<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP04664

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMLLHQADSLLAAQLSVPAPFAVVYARFVPRPHSVPHQAIDRARRQLLAHTTLLGAFLTSVHIGHNSFIYVFAVTDIDATRDATQRLAQLQLDGLAADEPSYFTFDDLYPCSPACSLLSKPCPSCTNTTRGTLLPRKPLRETYSHFLEAIRIRLIDDIAQAASHSRPLRPVTRLKGGFLLGMPSPNNEWCSSWKYRVQSRPLLFCQLQVHLCQSRLIIHPLLHITTFLPLLYSLPVPPGTPITLLPHGTPAFFLTHYNGPTSALTKQFQESLQGLGVGSWSSTSKPSYIIAWINVENKQGEDKGIVLIYPTALCLSFTPSSIPRRPPLEYIPSLPTALQPSPQMSAQPPPSSIPSSTPHTPHTPPLTAYSQPKPVLPSSPSSDSVRAFRALALSKSKDIHQVAAEVAGYVDAVARDREKERERLKRERENNNNSVSTSPKFTRLATASAPTTQSSPISSSAPLLTTPLSLMSQQPVAGTSHPPPPNFYPSPPQADATPHTGPTSPPVFLSAPSSTLEPVPISSEPPPAPVVPPPLQSTFDPFGSTDVSWTTQPQSYLSMNMNMDMDMDMDFEMSMGMDMNMSPFDVNASSDATFGGPSRTGDTGSGGGLDFDDTAFTDDDFSFFDRPSAPAAPVPLSRTMPNATTTAIPTPAAVQTPLSFGASSPLFTTDIPSTTPHNASAPPWVSTFGAAHTASPAVPDLLPPSPGPTPSSHSAPATPTATVHLEPFIRSNSTFDPIPFADYHRVLDGKYAVGKFSLPSPPQYPDDRNDTASPGRVGWRKDYMAATDPRIGVVRKLIGVKRKLAFEHGGKVSKSPISTSSPSWVDDWSSSASTSTPSPDAEIDSDSISSVSSRSPSPSPSPPHSRPTTPPPAYLPLGPTLLSTHFTHSTLLPLSTPLRRPSSPLPLPPPHPHIHPAASALTPVSPAATLGQSKSLEAAAGMVATEVVENPPWAEAWRASTLVAARAQGEVWLADVRAISQLLGSVPGLEGSMTLGSLFCDVGSKRSEKEKEREQKAEEGKGKLKMLEAPMITIGKGDAVIQILPTALRFWQKLGLGPKGGAKNGTVYMLFEDDGEQRMQQVEAWLESVATNYEARHFGTLIPGENSACMRDGVLPLRFDSSFRKTLASLITSLPASQFTILFIVIPMSIMTLASPTLRQIFSAPALTLARPIYNKATFVRAAHASLDVMDRDTFLHVGYQVSQCGKWILAACVDQRGEAHDLGVWLMQTPGESDPEDDLSEMSLVQKVWEFAIQFAKKANVEWRMVFSKLGAIGENELDAWTSWIDSNSRGLRISSFTILAVEPDTPWTFISTQPQTPAPTSPPAKAHNLSRTFSSAKVQPQNIFTDITSTIFATTPYNHLSQFYPLSFSDLGIFLSHVPEDGGQSVTSGFEQSPTLSLPHLLPLLPRSSTTLICIPATHSPTSISMLHLHLLHSIRQPGFISSAQDISSLHTAITHNFHELAVLAYTRWRLNVNPILPIHLAAVEAMQIALSHDQYGADITDSA
Length1505
PositionKinase
OrganismTermitomyces sp. J132
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Agaricomycotina> Agaricomycetes> Agaricomycetidae> Agaricales> Lyophyllaceae> Termitomyces> unclassified Termitomyces.
