<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP04676

Description Mediator of RNA polymerase II transcription subunit
SequenceMDASKITSKTSSLKALILKAWRERWTDIQWGINIKTILPRGVSGDLYNLADCILQQAMVGCGANQLVISYLKHSLASHLVSYAAVLQRIAKFDAFHKPHCVSSLLEFLESFLDSITCRGKLEEETLTYAVSSIILWLLQVYHYCLSKPSTNPIQSQEILEKSTTLLNQIVSSDFLLAMFYLARQNDPEEFQEVTKKCKEIQAFMMMNTQFKAPVTIHETIQKICVVDIDKVAPLNNKAEPVTHCLQALITVNVLANPSADMQQLSSQLLMVHRIKSYSLSRLYCELIRSCFISLNDSSKDTSKQALWAAFTFLKIPQVMHYIHNTCGTTNKESEYSVEIVEAFEKLLQATPLLDVVDTKNSCNSIVSLLEPLVKLNVVSESHLLYIQKKRESNNTKLQKLEPTGLQGSVPSFITRAEPTLAGILKTMGGDFHKTQESLYAMLCQIVGGTTLDTILAVATVEGKLKLFVSRLIKFNEFALIAASEKGAPPTKAYIFDISFLILCSIVQDYGPDAVLEENGDSFFEKWVRECMPHKGVYKSPEQILQKCELPLIDFFIHTLSSPDYDFKNTNMKPHDLCINVSGAIREILFAWEQGSLSAADVKRMLDSLRQKMASLSVCASVWLCSYINVVHQDAFLKPINMVQQFLTPATELEIQIDNFKERSTLMYQIIRKMQRDIHPPSVPKSKPIILSHSIISRQPILEQLHTVWDDIKNRGYLHIDATHIIESLLNTTGPVWFVTNLVKETLKFRYQEDLDRTVDIVLAMFHLDIERCTEALISHVLPQYLYNARLCEELVEPQCATLAKLSVYCIYAALEASNCNKAQFTRKRRHDDSDDLDSISSSNKLRRLNDNSSDGNIYYSQGANATGIVLREPLQSALETLFISFSQLAGKNGDVTPQTQFILEFLVYVVRCGHDRSQVVLQKMASELVPTLIKALPDTFNISLILRLYDLSMPYGRKDTARDLCLLRNMRLRPD
Length975
PositionTail
OrganismOperophtera brumata (winter moth)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Lepidoptera> Glossata> Ditrysia> Geometroidea> Geometridae> Larentiinae> Operophtera.
Aromaticity0.08
Grand average of hydropathy-0.032
Instability index45.54
Isoelectric point6.59
Molecular weight110308.51
Publications
PubMed=26227816

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP04676
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     458.41|     130|     132|     396|     525|       1
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  396-  497 (149.07/119.63)	...............................................KLQKLEPTGLQGSVPSFITRAE.PTLAGILKTMGG...DFHKTQESLYAMLCQIVGGTTLDTILAVATVEGKLKLF.VSRLIKFNEFALIAASEKGAPPTKAYIFDI
  498-  630 (178.56/145.15)	SFLILCSIVQDY.GPDAVLEENGDSFFEK..........wvrecmphK.......GVYKSPEQILQKCElPLIDFFIHTLSSpdyDFKNTNMKPHD.LCINVSGAIREILFAWE..QGSLSAAdVKRMLDSLRQKMASLSVCASVWLCSYINVV
  634-  748 (130.77/103.80)	AFLKPINMVQQFlTPATELEIQIDNFKERstlmyqiirkmqrdihppSVPKSKPIILSHSI...ISR.Q.PILEQ.LHTVWD...DI.KNRGYLHIDATHII.ESLLNTTGPVWFVTN....L.VKETLKF.......................
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     206.86|      68|     720|     151|     245|       3
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  154-  224 (105.58/123.75)	Q...SQEILEKSTTLLNQIVSSdfLLAMFYLARQNDPEEFQEVTKKC........KEI..QAFMMMNTQFKAPVTIHeTIQKIC
  246-  326 (101.28/58.31)	QaliTVNVLANPSADMQQLSSQ..LLMVHRIKSYSLSRLYCELIRSCfislndssKDTskQALWAAFTFLKIPQVMH.YIHNTC
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP04676 with Med24 domain of Kingdom Metazoa
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