<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP04629

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMDFPGGSVTNIRVLDGFSNIYWRIYTEDPNITNLPGEAPANGFTILKHLSRLKDLELRLRNSDCLVSSYPRRLGLWVFSATPEFESVASLRSDESKGEQSRLIVGSSTLKVSASGSVTPRELVKNLSTDPQTAGSSTGSQRPQATPTSTRRVDSYSSSVAIYAAFISAITGSLNLQLIRRSSAIPLGSRTLFTVVERDYYETSRIVNDDLSSISALTTIQVQLTSAGKLTVSLQTTSQHGIAPLCRPGESPSDVCDIAPGADIWLSPSGSVARLVSTSPGPPNASSPYPSTGGIGTDNLGAAGRKQWKANVLDWLRNFGLPIDTVDETAWVEIEIWEPFYSRLAGETLRLNEDNSSTLPLKRVLWPAVYCFRRTKSASPGSSQWMESACPVVSDPLDFAENWRVVEKPKHDETSPKPPSSHPEQQSRNTEPSSATTDILEGIESLSRASEYPDLQTISLVYPTPPDGAAVMGLNLAGASDTFAEEPELVPSLLQNQNKPKYYEQFTAKDRSDADPSAGFGPLGGLAVGSGLYDTNEDDDLFGDMDERDFGTKGITDADFNFFDDPSFAAMDTDDPADDAQEMPDMANLEAAEAHPTVSEDAILEDIPAQKTPAEDLEVTQASPDEVTPKVQHEHLDAEEITEAASPYIEQNQTISPPLSPVEIKRILLPEPNGDSHVPTKGSRKQSYYNPVAFKPNMSAWDQKYGADGKFRFTTAGPSASKVYTNSDIPTVGMPRRRIKKYPTAGASAMGLDGHASPSSEGHYLQTVSDSSSDTSDDSDNSASESDAPPLLSRKRKRACSNSVSSPALSQVKSLGEGDQEIPIHRPEHSIFLGNLLSTFSDWSMTGYFSLAENRLFPVLTRKDMQIQIAQLFVDQITQSSLDHKLDGGFCLSDLEAKAYSVQSFLEEEGVLGSIERLDLNSWISLQDNEQASPAPNGTVARQPSQRKETGKGLITKLSPPHLRVRRGKEYLEALPPAISFWETFGLEPADGPKDISAYCIHPQIAADAANVFLERLGLLYASCNLGKHVRGCRSSAFEWGLCSWDVGPLDTAQFLPAMQSLKVICEELGTALLKGSPSNDSLVIYIINPFAHASALVDICSAFWCLFQKYITDTGKQQARQLNEVVLQIIPISFIMSTGSVVVPPQTQYLNLALEIYSRCPPKALQSSLVNCAPPVLLAEPLPRTISFRLASEKTSPLQEGKCLHIAYSKSQDQRWIGVAWSDNSGALQRTISYNLRYRNASAVRSISDVRSEIWVATKDIVDRIQARWKVFVVSTEPVDQDEVDAWTGFIEQYNKANSIPLELTILSVNTAPDLYIEPPFLPMSMSVFNPQTSSTPVATPNASGNVFSPDQWGTAPTPPSGGNAPANASTPTEPTLEAESESVLTDICDESWGVVLSHRLNNSPHLTEYRPALASGYLLRRKGDTDGDGVYAMTLNLIYTQRPSSCETILRETLGMYRDLGTLARARGTRTVQRNTLPWHIATAVRAQELLSHVL
Length1496
PositionKinase
OrganismAspergillus nomius NRRL 13137
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Aspergillus.
Aromaticity0.07
Grand average of hydropathy-0.350
Instability index53.99
Isoelectric point4.92
Molecular weight163174.60
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



