Description | Mediator of RNA polymerase II transcription subunit 17 |
Sequence | MDELSFKEIRLSLERPYKDDNGDRIPILFDITPEGRQIYEKKENPTKALGDNLRRIFVERGVDFFDRTKGHEPEQSPLTHDVNTSDTATERPEQDSASTRTMNVEELLKMRAEIVPQLFTSLGEITLARDLLASLLNPSSQSQPENLATDLSAIVVTKPPPIVSVQAFNAQLTIGSKDEALRKAANVFKSAAGSMDRGRIKGEKYWVDALKVRRANWGLNPAPLPFGSATGKGADKTSKDFLISYSLEESPAVFRRQAVARMASDEVSTHGLVFLHRQYTRLRVSVSIVGVDGICITSQNTLTRVDENVPEVALKGAQQEIVEQEIFSLLVQEAGNLPTASARVSERLIVIDAAHATELKFELVCQNISMSEAYLMNFNELCREKCNLIYFALHALLLRRHGFLQAQRLGTMSVGGVTKDNLYPPPVLQPIIDILQYQVFCERIKVEIDKMISALSVAGIQSSLRFNPVGEIGRQLVQLFDNNDGQVIGGEAVLRIDDRHTIRLTFLSPSSLTAHLPQATLTISSIPQLYQLLADEVERCLLYRICEQGRETHGYVGGTWFVDSSRCVGRWEGCVLCVALPYPCRVLTFLPKGTSIYRSERTSLLIVLLFSYTRKHQNKVNSIDILQTLLRDRYFRGSNI |
Length | 640 |
Position | Head |
Organism | Termitomyces sp. J132 |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Basidiomycota> Agaricomycotina> Agaricomycetes> Agaricomycetidae> Agaricales> Lyophyllaceae> Termitomyces> unclassified Termitomyces. |
Aromaticity | 0.07 |
Grand average of hydropathy | -0.175 |
Instability index | 38.78 |
Isoelectric point | 6.63 |
Molecular weight | 71641.21 |
Publications |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364140 |
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro |
Binary Interactions |
Repeats | >MDP04674 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 57.21| 19| 204| 103| 122| 4 --------------------------------------------------------------------------- 103- 121 (33.08/25.29) NVEEL.LK.MRAEIVPQLFTS 308- 328 (24.13/11.16) NVPEVaLKgAQQEIVEQEIFS --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 101.38| 31| 259| 131| 162| 6 --------------------------------------------------------------------------- 131- 162 (49.79/33.47) LLASLLNPSSQSQPENLATdLSAIVVTK....PPPI 393- 427 (51.59/30.18) LHALLLRRHGFLQAQRLGT.MSVGGVTKdnlyPPPV --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) DRIPILFDITPEGRQIYEK 2) LRRIFVERGV 3) MDELSFKEIRLSLERPYK | 23 53 1 | 41 62 18 |
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Designed by Dr. Shailesh Lab & Dr. Jitendra K. Thakur Lab