<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP04659

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMRKRSKERSFKSTSVSPRQPNPYPHPLIHHRQLQQQHKNQQPTSPATLASPSFSLPQPPQPLQQPLIPQTRHQHHHHHHHHHHQQQQQHKFPSIDHPQNNPHHLNQNNQQYHYHRDSQNHRNYRHSSLRTIPHNSNLPKPPKSDRIPSQSSPPPSTPQPHQTSFPKSISNNNNSNNNNNHQTTSSTTPIKHLHSHSTSTLQSSLPTEEQLGLGGPQSLPYFSTSHIELNPWRGCAPCKWKVPLLESGLPNHPQSNNRDTLTIDDDVEETHYQNSHVEEEEWKIRWAKLSFHTYQETPPADRNLSDELKPQIANQLHSLKLHFVFDSPENPQLGLLVWVYEIPGRLGPKSSNTPPDHSNDQFPPLIDPILKTYQSYENHTPICDSPIIACQAGGYGLIPSFQHTTVLSHGVLSYSQLFPNIFSRSATATSKPLLPHLSHPAKNRTANDFLVDDSNQTNTIPAYANLLRALNQHVIALAVQSPDSTAFPGACPTRWIRWGPDRLLSIPREESLEHLYRNLNHDSTRLLGTILATAPALMVELKCWLSSRVAMCQPSFTARRLAPMPTLQQHNIPPGFPLILAPFPNLRAQYVRMFGRFNHQSLTRSKLGTNAQSPTSSIGRSSWPCDPSIPNSSWISQQKRICRAELKHFEKLKQTWKMAAPFMEAYPESSAAPTINSTQRNLEGWVVCKITSSGAASSETNQGPEIELVWPVDHCLLDLETWIAHVEQYPIPPPAEADQPVTLMSSLSGATCPPRARLASSLILSDFEPTNDLAEDAAATAGKEKTNEKTESPSPSMTVGRAGLGPNRCRGGSGYPSPRYQRHTSTSTAQPSPGPPHLMTPRLSKKRLRDDSDDRFSSQPSATTPAFHLSITALDCGITRRITASNQNDPTTVDFTANGLSDEIGVDIFNDSSGSATTTHLPDPPASQPQASSVPSGRDEQFPSHNISQSSSAALVLSSQLVTTSPQFVSAQKGSGSGSTASTISYNTNLFEQPTPGSLSISGLTPGRLNGFTPDATHNFNNNHVPVQPATLSPPINPNPPLIAAEPNQVDQLAISEHALRTLSLMPSSEPPSLTTVFRFAEPLGYESVHFSRSHTVVDDHYTRRGGKYALPPSPHSLIGPEDEHDGLMDIANQEPLRTARGTPLLVHVSKKLMQAIDPRVKVARTLFSNAMQPTVIDSQQQPFSRVEPLTSSTIASAHGATTGSVVESPATPRSWMPIGSPNGSTDCSTCSDEEDEPDGNAFAQPTETCHRDSCSSTISSCSSDDERMMALDSEYQNDILKKIEQIEGSLKDVLEAHYRSNFFLISSTNVPFQNCVLDDRSRRPPYIPSSVRKKLKNWVSQLAAQLEHDANLEVLLETVLPKTINTSSSSSNSTPAAISDHSQGEERVVLDLASLPAIHGFDYYRSRVDDEYEIQENRHRNNQKKGEEESKLGRQQKVTEDEGDQRPYLIKKLTKLPTSIVVKINEGKQKIAFSLISHLFKYWIKLGFEPVAGQRDSILSVIFPRPRPPQSSSFKPAQPTPQDPTPDDSATENLCDNNKQRWQGLLHLNLPAIHHWLLELANTYKASLFILIRKKAPLLWLTDFCYLFFAVFKYQSGELKKEIEGMISEISGSKMIRHTCLIVVDRLEDMNSLGIGEEEIVGLDGRPVTRLLISRHQLLDDRPASLISFALRLYDSMKIFVHRFRAPGLSFDPPLTSVAVDSVEPLADSEACSSSAGEKVSNSVGSAAGNDANGPMGERRSKRSSDCKLLSGHAFFLTGIQKPTQLNIRWPPSGIDVAARHRILHLGYQVGPHRSWVVVSTVDELGQQHQLGLKFLHPSNLPSQDPPQTHHISKVEDDHRLDMQVVSAVWQVIRKMLLSTNVEWRIVITKLGRLGPLEYEAWCELLSQTLVSSEIAFHVTLASVMLSDIPVLRRGPQVNESGMISPGVTEGGGEAGSELEMGEVQGLEEGEEGGRVGGSAQMVGEEGERMFGGPEPIWVSHESTIRPHSSYNDDGLLSRPSIFSNRPRSVNGTIVHSLSTSYIYHLSCPGQSGLVDMFLPSRNGSGTGGGGGRNSALLGPTLQAQIPPLWPPPPSPPFPISPHTSQLPLGRR
Length2092
PositionKinase
OrganismPuccinia sorghi
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Pucciniomycotina> Pucciniomycetes> Pucciniales> Pucciniaceae> Puccinia.
