<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP04688

Description Mediator of RNA polymerase II transcription subunit 26
SequenceMHTVNEIISILEKFNITKELLETSDPQLARRAKVLVKRWRDLVIPSVASPGHTAVKRPPSPQPLYDEKRAKRDKKPKKRSKPPASPGSPDVMLIEDTPPLPPLEDEREYHECTCGEVAELDCPAARSLEVHPLHIRALHHAYLPGINGTRAPIYPHQFAVRKLTDPERPDLFTSVVPLYNYSDYADDHCTKNMSKVPLCSHLPWTEFAPSPPEPPPPPSPPPIRPYPIDDVVKEETLQTKEDNSLDSEATNCSLDDINIEAEMVSVPNLEPSERLKAPILSIDEETQFCKVESGVPEKMEVEEEFETEHQDHRTVERTKEDLNGQALYDMVQCTIDNIPYDYNQMSLAPVITLPEEVVEASPALEEALTRSEAETERLTFDRPPRPDNFTEWHECARLGELIALPYVVID
Length410
PositionUnknown
OrganismOperophtera brumata (winter moth)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Lepidoptera> Glossata> Ditrysia> Geometroidea> Geometridae> Larentiinae> Operophtera.
Aromaticity0.06
Grand average of hydropathy-0.637
Instability index75.42
Isoelectric point4.81
Molecular weight46426.87
Publications
PubMed=26227816

Function

Annotated function 
GO - Cellular Component
nucleus	GO:0005634	IEA:InterPro

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP04688
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     174.32|      55|     123|      86|     153|       1
---------------------------------------------------------------------------
   86-  149 (89.62/43.63)	PGSPDvmliedTPPLP........PLEDEREYHECTCGEVAELDCPAAR.SLEvhPLHIRAlHHAYLPGINGT
  209-  272 (84.70/28.37)	PSPPE......PPPPPspppirpyPIDDVVKEETLQTKEDNSLDSEATNcSLD..DINIEA.EMVSVPNLEPS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.78|      12|     214|     162|     173|       2
---------------------------------------------------------------------------
  162-  173 (25.02/12.54)	KLT.D.PERPDLFT
  377-  390 (17.76/ 6.71)	RLTfDrPPRPDNFT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      59.75|      18|     113|      63|      83|       3
---------------------------------------------------------------------------
   25-   45 (27.66/11.82)	DPQLARRAKVLVKRWRDlviP
   66-   83 (32.09/14.52)	DEKRAKRDKKPKKRSKP...P
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP04688 with Med26 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) ASPGHTAVKRPPSPQPLYDEKRAKRDKKPKKRSKPPASPGSPDVMLIEDTPPL
2) TQFCKVESGVPEKMEVEEEFETEHQDHRTVERTKED
3) WTEFAPSPPEPPPPPSPPPIRPYPIDDVVKEETLQTKEDNSLDSEATNCSL
48
286
204
100
321
254










Molecular Recognition Features






MoRF SequenceStartStop




1) PQPLYDEKRAKRDKKPKKRSKP
2) VLVKRWRDLVIPSVASPGHTAVK
61
34
82
56