<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP04635

Description Mediator of RNA polymerase II transcription subunit 5
SequenceMTSSEQWGAFLHQCLMRRIDATEFKTLSKILFRRCPIAEGTLLDVLLEIRLATGIKWDPLLPLYIDCLCKMGKVQTSTVLTSLLKYSSIHDKPQSPDSEAVQSKKALKCYTLMTDIRVIQDAMLSVSTGSTPKSLADAVGIFSAIIDWIQAVVAWHNNHIDPNQQTGGLMSSPDAVSLFESLGILLTALSGTGKGIEVLSSDSHEALKVKLGQALSAYLPLCMEVSLPLRNRLDSLQKGFNLYGEPPNKSLQSMMDNVNVNALQFEASVMDGPVINSRAGLYIYINAMLVGRPLVDDSMLLNYLTNRYGGHYDVLVEEVITATFDVLSNALYRNESSRTMFMFRSFLVNKLPSFFAAMMAASMVSLPMEMCISHALSRLDPNTFPSFSQMFAMQGNTVLSEVRPEFLFACASHKLIPESSIERLLGENPMQTPPVGYNKDDLVSQINTNQERAEQLVSELESTEGNAGAIVAAITEVMHNLCNQKETVTLKNICNSLSRRPQALDVILLFRSAKQVLQPLCTLLDSWHWDEDQGESQPVYDEFGSILLLVLTFKYRYDLRPYDLGITSNDSFILKLLDCGASSQKLDDLSEKQNKNLGAWITALFIAEGISEETMSACSPQEFYLLVTTLFNQSLTACEAGKLEFDTLKGGFEYLLEPFLLPSLVVALTWLGNHIWETESDPTIPLKTLQSLVNPSSISGDAREIHKTVLNITARSLDEQLKDIRSRHPNRADIKPILDVLEPCLSFQRTGSCHRTELDSWTTHSPGGLLGSIRSTFQGLVLWSTSPGVSMAPHSYTHRQLVAGIRMLGSTRVLTAIVDELKVQSETGNADLALDIAVTMICAPLAESFAVEQSNYHPVDPNKDPLPRCPILTLRDALNSQHENVPKLSEKDPLRAEVIVRLYRRVDALMTLTSQMPNLDMSNIIQDMQLGVEDHGQMDLEPTSAGHDVGDDDAANLNRMLDNAAAAAAAGLDSGMGQSMGGALDTSIDDVLNAADMAVGNPEFLDLDMEGMF
Length1013
PositionTail
OrganismAspergillus nomius NRRL 13137
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Aspergillus.
Aromaticity0.06
Grand average of hydropathy-0.038
Instability index48.76
Isoelectric point4.86
Molecular weight111553.45
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP04635
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.01|      17|      27|     858|     874|       1
---------------------------------------------------------------------------
  858-  874 (33.36/23.38)	PVDPNKDPLPRCPILTL
  886-  902 (28.66/18.94)	PKLSEKDPLRAEVIVRL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      70.50|      24|      27|     563|     586|       2
---------------------------------------------------------------------------
  563-  586 (39.77/25.76)	DLGITSN...DSFILKL.LDCGASSQKL
  588-  615 (30.73/18.21)	DLSEKQNknlGAWITALfIAEGISEETM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     384.71|     122|     296|     375|     541|       3
---------------------------------------------------------------------------
  407-  534 (195.00/180.06)	LFACASHKL...IPESSIERLLgeNPMQTPPVGYNKDDLVSQINTNQERAEQLVSELESTEgNAGAIVAAITEV...MHNLCNQKETVTLKNICnslSRRPQALDVILLFRSAKQVLQ....PLC..TLLDSWHWDEDQG
  635-  768 (189.71/97.89)	LTACEAGKLefdTLKGGFEYLL..EPFLLPSLVVALTWLGNHIWETESDPTIPLKTLQSLV.NPSSISGDAREIhktVLNITARSLDEQLKDIR...SRHPNRADIKPILDVLEPCLSfqrtGSChrTELDSWTTHSPGG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.31|      17|      32|     349|     365|       5
---------------------------------------------------------------------------
  349-  365 (30.74/18.88)	NKLPSF..FAAMMAASMVS
  382-  400 (27.58/16.23)	NTFPSFsqMFAMQGNTVLS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.95|      14|      15|     228|     241|       6
---------------------------------------------------------------------------
  228-  241 (24.34/13.66)	PLRNRLDSLQKGFN
  246-  259 (25.62/14.74)	PPNKSLQSMMDNVN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      77.79|      24|      28|     957|     982|       8
---------------------------------------------------------------------------
  957-  982 (36.21/31.82)	LNRMLDnaAAAAAAGLDSGMGQSMGG
  988- 1011 (41.58/29.24)	IDDVLN..AADMAVGNPEFLDLDMEG
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP04635 with Med5 domain of Kingdom Fungi
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