYALRHWERLQLEPYSYPRDVAYAVLAPDSEALQDPLRAFFRELSAAYEACRLGRHRPLLRVGRDGILRASPSAANSGDDEWTGPLPSGRASAYIRGSLVPQLAGITVDRTLIDGERPDTVRPPTAPEPGTPHDENEGGITAPYNSPAWHEEDESGTPALVIYVDGVPVGSGGAGAGAAAGARALAFSVFTGARRLLQHRADGKSLTGFGTAAAANLKRTARHTSCSPPRGCCPRPACWAAARARLPTAGGSRAASKAPSRRRRSGPARRLGLTKLMDFTLGVMSQAAQPWRLVVGRVGRIGHGELKVLPQAAVPCILSACLVSTEPEPALRLMADRFTPDERFSQHSLHSALHTPRDTPMANGEDNDMMFLNVDMGDEDMGDDQMTDIFSTDMFNSMFAQTSPTRRGDEDGAGEEAAAHAHANAHKQRGDNDQHEAVGTVLQQPLALGYLVSTAPLGGMPAWWWAGCGHLRDACPAFLRSALHLQQADDITSLLQRRDHNAHPLDSQLTTDVLRYVLEGYNALSWLALDGNTADRVSCLPLHVQVLMQLYHTAAALG
Length1432
PositionMiddle
OrganismOperophtera brumata (winter moth)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Lepidoptera> Glossata> Ditrysia> Geometroidea> Geometridae> Larentiinae> Operophtera.
Aromaticity0.06
Grand average of hydropathy-0.386
Instability index53.04
Isoelectric point7.16
Molecular weight154455.85
Publications
PubMed=26227816

Function

Annotated function Component of the Mediator complex, a coactivator involved in regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP04709
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
            11|    1088.06|      92|      92|      20|     111|       1
---------------------------------------------------------------------------
    1-   94 (190.84/75.15)	MERLRPS..HGAHARRVAP.alPARTGLRRRRVI..LAP..FGLEG.....TLT..G..............RE............WSDS.DPP..TAR.................MLD......AWR............QL..YPL....EQG...C..G...................AVEVT..ICSDP..G.SV.RA...G.....RHA.DG........SR
   95-  188 (190.84/75.15)	MERLRPS..HGAHARRVAP.avPARTGLRRRRVI..LAP..FGLEG.....TLT..G..............RE............WSDS.DPP..TAR.................MLD......AWR............QL..YPL....EQG...C..G...................AVEVT..ICSDP..G.SV.RA...G.....RHA.DG........SR
  189-  270 (151.28/58.00)	MERLRPS..HGAHARRVAP.alPARTGLRRRRVI..LAP..FGLEG.....TLT..G..............RE............WSDS.DPP.iTAR.................MLD......AWR............QL..YPL....EQG...C..G...................AVEV...VC.....G.SA.R..........................
  512-  605 (81.81/27.87)	MFPTPPS..MEAHAQ...P..sPGFTLGDETRLH..LAQ..PAPAL.....HLP..H..............RDagspapdqpiedWSYVfKPP..TVC.................KYV......GSS............KY..APLatlpSQL...L..P...................AVTL......PP...................HA...........VY
  606-  718 (61.11/18.89)	RPRARDP..QRAHT.PAAP.htPAPPGTPGP......AP..SSVVG.....NIR..GadaatylnevcagwGE............GGDE.EPPrcT............................................................C..GfsavvnrrrahraglfyedEMEIT.gLAEEP..G..L.RC...GgggglTDV.AG........LV
  719-  807 (84.04/28.84)	VEQCAGS..AGGDASAL......ARAA..RRAAD..HAP..HD.EL.....SLN..V..............LE............YTDG.GSA..AAR.................AL.........R............EAggSGA....ASA...C..S...................AVSMTggVHRWPfiG.A..RA...P.....RSSrDV........VR
  809-  880 (69.73/22.63)	MRRLRP...........................L..L.......QD.....AIQ..K..............RC............CG.........AR.................MWDgvtgplTWR............QF..HRL.....AG...R..G...................N.E.D..LC.EP..Q.PV.PPllvG.....HDR.DWlalapyalRH
  881-  940 (61.43/19.03)	WERLQLE..PYSYPRDVAY.............AV..LAPdsEALQD.....PLR..A............ffRE............LSAA...Y..EAC.................RLG......RHR............PL....L....................................................RV...G.....R...DG..........
  941- 1042 (70.24/22.85)	ILRASPSaaNSGDDEWTGP..lPSGRASAYIRGS..LVP...QLAGitvdrTLI..D..............GE............RPDTvRPP..TAPepgtphdeneggitapyNSP......AWH............E....ED....ESG...T..P...................ALVI...........................YV.DG........VP
 1043- 1116 (60.32/18.55)	VGSGGAG..AGAAAGARA.lafSVFTGARR......LLQ..HRADG....kSLTgfG..............TA............AAAN.LKR..TAR.................H...................................................................T..SCSPP.rG.CCpRP...A.....CWA...........AA
 1117- 1217 (66.42/21.20)	RARLPTA..GGSRAASKAP.srRRRSGPARRLGLtkLMD..FTL.G.....VM...........................................SQ.................AAQ......PWRlvvgrvgrighgEL..KVL....PQAavpCilS...................ACLVS..TEPEP..AlRL.MA...D.....RFT.PD........ER
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     166.27|      52|     772|     455|     506|       3
---------------------------------------------------------------------------
  455-  506 (93.72/56.61)	LFT.SDGLCATFKDLDQIFDNSD..DAASGDETLQ............VQTPP....DSNKSGDEARCRVRA
 1227- 1297 (72.56/42.07)	LHTpRDTPMANGEDNDMMFLNVDmgDEDMGDDQMTdifstdmfnsmfAQTSPtrrgDEDGAGEEAAAHAHA
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP04709 with Med13 domain of Kingdom Metazoa
Unable to open file!