<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP04605

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMSPSSASSSSHSNNNNSSNSHHSRNNNNRFYQQQLQQQQYQQNYHHQQQQLQQQQHHHHQQQQQQQQFQNQHHQFLFQQQQQQQHIQSQPQLLHRHPHQLQQAHSLLHHPHHHPHHHHHQQHNLQQQAYQQNTHHPLPSSSSSSSSAAALANSNHTPRQSSAYSQPNLHQRQLQKNQQAQPSTSPILSRANHQSPSYVRSQSISAISPLSSPSFSLPPPPVIPPPLAQQPQRLHQQHHHNKFTSDSRSNQHHRDPSRRSYNRQSSLRTNLALPHHPSLPKPPHSDRTPTIPIHPPPTSTQAHHHTQPSSSSAVPSSVAATAAAPFPKPNTNNQNPPTAIRHVHSTSTSTLPSSLAPEEQHGLGGPQSAGYFSSSAAELNPWRACSPCKWKVPLVESGLPSVPTPSDTLSIDEEVDETNCLSSNVEEDEWKIRWAKLWLVAQETPDRSPRAGLDELKPQIANQLHSLSLHFVFDSEEEAGAHRDRRQPGLVVWVYEIPGRLGPKRSTTENPRTNDQPPPLIDPKSKSYQSFENQTAISDPSPIKACQSVISHGVLSYSQLFPNVFSRSTTSNTKPLLPHLSHPAKNRAANDLLADDSSQTNTIPAYANLLRALNQHVITLAVQSPDSTAFSSASPTQWIRWGPDRLLSVPRDESLESLYRNLNKDSTRLIGSILTSPPALVVELKCWLSSRVAMCQPSFTARRLAPMPSLQHHTIPPGFPLILAPFPNLRAQYVRMFGRFNHQSLAPSKPGSSSQSPNSPIGRSSWPAEPSQLNASWISQQKKICRAELKHLEKLKQTWRMAAPFLEAHPDAHPTSTTDVHPRRLENWVVCKITTSGAAPPKNNQNSEIELVWPVDHCLLDLETWLASAEQNTTPATESDQAATLMTPLSGICLPRARLANSLMLSTYESTDELAEDAGSYIDWVAQERELQRRAAATVGKERTNEKTASPPSMVGGRAGLGSNRGRGSNYPSPRFQRHTSTSTARASPVPSHLITPRLSKKRSRDDYDDRSSSIYPFTTPTFIPSSVAPFGSGIIPRNATASGQDDSPTVDLASNSLGDENRMDLCDDSSGGPATTTHDPPQSSSAALVLSSQLVNTSSQFPTPGSLSISALTPAHLNGSTPDTAHHFNNNHPSTQPALYSSPITSDRLLTSTEQPAGPSHVDQLAVSEHALRTLSLISSSEPGPSAQLFRVVEPVGYESVRFSHAHTVVDEHYTRRGGKYALPPSPHSFSGQEDEQDDNMMEIVDQELFRTAQGPLLVHVSRKLMRAIDPRVKVARTLFNSTTRAIASDSKQQPFSRVEPLTSSAIGSTTQGATGYGESPATPRSWVPIGSPNDSSDGSNCSDDEDEQDGNGFNRTIDAHDYGSCSSSTSTTSSSSDDEDDRRTMPADNEYQDAIATKIQRFERSLNNVLEDHYRSTFFFIHPSPINPQSNLSIDHRSPKPNHIPVPLRKKLKNWVTQMAGQLEHDPNLEVLLETLLPSSSSKSATTASSTSIARQTQERIVVMDLASVPIINGFDYYRSRVDDEYEIQEDRNRINNQSLKRGTENQPKINNKQQQQQSKVIKEDGVDQRPYLIKKFTKSPASIIVKINEGKQKITFSLISQLFKYWIKLGFEPVSGQRDFILSIIFPRPPTSCSSSTTFKYSQSKRKSNDHSSDNLMDDHNSVKIHKKQQGLLHLNLLSVHQWLLELAHTYKSCRLGELTIGKIHESKYRAGDIKKEIEGMIGEIEGSKRRGRHTCLIIVDRIEEMKSLGVGESEIVGIDGRPVTRLLISRQQLLDDRPSSLISFGLRLYDSMKIFVHRFKAPGLSFDPNLSRSTQSRDEIECSDSDDCPEKLQQQPNQTDGRSQSKEEIQDKMDIDHPGVSNKQPTKLLSSHAFFLNGIQKPTQLNIRWPPSGIDVTTRHRILHLGYLVAPHRDWVLVSSIDELGQQHQLVLKFTAVDSTSKLMRNHHLQIVKTVWNVLKKIILATNVEWRIVITKLGRLKPVEYEAWCELLSETIPVSEIAFHVTLSSVMFRDIPILKRRVDTEDPSGLMKTSENEAGIIGGEGSDLEMGEVEVMEEGEEGTVKGGGGSNSSAPISKTEEESVAGVEKLFGGPEPIWVSHESTIRPHSSYADSRGSSHEDAEGRSINGTIVHSLSTSYIYHLHTPFHSAPTTGSTGHPGGQRFRFDILGTAATPASVYQANLFQHREEIIHSIVQLSKLKSLRTGFPPSTHSHSLSDNGDKEEEDGFNNGNVDLLLPVHLNSLRIIGNQLVRNWTRLSQLFSTNEDDDEEEDDDSINPTPVDQSGILNQTPREVGNLDGTVADDGGDGDDDGDGEIDADGVADISDLEDEDTEL
Length2338
PositionKinase
OrganismPuccinia striiformis f. sp. tritici PST-78
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Pucciniomycotina> Pucciniomycetes> Pucciniales> Pucciniaceae> Puccinia.
Aromaticity0.06
Grand average of hydropathy-0.718
Instability index58.14
Isoelectric point6.37
Molecular weight259308.20
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
chromatin binding	GO:0003682	IEA:InterPro
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
cell cycle	GO:0007049	IEA:UniProtKB-KW
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP04605
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             7|     290.18|      32|      32|      32|      63|       1
---------------------------------------------------------------------------
   32-   63 (65.77/25.61)	QQQL......QQ.QQYQQNYHHQ...QQQ......LQQQQ..........H..................HHH...QQQQ
   65-   87 (33.92/ 9.70)	Q............QQFQ.NQHHQflfQQQ.......QQQQ..........H..........................IQ
   89-  120 (40.09/12.78)	QPQLlhrhphQL.QQAHSLLHHP.............HHHP..........H..................HHH...HQ..
  121-  159 (43.34/14.41)	QHNL......QQ.QAYQQNTHHP............LPSSSsssssaaalaN..................SNH...TPRQ
  165-  202 (33.48/ 9.48)	QPNL......HQ.RQLQKN...Q...QAQpstspiLSRAN..........H..................QSPsyvRSQS
  224-  256 (45.42/15.44)	PPLA......QQpQRLHQQHHHN...KFT......SDSRS..........N..................QHH...RDPS
  261-  306 (28.16/ 6.83)	NRQS......SL.RTNLALPHH.....PS......LPKPP..........HsdrtptipihppptstqaHHH...TQ..
