<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP04631

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMPGVVMDNTDIGGAGQGPAAHDPRNNMRSLTPDISRNSTLGDSHAERVHINGMTKNAADPSQAEDASAVKIIPTKSTELPELPHITQGFFSFSKLINRSVQQSWNDLSDLITEMADIQVSPQDSSSLQLPASGKSYGNQSPGNLRKKARILDFAHAKRAEFIKLLVLSQWGRQAADVSKLIDLQNFIRTRHQAYMGALQWIGDMKRDLVQAQVANPDLRTALEVLSKGKVSSMSDLGYKPPRSLTGKHTLKRLQKINRIISVRLALHDSVPRAFQTYSIRDGRVTFVVPNEFELDLSIGQEDESSQLYFVDVRFLFNPSSPIPKGRIFNEFDVKINDALRNGGLAGCFDFLHSLVLTNKINILFKQAMELARGLWYDVLRVELLHRTLVVHYWTQKVGAKSWLEIGIKSGRIYGENDGYRYPYLDLRWIRDGQEVDSEEIEFNTESLSMECILRSVIALHISHILSSAYRIISESPLYSAGRLSLQAQLTRTEPGDCGLAIQLTESRHLSVSIEPMSGASIISATPSAQDRLDNDRSFDKSSAEDIVARVARLRCMAAIDEIESNVRMLGFETVNPRSLKIDFRRMFPNNVLRFSFFWHHLWERNWIVAATSSMDGDNWWVVQLQTTTTAESHSVFDANTHISATLRSAQVISGTFFPVSQNISYPSFADLGHYLSGILAVHTNARYLVDLQSVDFYPPLQRLVIEPDLHVPEIFMRYEVATIPEAFRIALPSGLKRRVRTKDTIRLAFHGIDPCKKAAIIVAYGNLLIPTKTFSALNSTWDHSLVFQKRGTGFAIRLLAPPGRPVIPKLMENLQRLDCVLSIFESLQRKKMEPRSLSLSHVTFAYGPEKDLLATLNIETTMPPSSIEYDPILLASRTKSLFRLRLGLSLEFPNPHRRIQKSIESTLNHSTTDAGLDTVAELLLLTLPLMRALDRILMNPSNKQPLKVQVTVRNAKTFQIHYPAQSFRFQLVATHHLSHMVWILKELSSPKEGSSQDQLKLKLRERLYNSKGDGWRGLGNGVVAETDKVGNLLTELDKCFEASGSVGLADSTPEAKANGSKSFVQQSTAENGNLEGILSESAKLIPAPNVTIRHKAGDTTQNADIIMID
Length1109
PositionTail
OrganismAspergillus nomius NRRL 13137
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Aspergillus.
Aromaticity0.07
Grand average of hydropathy-0.229
Instability index47.97
Isoelectric point8.79
Molecular weight124044.30
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	ARBA:ARBA00003669
ECO:0000256	RuleBase:RU365082

GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP04631
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     135.93|      41|      44|     714|     757|       3
---------------------------------------------------------------------------
  714-  754 (70.12/46.19)	IFMRYEVATIPEAFRIALPSGLKRR.VRTKDTIRLAFHGIDP
  760-  801 (65.81/35.17)	IIVAYGNLLIPTKTFSALNSTWDHSlVFQKRGTGFAIRLLAP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      75.28|      17|     147|     279|     295|       4
---------------------------------------------------------------------------
  279-  295 (31.06/23.63)	IRDGRV.....TFVVPNEFELD
  407-  425 (19.25/11.43)	IKSGRIygendGYRYP...YLD
  429-  443 (24.97/17.34)	IRDGQ.......EVDSEEIEFN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     132.59|      43|      47|     992|    1038|       5
---------------------------------------------------------------------------
  992- 1038 (64.96/51.12)	EGSSqdqlKLKLRERLYNSKGDGWRGLGNGVVAETDKVGNLLTELDK
 1041- 1083 (67.63/43.51)	EASG....SVGLADSTPEAKANGSKSFVQQSTAENGNLEGILSESAK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      59.04|      15|     375|     599|     613|       7
---------------------------------------------------------------------------
  599-  613 (30.10/20.63)	HHLWERNWIVAATSS
  975-  989 (28.94/19.55)	HHLSHMVWILKELSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.74|      11|     621|     313|     323|       9
---------------------------------------------------------------------------
  313-  323 (22.69/14.53)	RFLFNPSSPIP
  935-  945 (22.05/13.88)	RILMNPSNKQP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      74.19|      25|      46|     837|     865|      12
---------------------------------------------------------------------------
  837-  865 (29.67/28.52)	LSLShVTFAyGPEKDLLAtlNIETTMPPS
  886-  910 (44.53/23.76)	LGLS.LEFP.NPHRRIQK..SIESTLNHS
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP04631 with Med14 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) MPGVVMDNTDIGGAGQGPAAHDPRNNMRSLTPDISRNSTLGDSHAERVHINGMTKNAADPSQAEDASAVKIIPTKST
1
77










Molecular Recognition Features






MoRF SequenceStartStop




NANANA