Description | Mediator of RNA polymerase II transcription subunit 9 |
Sequence | MENNTDHSEQNNYPLSVQEVDVDFLPIVYEIIRSVERDYHETSAKARESQECSVKVLELQKKLEIARTQIKRLPGIEFNKKDQIKQFEILRTQLRLKRELLQKYRNMCSFETSFK |
Length | 115 |
Position | Middle |
Organism | Operophtera brumata (winter moth) |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Lepidoptera> Glossata> Ditrysia> Geometroidea> Geometridae> Larentiinae> Operophtera. |
Aromaticity | 0.08 |
Grand average of hydropathy | -0.815 |
Instability index | 48.01 |
Isoelectric point | 7.75 |
Molecular weight | 13793.59 |
Publications | PubMed=26227816 |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364145 |
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro |
Binary Interactions |
Repeats | >MDP04686 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 38.36| 12| 21| 61| 80| 1 --------------------------------------------------------------------------- 61- 73 (16.56/26.92) KKLEIARTQIkRL 85- 96 (21.80/ 7.55) KQFEILRTQL.RL --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) FEILRTQLRLKRE 2) NNYPLSVQEVDVDFLPIVYEIIRSVERDYHETSAKAR 3) QECSVKVLELQKKLEIARTQIKRLPGIEFN | 87 11 50 | 99 47 79 |
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