<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP04645

Description Uncharacterized protein
SequenceMAHINLPRPNHPQSSSENQHSRGPGGDTDEKNSLEIYQLKPPQWRLPIQQNRPDLGYPGLHPTHPGQHEDAITKSLVQWGFTAQMLVSTESFSAHQMIYKKITEEAAFNVTSSALSALIEARRRNSASSSYDTKSTMKVPGRVTLNEQKRENWLRELADTTVPLLKLSKNVPHGFKGEKLLEMLVSRKIDSSRATWYIRLIGLNEINAQRNKNELSHIRYTLSFTCEVCQFLQKQLAEVTVPLQINLSSSTTTLITTSSRLAAMNVRSKPRSSTLSDPETRKHWVAKWNQSRMLLKRLYFESLLDQPTFFKWIVDQLKLANLAQINFLLEIHHSVLDRFNLSSNLVRGFVETCLSQIRFITKQTATSYLSKLERRLRLAVQSAFISCPENFVWPDLWISNKLLLEEIILANFSTGSEEQPSSPPIPLREILKGDFYAVNWRVNELIGDVGIGTGIVGNIFTRRAQLVEILDSYTDYHDCSKLYYKYFLNPSVAGHVPVSFKDKLEVLLSWATTLLRSSDKRVHLVASTLSHVKHDYKKNGDEFQNILVGWLEQVESMEGGDLLVRLFSELSRRNIFSYGAYVQRMVAKGDTECDIVAGKASGVQALLSEWMPLASSKSARDRSNSIKRSPGRDFARNGLMTMIAEFNSATASADYGKFTSLLKRRLDVRQSTSANRKLLAEILPNALVHLVSELAFPNLSGSGSLVCKTAHHPQLASSLLCWGIQLLEACQAYATLFEVIQRMVQIHLGRLEALRSDERTRIDLSLSFQSTFSYLQIICMTALNYKDILEISGQLADLVNCAFAIHVHFRRLVAGTSPAAREFVRCLRSLVLSSNPVDGQILEVLDKEYHPVFDEMMNVGSSPGLTLPSRTREILQAIQYPSAEQISQVVVKYWEEYRSDMDWGPVLWNSLITAIKIYSQEEIDEPQITCDNWAEFREVVMQFCEDLDMLYEEGLVGCLIRAGYTNYPHPDDETLFALPTPTISDSKMTLEKEEGEENEGISTAIPTLKSLFLHNPRSLCRNLRRLLVELMSCGLVSIDLALEEYATRPLADDLPQLLVNLYGDGSSEPPRTPPSTTQVEEALRQVKEIYDLVKEVLCEQRLDRCSQGSCPSPDKEWAVMINPSQSRSDGHTSLIMNQDAAAEISNKLKEVEQEITEYVRACRLDVERKLWFEQGHEASAFCSRLLLSLLISIKTISELSSDPEASAENPTGQQQQPEPFQQPMMTRILDVFESLRRTVCQGSNLLRQQIPTQAAVFLDPILEFVNKNDMGTLFHTKLIHSIDELLPYPQSTEVINQKYPYLELIFKATCIFNHAARTRQFQLHIRLLMSNNHPPSMPVTKDVPLDLAGTLGSLVEVMAKRLHLTDSKDASPFFLDCLPSQVAEALIIKLSLYLGMSICKLLGPNHSDSALEILRIHHICRCITTLTNQLTIRTYQANDDMTVKVVGGCGPLGCNATVESYMSYWQQLKSGLSLLNSRLATSDPTTLSPKRIEYRIMRALLHSIQVVLWSLPGLTQHLGTLKQSIAEIWIEISLRVQGDSALQNQIMDTIGVLLFPTVPDDSCLTATVGILRKRFRWLYLPLLNMDSAANLVPSNRLKYLLGSSLRGSSTTFQERLADGSVKFVEEKPWEELEKMDMSGPGFISIEALRCQTLGHVAQIPAPKMSITKLPKLKRAKGDEEEAIAEGGFRQRGERGTDQRMGVVVLNDDEDGGEEEASEEEEEEEELMRGERDSFEHELMTDGLSTIPLHFLRSLCPPASRLSGRDWLVTIEQQKLVETKQAEEEQTRLQKQQQQQQQQQQHHQQGLNAGTSQESGRTKKRKGLGLSPSPVVEPIISASSTTTGPTLRSARSTRKKSSANVAPTIPPTTLANSSKRSKKR
Length1879
PositionKinase
OrganismPuccinia sorghi
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Pucciniomycotina> Pucciniomycetes> Pucciniales> Pucciniaceae> Puccinia.
Aromaticity0.07
Grand average of hydropathy-0.297
Instability index54.18
Isoelectric point6.35
Molecular weight211498.30
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP04645
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.96|      14|      77|     155|     168|       1
---------------------------------------------------------------------------
  155-  168 (24.18/12.81)	RELADTTVPL.LKLS
  234-  248 (19.77/ 9.24)	KQLAEVTVPLqINLS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     407.41|     198|     364|     621|     836|       3
---------------------------------------------------------------------------
   60-  146 (71.40/36.52)	LHPTHP....GQHEDAITKSLVQWGFtaQMLvstESFSAHQMIYKKITEEAAFNVTSsaLSAL.IEARRRNSASSSYD.TKSTMKVPGRVTLN..............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................
