<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP04617

Description CMGC/CDK/CDK8 protein kinase
SequenceMMKSYRERRDRERITIQDNYLILGFISSGTYGKVYKAQPRNDTANMVAIKKFKPDREGEVTYTGISQSACREIMLNREILHENVTALQEVMLQDKSIYLVFEYCEHDFLQIIHHHSQSRTSIPEGTLKSLLWQLINGVNYLHANWIVHRDLKPANILVTEHGVVKIGDLGLARSFHSPIQSLYASDKVVVTIWYRSPDLLLGARHYTASIDIWSIGCIMGELIYLRPIFKGDEAKPDPHHHHHHHHSNKKNVSGNHSSGVPFQKDQLSKIFDILGLPTKEDWPAMVHLPEYPHMTRFEKTTNTLRQWYISKTTSYRVINQTTPSTTGGVGGGGTEGYQLMNELLRYDPTKRVSALAALEHPYFRTSQPLPRPDCYFNHHHSSSNSTPSIVNYPPKYPTRRVSPDDSDPKMVPISNRPLLNPLHTTDRNPSSLAPKKASNHLSSNGLGSNSRPSSSSKRPRFD
Length462
PositionKinase
OrganismPuccinia striiformis f. sp. tritici PST-78
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Pucciniomycotina> Pucciniomycetes> Pucciniales> Pucciniaceae> Puccinia.
Aromaticity0.08
Grand average of hydropathy-0.605
Instability index41.71
Isoelectric point9.33
Molecular weight52613.00
Publications









Function






Annotated function


GO - Cellular Component
GO - Biological Function
ATP binding	GO:0005524	IEA:InterPro
protein kinase activity	GO:0004672	IEA:InterPro

GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP04617
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      82.36|      23|     125|     277|     300|       1
---------------------------------------------------------------------------
  277-  300 (39.60/28.84)	PTKEDwPAMVHLPEYPHMTRFEKT
  403-  425 (42.76/25.08)	PDDSD.PKMVPISNRPLLNPLHTT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.85|      17|     125|     113|     140|       2
---------------------------------------------------------------------------
  113-  129 (32.32/10.34)	HHHSQSRTSIPEGTLKS
  242-  258 (32.53/10.49)	HHHHHSNKKNVSGNHSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.41|      17|      17|     177|     193|       3
---------------------------------------------------------------------------
  177-  193 (30.05/20.58)	SPIQSLYASD.KVVVTIW
  196-  213 (26.36/17.21)	SPDLLLGARHyTASIDIW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     112.00|      32|      62|     364|     396|       6
---------------------------------------------------------------------------
  364-  396 (60.02/39.33)	RTSQPLPrPDCYFNHHHSS...SNSTPSIVNYPPKY
  427-  461 (51.98/29.21)	RNPSSLA.PKKASNHLSSNglgSNSRPSSSSKRPRF
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP04617 with CDK8 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) DCYFNHHHSSSNSTPSIVNYPPKYPTRRVSPDDSDPKMVPISNRPLLNPLHTTDRNPSSLAPKKASNHLSSNGLGSNSRPSSSSKRPRFD
373
462










Molecular Recognition Features






MoRF SequenceStartStop




1) IVNYPPKYPTRRV
389
401