ECO:0000256	RuleBase:RU364134

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP04629
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     439.93|     124|     133|     448|     577|       1
---------------------------------------------------------------------------
  448-  515 (87.08/41.74)	............................................................................ASEYPDLQTI..SL....VYPTPPDGAAVMGLNLAGASDTFAEEPELVPSLLQNQNKPK.YYEQFTAKDRSD.ADP
  516-  646 (167.26/105.32)	SAGFGPLGGLAVGSGLYDtnEDDdlfGDMDERDFGTKGITDADFNFFdDPSFAAMDTDDPAD.............dAQEMPDMANLeaAE....AHPTVSEDAI...LEDIPAQKTPAEDLE.VTQASPDEVTPKvQHEHLDAEEITEaASP
  652-  789 (185.60/100.87)	QTISPPLSPVEIKRILLP..EPN...GDSHVPTKGSRKQSYYNPVAF.KPNMSAWDQKYGADgkfrfttagpsaskVYTNSDIPTV..GMprrrIKKYPTAGASAMGLD..GHASPSSEGHYL..QTVSDSSSDT.SDDSDNSASESD.APP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.37|      14|      15|     946|     960|       2
---------------------------------------------------------------------------
  946-  960 (20.79/16.21)	RKETGKGLITKLsPP
  963-  976 (25.58/15.09)	RVRRGKEYLEAL.PP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      32.99|       9|      15|    1340|    1350|       3
---------------------------------------------------------------------------
 1340- 1350 (13.59/13.51)	TPNASGNvfSP
 1358- 1366 (19.39/10.58)	TPPSGGN..AP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     104.11|      30|     135|     252|     287|       4
---------------------------------------------------------------------------
  252-  287 (47.48/32.75)	SDVCDIAPGADIWLSPSGSvarlvSTSPGPPnASSP
  393-  422 (56.64/26.14)	SDPLDFAENWRVVEKPKHD.....ETSPKPP.SSHP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      40.04|      13|      15|    1260|    1273|       5
---------------------------------------------------------------------------
 1260- 1273 (19.55/14.12)	DIVDR..IQArWKVFV
 1277- 1291 (20.49/ 9.79)	EPVDQdeVDA.WTGFI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.50|      18|     137|    1155|    1187|       6
---------------------------------------------------------------------------
 1170- 1187 (33.91/36.16)	VNCAPPVLLAEP.LPRTIS
 1309- 1327 (30.59/ 6.73)	VNTAPDLYIEPPfLPMSMS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     210.01|      63|     151|    1041|    1104|       7
---------------------------------------------------------------------------
 1041- 1104 (105.68/72.26)	LCSWDVGPLDTAQFLPAMQSLKVICEELGTALLKGSPSNDSLVIYIINpFAHASA...LVDICSAFW
 1190- 1255 (104.34/66.31)	LASEKTSPLQEGKCLHIAYSKSQDQRWIGVAWSDNSGALQRTISYNLR.YRNASAvrsISDVRSEIW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     153.37|      47|     288|      50|     100|       9
---------------------------------------------------------------------------
   50-  100 (68.19/54.10)	SRLKDLELRLrNSDClVSSYPRRLGLWvfSATPEFESVASLRSDESKGEQS
  341-  387 (85.18/51.42)	SRLAGETLRL.NEDN.SSTLPLKRVLW..PAVYCFRRTKSASPGSSQWMES
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     131.02|      38|     645|     150|     197|      10
---------------------------------------------------------------------------
  150-  187 (60.72/28.79)	RRVDSYSSSVAIYAAFISAIT.GSLNLQLIRRSSAIPLG
  796-  833 (60.87/28.89)	KRACSNSVSSPALSQVKSLGE.GDQEIPIHRPEHSIFLG
  865-  885 ( 9.43/ 8.54)	........QIQIAQLFVDQITqSSLDHKL..........
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      67.26|      21|     955|     216|     247|      12
---------------------------------------------------------------------------
  223-  243 (36.14/42.26)	LTSAGKLT....VSLQTTSQHGIAP
  911-  935 (31.12/ 7.97)	LGSIERLDlnswISLQDNEQASPAP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP04629 with Med13 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) DDPSFAAMDTDDPADDAQEMPDMANLEAAEAHPTVSEDAILEDIPAQKTPAEDLEVTQASPDEVTPKVQHEHLDAEEITEAASPYIEQNQTISP
2) KVYTNSDIPTVGMPRRRIKKYPTAGASAMGLDGHASPSSEGHYLQTVSDSSSDTSDDSDNSASESDAPPLLSRKRK
3) LSPVEIKRILLPEPNGDSHVPTKGSRKQSYY
4) QTSSTPVATPNASGNVFSPDQWGTAPTPPSGGNAPANASTPTEPTLEAESES
5) RELVKNLSTDPQTAGSSTGSQRPQATPTSTR
6) SDTFAEEPELVPSLLQNQNKPKYYEQFTAKDRSDADPSAGFGPLGGLAVGSGLYDTNEDDDLFGDMDERDF
7) WRVVEKPKHDETSPKPPSSHPEQQSRNTEPSSATTDILEGIESL
563
721
658
1332
120
479
402
656
796
688
1383
150
549
445










Molecular Recognition Features






MoRF SequenceStartStop




1) FGTKG
2) KYGAD
3) MPRRRIKKYP
4) SRKQSYYNPV
5) VEIKRILLPE
549
703
733
682
661
553
707
742
691
670