<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP04632

Description Mediator of RNA polymerase II transcription subunit 12
SequenceMIPHSSAGVQSWGHPLRAVNSGSGHVDASQSVGPSDPQFEKLTTPVPQPQPRQPAVIDLTTSGGDAQEVEPPPKRLRLDLPAAPSARDASPAPGSGGELRSTPGTGGSKPPSLSWRNRPVWSFQTMLSEVPGSNVMNEEDATAVAQGGKPASPPSLPVLPWKYVPESLGANPTMSRASSPVKEVQTIPYRIETPSVAPVLKGEKVADFSPWTGNHPEDVLNEQTAKQGHYDRTQVSQNESNTARPSLYAQLKHRSGLQMLSSVFAAALEKRQNHSLVTAPSTFKPPPRVTLTDNKREAWLRDLANPSVPLRKLSRTIPHGIRGKALLDQCLNKGIPVSRAVWLAKCVGANEIRAFKRKGTSGTLALGLEAKWVRDWTATVQQFLEGVLGACGSAQWKMKMTYAVSLTARLFFERLLDHDQYLGWFLSSLEAAPVNTVPVWLLMLGIYWDNIMRYRKRGRRLAELLLEKLRQVTQPEKVGPLQPLVDRLSLYVRRLVLEHTSSVVLPGSWEKYKELVSSCLNLKDNVHKTIYQNVCERNSRLQLPKNHQGTAERSPQQRVIQLFDSIRSAHDISSASAACLKTLENKAVLISKLLEWTATPFRYGLCRVYTGVRLLRKWKMSGIDVDSFILSFLADVRVTSALNMENIYHIISELVRSQTFSVGRYLQWLMAKGVTNTSQPVSSDLCLLKQLPVNRLPEHVRNLRNTLLYRAGIPAMEEDSAIAELKVSIAQRLPNIFGAEMGSAMPIEPSQTNPTWAVKSEIGQWIRRGVAGHCRDSPRKLSVVSVTVDPGVSALTPDEFYSVREILETFGDLSMLADILKQATRCDDDVVLASVADTVNCHFDCFCVIGATADLFRGLVESYARLKRLGNASLDLLFSLIELGLRIPSEFNTVALLRQDLTRLESKSALAAPSPLSDSIPLALSDVDPSFQAKLNQLLSSGGGMDESTMDTVFYSLIHILEGSGSPAKLSANETARYLAYLRPFQPKHFDAMLIRWICGLLKSSTPSMSRVLPPLIGVGCVTIHAFVFLVKKLLQSEKVAAVIPNLTGLRVELLQLIVPLLSGKSKYADLVTYRFHVAQQEFFMKHPQETLDIICDAVALVDSGAGLDSRQPNIAGSAIELLDILLTQNPEVTVQYCLQGFIGKHSTSTTVLQRALDNLLGFDSLTGPPAMSEAEKVVRMTDDFSLPFCQLKLQMLFNAESGRDVGNGIVDVMFKAAVEDTRSKGSNWVGFVGLMSQDVIRQIRERAERALFSIPLFEEHLEAHGPSGTAKSLETAKLYLTIIEKLAYSVPEAGVQSVAPVLIEKMDLLLHRLVIMQTNFNNVTANRHGAATTQILQSRSNFEKALAFWFSAFLRMIVIHRSAFTMPSPAPKPNGLQEQSRLLISILCISLARLPDSVIRLFPVTDYFPHPIPSQGYRACPGILLQTHALDVAASLIDTFPDEARQHCARFLKEKCPPFLQYQNDSRFIYLLGPMSDAAAPNSLQAASLPSPAAAGSTPTPTPSGALPGAPSNPQTPAVTPAGSSASLSEGINCVASHLRLQYRGRVMGPYPVRPWELLEDAAPIVGVNDTAVSLKYFDARRVRA
Length1586
PositionKinase
OrganismAspergillus nomius NRRL 13137
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Aspergillus.
Aromaticity0.07
Grand average of hydropathy-0.100
Instability index50.20
Isoelectric point8.91
Molecular weight174076.29
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.


Component of the srb8-11 complex. The srb8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The srb8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP04632
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     267.86|      66|      71|      33|     103|       1
---------------------------------------------------------------------------
   24-   96 (103.70/62.29)	GHVDASQ.svGPS.DPQFEKLTTPVPQPQPRQPAVidlttSGGDAQEVEPPPKRLRLD..LPAAPSAR..DASPAPGSG
   97-  158 (91.84/46.63)	GELRSTP.gtGGSkPPSLSWRNRPVWSFQTMLSEV.....PGSNVMNEEDAT.........AVAQGGK..PASPPSLPV
  159-  215 (72.33/35.07)	LPWKYVPeslG.A.NPTMSRASSPV....................KEVQTIPYRIETPsvAPVLKGEKvaDFSPWTGNH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.96|      19|      70|    1035|    1058|       2
---------------------------------------------------------------------------
 1035- 1058 (25.87/25.36)	LQSEKvaaviPNLTGLRVELLQLI
 1108- 1126 (32.10/19.17)	LDSRQ.....PNIAGSAIELLDIL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     112.92|      35|      71|    1159|    1195|       3
---------------------------------------------------------------------------
 1159- 1195 (56.48/46.30)	NLLGFDSLTGPPAMSEA.EKVVRMTddFSLPFCQLKLQ
 1228- 1263 (56.44/38.86)	NWVGFVGLMSQDVIRQIrERAERAL..FSIPLFEEHLE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     110.23|      35|      75|     449|     485|       6
---------------------------------------------------------------------------
  449-  485 (51.52/39.93)	DNIMR..YRKRGRRLAELLLEKLRQVTqPEKvGPLQPLV
  524-  560 (58.71/36.26)	DNVHKtiYQNVCERNSRLQLPKNHQGT.AER.SPQQRVI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     202.80|      65|     352|     328|     399|       8
---------------------------------------------------------------------------
  328-  399 (102.18/95.09)	DQCLNKGIPVSRavwLAKCVGANEIRAFKRKGTSgtlALgLEAKWVRDWTATVQQFLEGVLGA.CGSA..........QWKMK
  684-  759 (100.63/70.81)	DLCLLKQLPVNR...LPEHVRNLRNTLLYRAGIP...AM.EEDSAIAELKVSIAQRLPNIFGAeMGSAmpiepsqtnpTWAVK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     217.63|      66|     352|     603|     673|      11
---------------------------------------------------------------------------
  603-  673 (101.50/76.58)	YGLCRVYTGVRllRKWKMSGIDVDSFiLSFLADVRVTSALNMenIYHIISELVRSQTFSVGRYLQWLMAKG
  955- 1020 (116.13/71.42)	YSLIHILEGSG..SPAKLSANETARY.LAYLRPFQPKHFDAM..LIRWICGLLKSSTPSMSRVLPPLIGVG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      78.74|      15|      15|    1490|    1504|      12
---------------------------------------------------------------------------
 1472- 1486 (23.75/11.55)	LLGPMSDAAAPNSLQ
 1490- 1504 (26.94/14.34)	LPSPAAAGSTPTPTP
 1508- 1522 (28.04/15.30)	LPGAPSNPQTPAVTP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     100.33|      30|     164|     240|     269|      14
---------------------------------------------------------------------------
  240-  269 (51.15/36.09)	SNTARPSLYAQLKHRSGL.QMLSSVFAAALE
  405-  435 (49.18/34.38)	SLTARLFFERLLDHDQYLgWFLSSLEAAPVN
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP04632 with Med12 domain of Kingdom Fungi
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