Aromaticity0.06
Grand average of hydropathy-0.562
Instability index56.63
Isoelectric point6.64
Molecular weight231021.25
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
chromatin binding	GO:0003682	IEA:InterPro
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
cell cycle	GO:0007049	IEA:UniProtKB-KW
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP04659
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             7|    1009.57|     240|     327|      11|     250|       1
---------------------------------------------------------------------------
   11-  164 (257.02/94.51)	.......................................................................................................................................................................................................KSTSVSP................................................................................................................................................................................................................................RQP.N.PYPHPLI..HH.RQLQQQHKNQQPTSPATLASPSFSLPQPP.........QPLQQPLIPQTRHQHHHHH..HHHHHQQQQQHKFP....SIDHP.....................QNNPH..HLN.....QNNQQYHYHRDSQNHRNYRHSSLRTIPH....NSNLPKPPKSDRIPSQSSPPPSTP...QPHQTSF
  165-  250 (81.35/24.61)	PKSISNNNNSNNNNNHQTTSSTTPIKHLH...SH.STSTL.QSSLPTEEQL......GLGGPQSL..PYFSTSHIELNPW..RGCAPCKWKVPLLESGL.PN..................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................
  348-  486 (152.39/52.87)	......................................................................................................hpqsnnrdtltidddveethyqnshveeeewkirwaklsfhtyqetppadrnlsdelkpqianqlhslklhfvfdspenpqlgllvwvyeipgrlgpKSSNTPP................................................................................................................................................................................................................................DHS.NdQFP.PLI..DPiLKTYQSYENHTPICD....SPIIAC.............QAGGYGLIPSFQHTTVLSH..GVLSYSQLFPNIFSrsatATSKP.....................L.LPHlsHPA.....KNRTANDFLVDDSNQTN.......TIPA....YANLLRALNQHVIALAVQSPDS.........TAF
  487-  584 (44.91/10.11)	PGACPTRWIRWGPDRLLSIPREESLEHLYrnlNHdSTRLL.GTILATAPALmvelkcWLSSRVAMcqPSFTARRLAPMPTlqQHNIPPGF..PLILAPF.PN..................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................
  809-  941 (120.31/40.11)	..............................................................................................................................................................................................................lraqyvrmfgrfnhqsltrsklgtnaqsptssigrsswpcdpsipnsswisqqkricraelkhfeklkqtwkmaapfmeaypessaaptinstqrnlegwvvckitssgaassetnqgpeielvwpvdhclldletwiahveqypipppaeadqpvtlmsslsgatcpprarlasslilsdfeptndlaedaaatagkektnektespspsmtvgraglgpnrcRGG.S.GYPSP.......R..YQRH.....TSTST.AQPS...PGPP.........H.LMTPRLSKKRLRDDSDD.....RFSSQ.....P....SATTPafhlsitaldcgitrritasnQNDPT.....tvdftANGLSDEIGVDIFND....SSGSATTTH.......LPDPPASQ..P.QAS...SVP...SGRDEQF
  942- 1143 (230.07/83.78)	P...........SHNISQSSSAALV..LS...SQ.LVTTS.PQFVSAQKGS......GSGSTAST..ISYNTNLFE.QPT..PGSLSISGLTPGRLNGFtPD.....................................................................................athnfnnnhvpvQPATLSP..................................................................................................................................................................................................................................PiN.PNP.PLIaaEP.NQVDQLAISEHALRTLSLM.PS...SEPPslttvfrfaEPLGYESV....HFSRSHTvvDDHYTRRGGKYALP........P.......................SPH..SLI.....GPEDEHDGLMDIANQEPLR..TARGTP.......................................
 2000- 2087 (123.51/41.39)	PSIFSNRPRSVNGTIVHSL.STSYIYHLS...CP.GQSGLvDMFLPSRNGS......GTGG.....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................gggrNSALLGPTLQAQIPPLWPPPPSPPfpiSPHTSQL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     235.61|      72|     505|    1167|    1247|       2
---------------------------------------------------------------------------
 1167- 1247 (119.25/87.19)	FSNAMQPTVIDSqqqpfsrVEPLTSS.TIASAHGATTGSVVESPATPRSWMPIG..SPNGSTDCSTCSDEEDEPDGnaFAQPTE
 1691- 1765 (116.36/66.56)	FDPPLTSVAVDS.......VEPLADSeACSSSAGEKVSNSVGSAAGNDANGPMGerRSKRSSDCKLLSGHAFFLTG..IQKPTQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     187.25|      59|    1581|     280|     347|       9
---------------------------------------------------------------------------
  280-  347 (94.97/70.57)	EWKIRWAKLSFHTYQETPPADRNLSDEL.KPQIAnqLH.SLKLHFVFDSP...ENPQlgllvwVYEiPGRLGP
 1863- 1926 (92.28/48.76)	EWRIVITKLGRLGPLEYEAWCELLSQTLvSSEIA..FHvTLASVMLSDIPvlrRGPQ......VNE.SGMISP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP04659 with Med13 domain of Kingdom Fungi
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