<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP04604

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMSPSSASSSSHSNNNNSSNSHHSRNNNNRFYQQQLQQQQYQQNYHHQQQQLQQQQHHHHQQQQQQQQFQNQHHQFLFQQQQQQQHIQSQPQLLHRHPHQLQQAHSLLHHPHHHPHHHHHQQHNLQQQAYQQNTHHPLPSSSSSSSSAAALANSNHTPRQSSAYSQPNLHQRQLQKNQQAQPSTSPILSRANHQSPSYVRSQSISAISPLSSPSFSLPPPPVIPPPLAQQPQRLHQQHHHNKFTSDSRSNQHHRDPSRRSYNRQSSLRTNLALPHHPSLPKPPHSDRTPTIPIHPPPTSTQAHHHTQPSSSSAVPSSVAATAAAPFPKPNTNNQNPPTAIRHVHSTSTSTLPSSLAPEEQHGLGGPQSAGYFSSSAAELNPWRACSPCKWKVPLVESGLPSVPTPSDTLSIDEEVDETNCLSSNVEEDEWKIRWAKLWLVAQETPDRSPRAGLDELKPQIANQLHSLSLHFVFDSEEEAGAHRDRRQPGLVVWVYEIPGRLGPKRSTTENPRTNDQPPPLIDPKSKSYQSFENQTAISDPSPIKACQSVISHGVLSYSQLFPNVFSRSTTSNTKPLLPHLSHPAKNRAANDLLADDSSQTNTIPAYANLLRALNQHVITLAVQSPDSTAFSSASPTQWIRWGPDRLLSVPRDESLESLYRNLNKDSTRLIGSILTSPPALVVELKCWLSSRVAMCQPSFTARRLAPMPSLQHHTIPPGFPLILAPFPNLRAQYVRMFGRFNHQSLAPSKPGSSSQSPNSPIGRSSWPAEPSQLNASWISQQKKICRAELKHLEKLKQTWRMAAPFLEAHPDAHPTSTTDVHPRRLENWVVCKITTSGAAPPKNNQNSEIELVWPVDHCLLDLETWLASAEQNTTPATESDQAATLMTPLSGICLPRARLANSLMLSTYESTDELAEDAGSYIDWVAQERELQRRAAATVGKERTNEKTASPPSMVGGRAGLGSNRGRGSNYPSPRFQRHTSTSTARASPVPSHLITPRLSKKRSRDDYDDRSSSIYPFTTPTFIPSSVAPFGSGIIPRNATASGQDDSPTVDLASNSLGDENRMDLCDDSSGGPATTTHDPPQSSSAALVLSSQLVNTSSQFVSAQQESGSGSTASTISYNTNLFEQPTPGSLSISALTPAHLNGSTPDTAHHFNNNHPSTQPALYSSPITSDRLLTSTEQPAGPSHVDQLAVSEHALRTLSLISSSEPGPSAQLFRVVEPVGYESVRFSHAHTVVDEHYTRRGGKYALPPSPHSFSGQEDEQDDNMMEIVDQELFRTAQGPLLVHVSRKLMRAIDPRVKVARTLFNSTTRAIASDSKQQPFSRVEPLTSSAIGSTTQGATGYGESPATPRSWVPIGSPNDSSDGSNCSDDEDEQDGNGFNRTIDAHDYGSCSSSTSTTSSSSDDEDDRRTMPADNEYQDAIATKIQRFERSLNNVLEDHYRSTFFFIHPSPINPQSNLSIDHRSPKPNHIPVPLRKKLKNWVTQMAGQLEHDPNLEVLLETLLPSSSSKSATTASSTSIARQTQERIVVMDLASVPIINGFDYYRSRVDDEYEIQEDRNRINNQSLKRGTENQPKINNKQQQQQSKVIKEDGVDQRPYLIKKFTKSPASIIVKINEGKQKITFSLISQLFKYWIKLGFEPVSGQRDFILSIIFPRPPTSCSSSTTFKYSQSKRKSNDHSSDNLMDDHNSVKIHKKQQGLLHLNLLSVHQWLLELAHTYKSCRLGELTIGKIHESKYRAGDIKKEIEGMIGEIEGSKRRGRHTCLIIVDRIEEMKSLGVGESEIVGIDGRPVTRLLISRQQLLDDRPSSLISFGLRLYDSMKIFVHRFKAPGLSFDPNLSRSTQSRDEIECSDSDDCPEKLQQQPNQTDGRSQSKEEIQDKMDIDHPGVSNKQPTKLLSSHAFFLNGIQKPTQLNIRWPPSGIDVTTRHRILHLGYLVAPHRDWVLVSSIDELGQQHQLVLKFTAVDSTSKLMRNHHLQIVKTVWNVLKKIILATNVEWRIVITKLGRLKPVEYEAWCELLSETIPVSEIAFHVTLSSVMFRDIPILKRRVDTEDPSGLMKTSENEAGIIGGEGSDLEMGEVEVMEEGEEGTVKGGGGSNSSAPISKTEEESVAGVEKLFGGPEPIWVSHESTIRPHSSYADSRGSSHEDAEGRSINGTIVHSLSTSYIYHLHTPFHSAPTTGSTGHPGGQRFRFDILGTAATPASVYQANLFQHREEIIHSIVQLSKLKSLRTGFPPSTHSHSLSDNGDKEEEDGFNNGNVDLLLPVHLNSLRIIGNQLVRNWTRLSQLFSTNEDDDEEEDDDSINPTPVDQSGILNQTPREVGNLDGTVADDGGDGDDDGDGEIDADGVADISDLEDEDTEL
Length2363
PositionKinase
OrganismPuccinia striiformis f. sp. tritici PST-78
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Pucciniomycotina> Pucciniomycetes> Pucciniales> Pucciniaceae> Puccinia.