Aromaticity0.08
Grand average of hydropathy-0.189
Instability index56.44
Isoelectric point6.34
Molecular weight162718.77
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP04664
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|    1500.09|     449|     459|     438|     894|       1
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   75-  377 (297.46/79.63)	.......DIDATRDAT.....QRLAQ......LQLDG.LAadepsyFTFDDL....YPCSPACSL.LSKPCPSCTNTTRGTllP...RKPLRETYSHFLeairirLIDDIAQAASHSRPLRPVTRLKGGF..................LLGmPSPNNEWCSswkYRVQSRPllfcQL..QVHLcqsrliiHPLLH..ITTFLPL........L...........YSLPVPPGTPITLLPHGTPAF..FLTHY...NGP.....TSALTKQF.............QESLQGLGVGSWS....STSKPSYIIAWINVENKQGEDkgivliyPTALCLSFTPSSIPRRPPLeyiPSlptalqPSPQMS..AQPPPSSIPSS....TPHTPHTppltaysqpkPVLP.S...................................................................................................................................................................................................................
  438-  576 (121.30/27.53)	.....................................................................................................................................................................................................................................................................................................................................................................................................................spssdsvrafralalskskdihqvaaevagyvdavardrekererlkrerennnnsvstsPKFTRLATASAPTTQSSPISSSAPLLTTPLSL.MSQQPVAGTSHPPPPNFYPSPPQADA....TPHTGPTSPPVFLS...APSSTLEPVPISSEPPPAPVVPPPL.QSTFDP.FGST..DVSWTTQPQSYLSMNMNMDMDMDMDFEMSMGM
  577-  894 (475.83/141.30)	DMNMSPFDVNASSDATFG.GPSRTGDTGSGGGLDFDD.TA......FTDDDFSFFDRPSAPAAPVPLSRTMPNATTTAIPT..PAavQTPLSFGASSPL......FTTDIPSTTPHNASAPPWVSTFGAAHT.........ASPAVPDLLP.PSPGPTPSS...HSAPATP....TA..TVHL.......EPFIR.SNSTFDPIpfaDYHRVLDGKYAV...GKFSLPSPPQYPDDRNDTASPGRvgWRKDYMAATDP.....RIGVVRKL..........IGVKRKLAFEHGGKVSKSPISTSSPSWVDDWSSSASTSTPS.......PDAEIDSDSISSVSSRSPS...PS......PSPPHSRPTTPPPAYLPLGPTLLSTHFTHS..........TLLPlS...................................................................................................................................................................................................................
  896- 1035 (83.95/16.80)	..........................................................................................................................................................................................................................................................................................................................................................................PLRRPSSP....LPL.......................................................................................pPPHPHIHPAASALT...PVSPAATLGQSK.....SLEAAAGMV...ATEVVENPPWAEAwrasTLVAARAQGEVWLAdvrAISQLLGSVP.GLEGSMT......L.GSLFCD.VGSK..R.SEKEKEREQKAEEGKGKLKMLEAPMITIGK
 1037- 1449 (521.54/144.72)	DAVIQILPTALRFWQKLGlGPKGGAKNGTVYMLFEDDgEQ......RMQQVEAWLESVATNYEARHFGTLIPGENSACMRD..GV...LPLRFDSS.........FRKTLASLI...TSLP..ASQFTILFIvipmsimtlASPTLRQIF...............SAPALT....LArpIYNK.......ATFVRaAHASLDVM...DRDTFLHVGYQVsqcGKWILAA...CVDQRGEAHDLGV..WLMQTPGESDPeddlsEMSLVQKVwefaiqfakkANVEWRMVFSKLGAIGENELDAWT.SWIDSNSRGLRISSFT.......ILA.VEPDTPWTFISTQPQ....T......PA.....PTSPPAKAHNLSRTFSSAK............................................................................vqpqNIFTDITSTIFATTPYNHLSQFYPLSFSDLGIfLSHVPEDG.GQSVTSGFEQSPTL..S....LPHLLPLLP........RSSTTLICIPATHSPTSISMLHLHLlHSIRQPgFISSaqDIS.............................
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP04664 with Med13 domain of Kingdom Fungi
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