<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP04606

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMTTRDNTITSPASSSSSPEPNQQPSKKVNDSNHYSTRKPTQFDRETLDQIDRTELQRVWGPHLVPLQFVIQRTIAQVFNELQNLSQISPNVEDHERKKRVIDFVVHSRRQLIKLLVLVKWSSNSLPVHKIMSIVGFLQRQNNQFERNVNILKASKENFHSARMRNYDLPTALQVLTNGYPTLPGSLTDQFDSKPKLTDSEVIKIMHDLNELISFRLASSEVIPREFRSYRIYDGRVVFKIGGMFECSLTLGGGELDSQWYLLHVEFLFKVTGPRGKDFMGIPQGAVKNQIIESGNRIMAPVDLPTESDPDPKPPERPIMKSFAYLRDLCLNYQLEALHYQASQLGRSAWASHTKVLITTDRRNLTIMYWSHARPVSIPVPRPGQQLPKNPPQPTPQGTLTIRRHIELHSPSRRRVTDFLNEYPLKDKHPPSDGEDEDFGASQTERLQVIWKPIELTNATGLTPEILINQFKIRPNDQVIFTKRPAENGLSSMVELELRMDELCLDSILQRVVRVHTDCTLRRAFFDLTRIDRPLTSTPTTTRAVPYFASVRLVPWDEVLPHNSERFAKSIEVVLHARHTVEILIDQFSGRFRLQSTVATPPSASTSHTSDNSTSDSLGSGCFSSFNNTRLSFSDVKINANPSTLRDVLVRLKSDILLDQIEFKARLLGMKTTRNLPIQLQNEELKKLTHQININNHNRTVITHHINQLTMFCKLSNFDHHYLMIMVSENGIKCALIIVNQYRITSGNSSNSLAWNVHSVSPVDVPPFAGDSDDDGGALDQFTLSRTQLRYVYHYCLIQVTLNQLKGPLMNNGISYEHILPLTRSIIQRQRSHQEQRSIHTTNHSSSSSIQLPTFHPSHEVTGLLSIPLQGFLKPSFLNNSIRNRDHKNIFDCENLAVRVVLNPASHFGVQVEVQFKFNPGKLSAEELEKIMRSKEINFNKRVISHYLMKQQIKLKSQSNSIPTLVPSSSGSIPMPSLRSQGETSLSIPNSDSQADPQKNGNHDDEDSDEDEEPLSKRISTTTTTTTATATTTTAATTTTTTRLEPNTKPKVTHPITENSRQEGGQDEEDEEDERYALLHDMIDELLIDSDQWSIDPDSNHFSMRFLHFTTQVDQIYNLSILKFFHLLHSSSGSSASTSSSSLIP
Length1144
PositionTail
OrganismPuccinia striiformis f. sp. tritici PST-78
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Pucciniomycotina> Pucciniomycetes> Pucciniales> Pucciniaceae> Puccinia.
Aromaticity0.07
Grand average of hydropathy-0.502
Instability index49.00
Isoelectric point7.16
Molecular weight129740.04
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP04606
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     203.03|      54|     114|     451|     506|       1
---------------------------------------------------------------------------
  451-  506 (86.10/64.18)	KPIELTNATGLTPEI.LINQFKIRPNDQVIFTKRPAENglSSMVELELRMDEL...CLDS
  532-  565 (36.24/18.81)	RP..LTSTPTTTRAVpYFASVRLVPWDEVL..PHNSER......................
  568-  624 (80.69/53.49)	KSIEVVLHARHTVEI.LIDQFSGRFRLQSTVATPPSAS..TSHTSDNSTSDSLgsgCFSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     144.23|      44|     114|     173|     216|       2
---------------------------------------------------------------------------
  173-  216 (74.67/39.82)	QVLTNGYPTL.PGSLTDQFDSKPKLTDSEVIKIMHDLNEL.ISFRL
  289-  334 (69.56/36.62)	QIIESGNRIMaPVDLPTESDPDPKPPERPIMKSFAYLRDLcLNYQL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     150.69|      31|     120|     837|     867|       3
---------------------------------------------------------------------------
  376-  401 (42.60/18.89)	SIPVPRPGQ....QLPKNPPQPTPQGTLTI.
  837-  867 (57.41/28.01)	SIHTTNHSSSSSIQLPTFHPSHEVTGLLSIP
  960-  988 (50.68/23.87)	SIPTLVPSSSGSIPMPSLRSQGETS..LSIP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      93.52|      27|     230|     758|     785|       4
---------------------------------------------------------------------------
  758-  785 (44.58/34.97)	SVSPVDvPPFAGDSDDDGGALDQFTLSR
  990- 1016 (48.94/33.65)	SDSQAD.PQKNGNHDDEDSDEDEEPLSK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      65.78|      19|    1064|      30|      50|       5
---------------------------------------------------------------------------
   30-   50 (28.36/26.57)	DSNHYSTRkPTQFDREtLDQI
 1097- 1115 (37.42/24.00)	DSNHFSMR.FLHFTTQ.VDQI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      98.17|      29|     241|     676|     705|       6
---------------------------------------------------------------------------
  676-  705 (47.83/35.65)	PIQLQNEELKKLTHQININnHNRTVITHHI
  919-  947 (50.34/32.63)	PGKLSAEELEKIMRSKEIN.FNKRVISHYL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP04606 with Med14 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) IPVPRPGQQLPKNPPQPTPQGTLTIRRHIE
2) MTTRDNTITSPASSSSSPEPNQQPSKKVNDSNHYSTRKPTQFDRETL
3) QSNSIPTLVPSSSGSIPMPSLRSQGETSLSIPNSDSQADPQKNGNHDDEDSDEDEEPLSKRISTTTTTTTATATTTTAATTTTTTRLEPNTKPKVTHPITENSRQEGGQDEEDEEDERYALLHD
377
1
957
406
47
1080










Molecular Recognition Features






MoRF SequenceStartStop




NANANA