Description | Mediator of RNA polymerase II transcription subunit 15 (Fragment) |
Sequence | MSGTEDNWRTQAFRQSVVSKIEEVIQRSGMQVARNSSEMENHVFMKAKTREDYMNMVAKLILHVREMCKIIIRNLNNISAQPKQNNQVAAQNMQGPNQGQGGLPPQGQNQQGQPPQGPNSQSNLAPDPINALQTLASQGS |
Length | 140 |
Position | Tail |
Organism | Operophtera brumata (winter moth) |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Lepidoptera> Glossata> Ditrysia> Geometroidea> Geometridae> Larentiinae> Operophtera. |
Aromaticity | 0.03 |
Grand average of hydropathy | -0.811 |
Instability index | 57.64 |
Isoelectric point | 9.36 |
Molecular weight | 15482.26 |
Publications | PubMed=26227816 |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364148 |
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro |
Binary Interactions |
Repeats | >MDP04693 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 65.86| 18| 20| 86| 105| 1 --------------------------------------------------------------------------- 86- 105 (28.62/18.71) NQvAAQNMQGPNqGQGGLPP 109- 126 (37.24/16.57) NQ.QGQPPQGPN.SQSNLAP --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) APDPINALQTLASQ 2) IRNLNNIS | 125 72 | 138 79 |
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