<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP04658

Description Mediator of RNA polymerase II transcription subunit 17
SequenceMVKKHNPVVIAPPAPRLLANDLPPDRDPSEAQKDTLWDFTDAGAQIWKEPQDEASQLTSNLKRLWVERGDFSQLTIESIEKQKSKPAIDSDLPTNNNKGEATTTGSEEESKPSETITVDELWEMRVQMANQLLVMSGELSTGLDLLNTLLAPLAPEAVDSSSLPLPPGGIAPMTHSLDHLSPQPESITLINSSVSLMRKRNATHNASHLLQRAAGELAREAKRSHNEWDTLLTLREAGWNMRPKGAKPGADMSLMGRGAERAAKQIGIAYATTEAAEALRASSFASLEPLEPENHDSTQISLKLPPRPRRRLAITLTLPNQTIERFSPWERYHNLKEMEPLPFAEDLELARAEVLEEEIFGEISKDAQSSATYRTSTSDRSVVVKGFWEDAEISFEMLERDEEAPQMTGEGTGKCRLISALMRLLMISIYRTRRSYAIGITSASPAPTMPKILEPVLDLLVFSIYTRNVRKLILQAVSDLSTTQLEVEAEIDPVLESASEVISMLCERRIFNPAKLDVGGVAALRIMGRRSITFSITCPVVISYWMKDEPLRIGPDQLYSVFMNAINQSMIDLVMDMVDSQEGIRAKRAPTGVLYQSDDRQIFLTPKFRLGAGLTIQAESLAPTTSNNNMIMMAMVMDDKPLERKDQEASSSPANYLGQTGITHWLHSVEYAVIVAMTLHFRLKRDVFPPSRDRTSDLKMTIHLSVTVSRSSN
Length713
PositionHead
OrganismPuccinia sorghi
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Pucciniomycotina> Pucciniomycetes> Pucciniales> Pucciniaceae> Puccinia.
Aromaticity0.05
Grand average of hydropathy-0.326
Instability index52.35
Isoelectric point5.35
Molecular weight79296.61
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP04658
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     252.58|      64|      68|      52|     117|       1
---------------------------------------------------------------------------
   52-  117 (95.00/58.10)	DEASQLTSNL.KRLWVERGDFS...QLtIESIEKQKSKPAID.SDLPTNNNkGEATTTGSEEESKP.SETIT
  119-  188 (85.87/45.22)	DELWEMRVQMaNQLLVMSGELStglDL.LNTLLAPLAPEAVDsSSLPLPPG.GIAPMTHSLDHLSPqPESIT
  200-  248 (71.71/36.62)	RNATHNASHL...LQRAAGELA...R......EAKRSHNEWD.TLLTLR....EAGWNMRPKGAKP......
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     211.61|      63|      90|     507|     571|       2
---------------------------------------------------------------------------
  507-  571 (106.95/70.58)	ERRIFNPAKLDVGgvAALRIMGRR.SITFSITCPVVISYWMKDEPLRIGPDQLYSVFMNAINQSMI
  599-  662 (104.65/63.31)	DRQIFLTPKFRLG..AGLTIQAESlAPTTSNNNMIMMAMVMDDKPLERKDQEASSSPANYLGQTGI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.16|      17|      33|     416|     433|       3
---------------------------------------------------------------------------
  416-  433 (25.18/19.86)	RLISALMRLLMISIYrTR
  451-  467 (28.98/17.78)	KILEPVLDLLVFSIY.TR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      76.12|      24|     291|       3|      26|       5
---------------------------------------------------------------------------
    3-   26 (45.21/26.49)	KKHNPVVIA...PPAP.RLLANDLP.PDR
  293-  321 (30.91/15.78)	ENHDSTQISlklPPRPrRRLAITLTlPNQ
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP04658 with Med17 domain of Kingdom Fungi
Unable to open file!