Description | Mediator of RNA polymerase II transcription subunit 11 |
Sequence | MAAPMERIQVLDDIEKDIITCLQCSAQALLELSKEKSGQKQAEANTTQFLRTLNQVESKLSDQINYLTQVSTGQPHEGSGYASQKVLQMAWHRLEHVRSWVNELDRLKASHLAATTRTQPGNVPNGNMTSSGTST |
Length | 135 |
Position | Head |
Organism | Operophtera brumata (winter moth) |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Lepidoptera> Glossata> Ditrysia> Geometroidea> Geometridae> Larentiinae> Operophtera. |
Aromaticity | 0.04 |
Grand average of hydropathy | -0.579 |
Instability index | 26.87 |
Isoelectric point | 6.41 |
Molecular weight | 14938.60 |
Publications | PubMed=26227816 |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364147 |
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro |
Binary Interactions |
Repeats | >MDP04690 No repeats found No repeats found |
MoRF Sequence | Start | Stop |
1) KLSDQINYLTQV 2) TQFLRTLNQ | 59 47 | 70 55 |
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