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      85.05|      25|      27|    1807|    1832|       2
---------------------------------------------------------------------------
 1807- 1832 (43.12/28.16)	LSFDPNLS..RStQSRDEIECSDSDDCP
 1835- 1861 (41.92/22.75)	LQQQPNQTdgRS.QSKEEIQDKMDIDHP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     154.94|      31|      32|    1319|    1349|       3
---------------------------------------------------------------------------
 1029- 1055 (30.01/11.97)	PFGSGiiprN.....ATASG....QD....DSPTVDLA..SN
 1056- 1088 (35.33/15.76)	SLGDE....NrmdlcDDSSGGP...ATTTHDPPQSSSA..AL
 1301- 1328 (42.08/20.58)	PLTS............SAIGSTTQGATGYGESPATPRS..WV
 1329- 1361 (47.52/24.46)	PIGSP....N.....DSSDGSNCSDDEDEQDGNGFNRTidAH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.38|      14|      17|     696|     710|       4
---------------------------------------------------------------------------
  696-  710 (22.91/17.35)	PSFTArRLAPMPSLQ
  716-  729 (28.47/16.72)	PGFPL.ILAPFPNLR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      89.01|      26|      36|    2263|    2290|       5
---------------------------------------------------------------------------
 2263- 2290 (42.37/30.67)	QLFSTNEDDDEEEDDDsiNPTPVDQSGI
 2300- 2325 (46.64/27.74)	NLDGTVADDGGDGDDD..GDGEIDADGV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      68.63|      16|      17|     514|     529|       6
---------------------------------------------------------------------------
  284-  300 (26.02/13.30)	S.DRTPTIpIHPPP.TSTQ
  514-  528 (23.60/11.12)	..DQPPPL.IDPKS.KSYQ
  529-  546 (19.01/ 6.99)	SfENQTAI.SDPSPiKACQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      92.90|      31|      37|     356|     391|       7
---------------------------------------------------------------------------
  355-  389 (51.63/32.16)	APEEQHGLGG...PQSA.........GYFSSSAAELNPWRAcspcKW
  391-  433 (41.28/19.36)	VPLVESGLPSvptPSDTlsideevdeTNCLSSNVEEDEWKI....RW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      80.41|      28|      37|     940|     970|       8
---------------------------------------------------------------------------
  940-  970 (42.73/30.78)	KERTNEKT..ASP.PS.MVGGRagLGSNRGRgSNY
  976- 1007 (37.68/17.36)	QRHTSTSTarASPvPShLITPR..LSKKRSR.DDY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.35|      13|      16|    1921|    1933|       9
---------------------------------------------------------------------------
 1921- 1933 (22.16/14.14)	VSSIDELGQQHQL
 1940- 1952 (21.19/13.12)	VDSTSKLMRNHHL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     152.61|      36|      37|    1122|    1158|      11
---------------------------------------------------------------------------
 1096- 1120 (29.83/10.87)	.NTSSQF........P.TPGSLSIS..ALTPAHLNGS......
 1122- 1158 (60.30/35.07)	PDTAHHFN....NNHPSTQPALYSS..PITSDRLLTSTEqPAG
 1160- 1197 (36.31/15.36)	....SHVDqlavSEHALRTLSLISSsePGPSAQLFRVVE.PVG
 1203- 1224 (26.18/ 8.49)	FSHAHTVV....DEHYTRRGGKYAL..P...............
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.64|      16|      35|    1573|    1607|      13
---------------------------------------------------------------------------
 1550- 1565 (25.95/43.61)	KINNKQQQQQSKVIKE
 1588- 1603 (25.69/17.34)	KINEGKQKITFSLISQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      39.44|      13|      31|     567|     579|      14
---------------------------------------------------------------------------
  567-  579 (22.25/11.47)	STTSNTKPLLPHL
  583-  595 (17.19/ 7.10)	AKNRAANDLLADD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     158.39|      35|      35|     824|     858|      15
---------------------------------------------------------------------------
  791-  821 (28.90/14.00)	......LEK...LKQTWRMAAPfleahPDAHPTSTTD.VHP...
  824-  856 (52.71/32.87)	......LENWVVCKITTSGAAP.....PKNNQNSEIELVWPVDH
  857-  890 (44.35/26.24)	CL..ldLETWLA...SAEQNTT.....PATESDQAATLMTPLSG
  892-  923 (32.43/16.80)	CLprarLANSLMLS.TYESTDE.....LAEDAGSYID..W....
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.26|      13|      20|     470|     482|      22
---------------------------------------------------------------------------
  470-  482 (22.19/11.98)	FVFDSEEEAGAHR
  492-  504 (25.07/14.56)	WVYEIPGRLGPKR
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP04605 with Med13 domain of Kingdom Fungi
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