<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP04642

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMPDILNRSPATPFSALHATHVLHLPKDRIYIHRYALSAVPVASIKDVVEDKLEKFWRDIADRAENGKGMLEAPVAAIVGQIERELWCFTCKDDGIWPPDGVNEIQPPLPPLVPLDLLSCPDHSSSYKCLSESSCDVTLNLEGETGKAWGLLANALIETLAWKAGSRIILRDSGVVPFTPPFKPSLYPFTSSSLLLSLLPSPSPILSSPLYPTATHTLLPLSLPSILVSTALTPTPAQIARLNQTFDTLLGPAWKTGREQRVAREFVFGSGVEAEIISEMQEKREEEGWGVFWVPLLKKGSESEEKGVLTVWPIHLALPRLSDASTPNFSLGHNSSSTTAPLLSTQLKQFGGTEEREQGLMQIAHSLFDFFTSYREPSVPPEGDGGQVDDQDPDHDNEAGLVDNDAEMNETDGEGSNLRETGAGARGDIKMEPSPKEGSDIDDLFSSPSPTSTPIVNMSSQPQSNKSPQPQQVQDQSNNVQNGEEDFMSSLVSVQDPSPPSRSQMMGIRDREREREVEVEITEDDFAFFDSPVPEVGDGIRMDVDTSMDGGISQSLSDGAVDHRGETGEEPLIEQGKGILTEEMMESASPKSAMAGQGDLMLVPLVRNDMEVDGILPEPLLSPPVKTATKESPSSPLPVPFQPPTPPTILEASPKAPEQLVFQSRNLTSPSIPLVPAVASNNSLVPLSFQPLPLLPSSHSSSSYPYGNTYGYAPPSPASTPESSILARLASYQTQYQTRPGFEAPSASQDQEATGRLSSKRKSTYADAWFPLSGGDDDGDGEDGDENDMDSQAYTCPPTPISQMEEMAVEVESDAGSGGAGEVTGIDVDSRATGLTGMKDQERESKEDDEEIEWKGMKCIGSEWVVLRDQPGFVQAKKDTENEIGWKVESVWDEAWGTLPSAVSGKKDSVKTKEKLKEKKVKDVNWTKVVQEIITNRALRKSVLDSEDEHEQNSAWMGTLLEGDPLCEVFGSDILPVNLPQPQVNAASPSTPHIIRLSIAALSYWSQLGLEPQGGKKDVKIFIVCRDSDEALGKMLGEGVKLGWEEERFGKAEFSGIVKGKMEDFGELATGITDQSSGSVNTIVNTIVCLLTPPSQIPLNIYSSPVPNSPNTLFIPVPTPTNPSISFVHEQYLTLGHTAYDRLPTLLRPVYVRGEPLRVPQEDEWMQCPAWVLARKEAVKPEFVMTWPVDEYDVLNRWRMWHICYDVVSSTSPGPDAVIVWVGDDRGETGHVRVFEDVGGWKEGMEKICAYGREIAGRWNLEWRLSVCRAGIMAKEELQAWKDILKGKTWPITLLTSETPSPLNPSDQMTPPKVRAIANIGPSILSDSSTRIIDIALSAQLTILPLPLPLELSSDKGSPQTVYPRRTFLLTTHALNVSQHYTTKYHILSHQAPDGRKDQEDGGIAAEIAEEYHRLGCLARERWEGQGWWMQSDGARHYWKRDKHRHTVVKVATLANIKLYNVTSACSQWEKAS
Length1472
PositionKinase
OrganismCryptococcus gattii serotype B (strain R265) (Filobasidiella gattii) (Cryptococcus bacillisporus)
KingdomFungi
Lineage
Aromaticity0.07
Grand average of hydropathy-0.432
Instability index55.99
Isoelectric point4.75
Molecular weight161548.65
Publications









Function






Annotated function


GO - Cellular Component
GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP04642
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.99|      18|      18|     615|     632|       1
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  618-  638 (27.54/11.15)	PLLSPPVKTATKESPsspLPV
  639-  657 (28.45/11.79)	PFQPPTPPTILEASP..kAPE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     107.11|      25|      27|     702|     728|       2
---------------------------------------------------------------------------
  459-  476 (26.01/ 9.98)	SQ..PQSN....KSPQPQQVQDQS.....
  702-  728 (43.10/28.49)	SY..PYGNTYGYAPPSPASTPESSilARL
  730-  756 (38.00/19.25)	SYqtQYQTRPGFEAPSASQDQEAT..GRL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     831.26|     321|     655|     260|     701|       3
---------------------------------------------------------------------------
  260-  697 (438.02/351.23)	RVAREFVFGSGVEAEIIS..................EMQEKREEEGW......GVFWVPL........LKKGSESeEKG..VLTVWpiHLALPRLSDAstpnFSLGHNSSSTTAPLLSTQLKQFGGTeereqglmqiaHSLFDFFTSYR.EPSVppegdggqVDDQDpDHDneaglvDNDAEMNeTDGEGSNLRETGAGARGDIKMePSPKegsdIDdlfsSPSPTSTPIVNMSsqpqsnkspqpqqvqdqsnNVQNGEEDfMSSLVSVQDpSPPSRSQMM..GIR.DRERER..................EVEVEITED......................DFAFFDSPVPE..VGDGIRM.....DVDTSMDGGIS....QSLSDG..AVDHRGETGEEPLIEQGKGiLTEEMMESASPKSAMAGQGDLML.VPLVRNdmevdGIL.........pepllsppvktatkespsSPlpvpfqpptpptileaspkapeqlVFQSRNLTSPS...................IPLvpAVASNNSLVPLsfqPLPLLPSS
  807- 1154 (320.37/162.46)	AVEVESDAGSGGAGEVTGidvdsratgltgmkdqerESKEDDEEIEWkgmkciGSEWVVLrdqpgfvqAKKDTEN.EIGwkVESVW..DEAWGTLPSA....VSGKKDSVKTKEKLKEKKVKDVNWT...........KVVQEIITNRAlRKSV........LDSED.EHE......QNSAWMG.TLLEGDPLCEVFGSDILPVNL.PQPQ....VN....AASPSTPHIIRLS.......iaalsywsqlglEPQGGKKD.VKIFIVCRD.SDEALGKMLgeGVKlGWEEERfgkaefsgivkgkmedfgELATGITDQssgsvntivntivclltppsqiPLNIYSSPVPN..SPNTLFI.....PVPTPTNPSISfvheQYLTLGhtAYD.RLPTLLRPVYVRGE......................................................................................................................................................
 1187- 1353 (72.87/18.42)	.............................................................................................................................................................................................................................................................................................................................................................PVDEydVLNRWRMwhicyDVVSSTSPG.P....DAVIVW..VGDDRGETGHVRVFEDVGG.WKEGMEKICAYGREIAGRWNLEWrLSVCRA.....GIMakeelqawkdilkgktwpitlltsetpSP........................LNPSDQMTPPKvraianigpsilsdsstriIDI..ALSAQLTILPL...PLPLELSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.06|      17|      21|     193|     212|       4
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  193-  212 (27.63/20.80)	LL.LSLlpsPSPILSSPLYPT
  217-  234 (24.43/10.05)	LLpLSL...PSILVSTALTPT
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP04642 with Med13 domain of Kingdom Fungi
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