  621-  697 (53.33/34.69)	...........................................................................................................................................................eqkrenwlreladttvpllklsknvphgfkgekllemlvsrkidssratwyirliglneinaqrnknelshirytlsftcevcqflqkqlaevtvplqinlssstttlittssrlaamnvrskprsstlsdpetrkhwvakwnqsrmllkrlyfeslldqptffkwivdqlklanlaqinflleihhsvldrfnlssnlvrgfvetclsqirfitkqtatsylsklerrlrlavqsafiscpenfvwpdlwisnkllleeiilanfstgseeqpssppiplreilkgdfyavnwrvneligdvgigtgivgniftrraqlveildsytdyhdcsklyykyflnpsvaghvpvsfkdklevllswattllrssdkrvhlvastlshvkhdykkngdefqnilvgwleqvesmeggdllvrlfselsrrnifsygayvqrmvakgdtecdivagkasgvqallsewmplassksarDRSNSIKRSPGRDFaRNGLMTMIAE.FNSATASADYGkfTSLLKRRLDVRQST.......SANRKLLAEILPNALVHLVSE.LAFP
  699-  836 (153.25/129.99)	LSGSGSlvckTAHHPQLASSLLCWGI..QLL...EACQAYATLFEVIQRMVQIHLGR..LEALrSDERTRIDLSLSFQsTFSYLQIICMTALNykdilEISGQLADLV.NCAFAIHvhfRRLVAGTSPAAREFV.RCLRSLV........LSSNP................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................
 1150- 1289 (129.43/73.20)	..................................................................................................EVEQEITEYVrACRLDVE...RKLWFEQGHEASAFCsRLLLSLLisiktiseLSSDP.......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................easAENPTGQQQQPEPF.QQPMMTRILDvFESLRRTVCQG..SNLLRQQIPTQAAVfldpileFVNKNDMGTLFHTKLIHSIDElLPYP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      91.13|      28|      77|     944|    1020|       4
---------------------------------------------------------------------------
  990- 1020 (44.41/98.36)	LEKEEGE..ENEGISTAIPTLKslfLHNPRSLC
 1726- 1755 (46.72/ 9.69)	LMRGERDsfEHELMTDGLSTIP...LHFLRSLC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     138.23|      45|      84|     279|     327|       6
---------------------------------------------------------------------------
  279-  327 (72.24/52.77)	ETRKHWVAKWnQSRMllkRLYFES.LLDQPTFF....KWIVDQLKLANLAQINF
  363-  412 (65.99/37.56)	QTATSYLSKL.ERRL...RLAVQSaFISCPENFvwpdLWISNKLLLEEIILANF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     107.63|      38|    1066|     510|     579|       7
---------------------------------------------------------------------------
  171-  211 (56.73/23.10)	VPHGFK..GEKLLEMLVS..RKIDSSR.ATWYIRLigLNEInAQRN
  532-  574 (50.90/46.59)	VKHDYKknGDEFQNILVGwlEQVESMEgGDLLVRL..FSEL.SRRN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     159.20|      52|     733|     849|     905|       9
---------------------------------------------------------------------------
  849-  905 (86.94/67.52)	YHPVF..DEMMNVGSSPGL..TLPSRTREILQAIQypsaEQISQVVVKY.....WEEY.RSDMDwGP
 1579- 1640 (72.26/42.10)	YLPLLnmDSAANLVPSNRLkyLLGSSLRGSSTTFQ....ERLADGSVKFveekpWEELeKMDMS.GP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP04645 with Med12 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) EQQKLVETKQAEEEQTRLQKQQQQQQQQQQHHQQGLNAGTSQESGRTKKRKGLGLSPSPVVEPIISASSTTTGPTLRSARSTRKKSSANVAPTIPPTTLANSSKRSKKR
2) MAHINLPRPNHPQSSSENQHSRGPGGDTDEKNSLEIYQLKPPQ
3) RAKGDEEEAIAEGGFRQRGERGTDQRMGVVVLNDDEDGGEEEASEEEEEEEELMRGERDSFEHELMTDG
1771
1
1674
1879
43
1742










Molecular Recognition Features






MoRF SequenceStartStop




1) RTKKRK
1816
1821