Description | Mediator of RNA polymerase II transcription subunit 4 (Fragment) |
Sequence | QILATSLYQARQKLASIEKSRKKPVPSEELIKFAHRISASNAVSAPLSWQPGDPRRPYPTDLEMRVGMLGRLCDLPLNGHTPSTLNELHRMTTGGAVPASAPNQFTWHPTGELHMSVGGGGSVALDARGKDASAQEDVEVMSTDSSSSSSSDSQ |
Length | 154 |
Position | Middle |
Organism | Operophtera brumata (winter moth) |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Lepidoptera> Glossata> Ditrysia> Geometroidea> Geometridae> Larentiinae> Operophtera. |
Aromaticity | 0.04 |
Grand average of hydropathy | -0.514 |
Instability index | 52.38 |
Isoelectric point | 6.57 |
Molecular weight | 16438.19 |
Publications | PubMed=26227816 |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364141 |
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro |
Binary Interactions |
Repeats | >MDP04703 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 3| 95.16| 20| 23| 76| 95| 1 --------------------------------------------------------------------------- 76- 95 (37.71/23.04) PLNGHTPSTLNELHRMTTGG 102- 119 (36.11/21.82) P.NQFTWHPTGELH.MSVGG 126- 143 (21.34/10.53) DARGKDASAQEDVEVMST.. --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) DARGKDASAQEDVEVMST 2) ILATSL 3) SEELIKFAHRISA 4) YPTDLEMRV | 126 2 27 58 | 143 7 39 66 |
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