<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP04670

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMDHGLHEPSVEELERELPAVMDGQISLGDLLSRVMQAIYAELAELAETMPNMSDSARKRTLADWVVKTKKQVVKLYAVTKWTRDAETVQKCMNITAFLMTQNHQFEGAMEGLKYARESLDPARLRNHDLLTSLDVLTTGSYLRLPTCITKSMIPVTPLTDSQVTQTLRDMEDVIRYRLRVSEVVPVEMSQYRIADGRVYFTVPKLFEVSLCLRGAQQDDGWFFVHVMFLINIRGGLTGLQGESHFPRTPTGIMKRHITDEADARLAFYLPLPEEAQNDIPTRPQLPSGVVDTPLVRVYNFLQIMSLSYQLEILWYQAQRMRSLGWADYLTIEMSQNRKVMTVSYWIRQPPPSGRQNRIKLPLLGGTITISIVESHGPSYAGRGPARSPKRRVFARLQRRAKLGVGMPSDEVEGLKFQVLWEPAKGALGVNVLPSIMFDDLLHVDADNLDFESLLCGVIERHAHSILETYQYQLQNGQARTVFSLPGAVTLIKDEGVQALRIHLCADEVVIMTIDSRTGRLNLRDTGDLAAAGRGPHFTGFSEQLNENPQHLITALIRLRLMTITDLAEQKAKYLGLESFRRRNFPPQELHKLGPATRGTLYIQLSNFPNHYLVLVITDERFQYALITTRIITESMYADMIMEDIAWLDFDRIHSEEIVITARSDMCIGKRKRDSDTDIPNESEMRKVDSGFNIETAVLRELYSYCCARVAFMNVERQFKLRGIPFTHVNPTSGSPVTLQLAHIQSSLARSVPALCVQSQDILSGAPAAEAAMPNIRVIPLNWWSEKNAQVVTSVKLKYVQQPMGKTAGTSAVIRPSKRIIYDTTQAVVSFLSENVNTCVDEFLEEWARVSKMVVIAREVAQMAKEGSWDDVRLLSFDLRTVEFAYAKDYTVSISCQDQLSPMGGNFNLRFSRCGRLHARHGQDKDHHHQEFFNPHDDAEPFLRNILRHGHGRLAPSLHRLVTILRDTLPIVVVLEDIRQESMHNNRGVDTFAKAAGWYRLLNIDQRHALDFRLMTGQRVAILDGSFSLFDPTGSRGPAEGGAGEMLGLKPISHFKDIVTNAVRDVVASGSVQPGKVAIIDVGVICHTVDVCQLGKSIHQRLVSHVAH
Length1107
PositionTail
OrganismTermitomyces sp. J132
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Agaricomycotina> Agaricomycetes> Agaricomycetidae> Agaricales> Lyophyllaceae> Termitomyces> unclassified Termitomyces.
Aromaticity0.07
Grand average of hydropathy-0.186
Instability index44.01
Isoelectric point7.08
Molecular weight124704.82
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP04670
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.69|      16|     208|     436|     451|       1
---------------------------------------------------------------------------
  436-  451 (29.25/17.66)	MFDDLLHVDADNLDFE
  635-  650 (31.44/19.50)	MYADMIMEDIAWLDFD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     186.44|      56|     126|     857|     921|       2
---------------------------------------------------------------------------
  857-  921 (85.96/70.24)	REVAQMAKEGSWddVRLLSFDLRtvefaYAKDYTVSIScqDQLSPMGGNFNLRFSRCGRLHARHG
  986- 1041 (100.48/58.07)	RGVDTFAKAAGW..YRLLNIDQR.....HALDFRLMTG..QRVAILDGSFSLFDPTGSRGPAEGG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     100.25|      31|      36|     519|     551|       3
---------------------------------------------------------------------------
  519-  551 (51.31/45.78)	RLNLRDTGDLAAagRGPHFTGFS..EQLNENPQHL
  557-  589 (48.93/35.85)	RLRLMTITDLAE..QKAKYLGLEsfRRRNFPPQEL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      86.56|      25|     126|     141|     166|       4
---------------------------------------------------------------------------
  141-  166 (40.21/31.28)	YLRLPTcITKSMIPVTPLTDSQVTQT
  268-  292 (46.35/30.11)	YLPLPE.EAQNDIPTRPQLPSGVVDT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.06|      12|      36|     343|     354|       6
---------------------------------------------------------------------------
  343-  354 (26.77/14.15)	SYWIRQP..PPSGR
  378-  391 (19.29/ 8.25)	SYAGRGParSPKRR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     117.59|      35|      40|     689|     724|       7
---------------------------------------------------------------------------
  689-  724 (58.30/45.42)	SGFNIeTAVLRELYSYCCARVAFMNVERQFKLRGIP
  732-  766 (59.29/41.27)	SGSPV.TLQLAHIQSSLARSVPALCVQSQDILSGAP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.58|      18|      31|      12|      29|       8
---------------------------------------------------------------------------
   12-   29 (30.62/16.53)	ELERELPAVMDG..QISLGD
   44-   63 (25.96/13.06)	ELAETMPNMSDSarKRTLAD
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP04670 with Med14 domain of Kingdom Fungi
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