<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP04669

Description Mediator of RNA polymerase II transcription subunit 12
SequenceMTELQSDANGSIPLIYESRPPAWLPKVHSCADLGFLGFFPPCAGQEEGLLSETNVKNGFTLNQQVLAETFSAHTIINGGLSSEMTFFKLEALMNEIFARKADNIPSIPSASFRIPTRVTLNDAKRQSWFADLANPHVPLYKLGKSVPHGAKGHDLLDLLQSNNVAIPRAVWFLRVFGANETAGLRNRPSYNPLQYSVDWANVVTSYMKKQLADIALPSAPRPGLNIKQTFKGVLSDIDTRERWVSRFVYCLKLLRTFYSEGLVDSRTFLVWVVQQMTTCNLAQTGFITRLADEYLDGMLGSRPLTRPFLHACLSKLSELRSTSAQAFLRDTEGLLITLVQRLCIAFPDSFISPRMWKTHSLLLIDVLSRNIMVQPGNFHVERSSHEVSQILLENLNDIRKRNEAMLFCGFPIQVSARLGSDVSDIKLLNSISSSTNMNSIQFFSRSTDDEVRFSEKLDMILTWCVTPLQFGDHRPFAAVTLIHNWRMDAADRAARRHSSPPDEFLQDRLFDWLDSSSVANKSENIRSVSLLYGKLVKNELFSYASYIQRLIARGESGLSMTEESESRHRKFLQWIPLSKSTSSLISQRRVILYGVRAREMPEDVNERQIRREIRGVLFDVFGGDPHMPLKSTSALMGSCELLMTSTRFEQVRTLRHWLLPILKKYIASLDTVSSRTLLRAYSISVELMSQTKCYHCVLDLTLCLLEHSATVDLLIAIIDTFHRFSTIWACMNEVRSIVAALDKAHQVWKARGIQSRPLLSLLLDFDDGKYLSNVSRERITTDVTMFTSALQPATAHLDIVPDVLPEILLLAGDPDQDAPSLLANSLWIKYRKSVDWAWKVWDNTVASLRQVPIMTSDEAGRRACAVRYGVLLWHVDQHLAMGLDGEVLRWFLGPGRNEVVVLNTEAWDLLIIVLLYLSVHGALKTTTILQGMVYPAWQQAASVTINQPSPTIETFLRSANDVCRRLLLSDDINDDLPPVDLLELQCIQTRRQDVYAQAHFSRLASSIPVLISLQNNKYISEELRRDSTSLRHLISQNQDFRQGVYRNLDAIREAFERSLRTLDTHNGTLNKHLVAGLRLLLYDINVGDDIELSEWPAVTSLLSPWKIAATMVQMQLILKEMGQDLLRDPTDTSAHANLDRLILMLFSHSMTSEEAFYVGEMARGVDNLVARKFVNNGLRCITERVRDSTLTIPSNSSSAFQRAGELLLILIHVSEPLREDTTLSTILENPAQEDFMEALSSKLVLIESSIVSTSNSDIDEILTQDMILFLRLLQFEMGFRGAWTIKLKETTDRIVSSLFKILLHISSISPTSILYPLMLDTLYYIYDEIPIDPKATPFDPFRHYPSISPADLPLVLPAEHRKQIVSLLPFLSDSCSTSNMVYSQRDTTGNIVLGLPVVNRAWEWIENLGEPAIVDTNQENKDREESARLESKYTVKNSGSLPLEVFDARLTGEGVSGTSASAHDSDHKRLGKLRNFEDCLSKENVFERDWRETRMDLEADIGHPAGRHWTEMDEETGGSSQIAPSKLLKSTPPRCSPAPSNASRSSARGSGASVRPSPQGALNRNSSSTINDILDVDSATTMTPKQPLNNKRRASTSAVASDDEIEIIAGPVPVPSQISKKPRIKPSAKGRPKRK
Length1635
PositionKinase
OrganismTermitomyces sp. J132
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Agaricomycotina> Agaricomycetes> Agaricomycetidae> Agaricales> Lyophyllaceae> Termitomyces> unclassified Termitomyces.
Aromaticity0.07
Grand average of hydropathy-0.172
Instability index49.01
Isoelectric point6.42
Molecular weight183749.06
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP04669
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     672.27|     231|     483|     114|     385|       1
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  114-  385 (338.68/287.01)	IPTRVTLNDAKRQ..SWFADL..ANPHVPLyklgKSVPHGAKGHDLldLLQSNNVAIPRAV..WFLRVFGaNETAGLRNRPSYNPLQ.YS..VDWANVVTSYmkKQLADIAL....PSAprpglnikqTFKGVLSDIDTRERWVSRFVyCLKLLRT...........FYSEGlVDSRTFLVWVVqqmttcNLAQTGFITRLADEYL..D.GMLGS..RPLTrPFLHACLSKLSELrstsaqaFL......RDTEGLlitLVQRLCIAFPDSFisPRMWKTH.....SLLLIDVLS......RNIMVQPGN..FHVERssH
  600-  878 (333.59/195.66)	MPEDVNERQIRREirGVLFDVfgGDPHMPL....KSTSALMGSCEL..LMTSTRFEQVRTLrhWLLPILK.KYIASLDTVSSRTLLRaYSisVELMSQTKCY..HCVLDLTLclleHSA.........TVDLLIAIIDTFHRFSTIWA.CMNEVRSivaaldkahqvWKARG.IQSRPLLSLLL......DFDDGKYLSNVSRERIttDvTMFTSalQPAT.AHLDIVPDVLPEI.......LLlagdpdQDAPSL...LANSLWIKYRKSV..DWAWKVWdntvaSLRQVPIMTsdeagrRACAVRYGVllWHVDQ..H
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     182.92|      61|     236|     996|    1059|       5
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  996- 1059 (94.45/77.63)	AQAHFSRLASSIPVLI..SL..QNNKYISEELRRDSTSLRHLISQNQDFRqGVYRNldAIREAFER...SL
 1231- 1298 (88.47/61.42)	AQEDFMEALSSKLVLIesSIvsTSNSDIDEILTQDMILFLRLLQFEMGFR.GAWTI..KLKETTDRivsSL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP04669 with Med12 domain of Kingdom Fungi
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