Description | Mediator of RNA polymerase II transcription subunit 20 |
Sequence | MPITGVFFIPSNPNASTAFATVTERLHSSLADEPIPVGRWALEHKLMRDTPSCLPASASQRPTQPRYMQFLSLTYFPNHGFIYTSPPPEKVPHTQHGAGTPGTVAPGAPSPASSTPIPQQTATPTQAPAPNSQDHSSMVMTTVPLPACSTLFQHFVYACQPFWCHRHTVTVPGGVVYDVGDFRVRIGDVRQTQPAARVRGTVVEIEWKGPSLVTSIASLFNQSKKAFGGPRDSGVPDDDGDSGIDMAFPEGLEEADIDAEYAATATLIREFWARLGIQGAREAILVQDIGRESKEQLRKLKQLGDQKARQPSTSIVGSGQQDEDPDPEAGVDVARQFMEIFRFNR |
Length | 345 |
Position | Head |
Organism | Aspergillus nomius NRRL 13137 |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Aspergillus. |
Aromaticity | 0.08 |
Grand average of hydropathy | -0.386 |
Instability index | 48.81 |
Isoelectric point | 5.73 |
Molecular weight | 37518.71 |
Publications |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364152 |
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro |
Binary Interactions |
Repeats | >MDP04624 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 153.73| 47| 72| 50| 104| 1 --------------------------------------------------------------------------- 50- 104 (66.82/55.21) TPSCLPASASQR......PTQPryMQFLSlTYFpNHgFIYTSPPPEKvpHtQHGAGTPGTV 123- 175 (86.91/41.94) TPTQAPAPNSQDhssmvmTTVP..LPACS.TLF.QH.FVYACQPFWC..H.RHTVTVPGGV --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 53.35| 15| 83| 233| 247| 2 --------------------------------------------------------------------------- 233- 247 (29.55/14.08) SGVPDDDGD..SGIDMA 318- 334 (23.80/10.26) SGQQDEDPDpeAGVDVA --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) PDPEAGVDVARQFMEIFRFNR 2) RKLKQLG | 325 298 | 345 304 |
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Designed by Dr. Shailesh Lab & Dr. Jitendra K. Thakur Lab