Aromaticity0.06
Grand average of hydropathy-0.716
Instability index57.86
Isoelectric point6.33
Molecular weight261896.85
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
chromatin binding	GO:0003682	IEA:InterPro
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
cell cycle	GO:0007049	IEA:UniProtKB-KW
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP04604
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             7|     290.18|      32|      32|      32|      63|       1
---------------------------------------------------------------------------
   32-   63 (65.77/31.94)	QQQL......QQ.QQYQQNYHHQ...QQQ......LQQQQ..........H..................HHH...QQQQ
   65-   87 (33.92/12.24)	Q............QQFQ.NQHHQflfQQQ.......QQQQ..........H..........................IQ
   89-  120 (40.09/16.05)	QPQLlhrhphQL.QQAHSLLHHP.............HHHP..........H..................HHH...HQ..
  121-  159 (43.34/18.07)	QHNL......QQ.QAYQQNTHHP............LPSSSsssssaaalaN..................SNH...TPRQ
  165-  202 (33.48/11.97)	QPNL......HQ.RQLQKN...Q...QAQpstspiLSRAN..........H..................QSPsyvRSQS
  224-  256 (45.42/19.35)	PPLA......QQpQRLHQQHHHN...KFT......SDSRS..........N..................QHH...RDPS
  261-  306 (28.16/ 8.68)	NRQS......SL.RTNLALPHH.....PS......LPKPP..........HsdrtptipihppptstqaHHH...TQ..
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      69.50|      22|      32|    1111|    1142|       2
---------------------------------------------------------------------------
 1111- 1135 (34.55/16.92)	GSTASTI.SYNTNlfeQP.TPGSLSIS
 1144- 1167 (34.95/19.09)	GSTPDTAhHFNNN...HPsTQPALYSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      85.05|      25|      27|    1832|    1857|       3
---------------------------------------------------------------------------
 1832- 1857 (43.12/33.81)	LSFDPNLS..RStQSRDEIECSDSDDCP
 1860- 1886 (41.92/27.40)	LQQQPNQTdgRS.QSKEEIQDKMDIDHP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     120.27|      31|      32|    1344|    1374|       4
---------------------------------------------------------------------------
 1326- 1351 (36.39/14.84)	..PLTS....SAIGSTTQGATGYGESPATPRS
 1352- 1382 (58.08/28.36)	WVPIGS.PNDSSDGSNCSDDEDEQDGNGFNRT
 1385- 1408 (25.80/ 8.24)	AHDYGScSSSTSTTSSSSDDEDDR........
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.38|      14|      17|     696|     710|       5
---------------------------------------------------------------------------
  696-  710 (22.91/13.53)	PSFTArRLAPMPSLQ
  716-  729 (28.47/13.04)	PGFPL.ILAPFPNLR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.93|      15|      17|     514|     529|       6
---------------------------------------------------------------------------
  285-  300 (23.93/10.92)	DRTPTIpIHPPPTSTQ
  514-  528 (28.00/ 9.11)	DQPPPL.IDPKSKSYQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     145.60|      33|      34|     795|     827|       7
---------------------------------------------------------------------------
  795-  827 (63.91/33.64)	KQTWRMAAPFLEAHPDAHPTSTTD.VHP.....R.RLENW
  831-  864 (39.62/18.00)	KITTSGAAP.....PKNNQNSEIElVWPvdhclL.DLETW
  869-  900 (42.07/19.58)	EQNTTPATESDQAATLMTPLSGIC.L.P.....RaRLAN.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.35|      13|      16|    1946|    1958|       9
---------------------------------------------------------------------------
 1946- 1958 (22.16/12.33)	VSSIDELGQQHQL
 1965- 1977 (21.19/11.43)	VDSTSKLMRNHHL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      89.01|      26|      36|    2288|    2315|      10
---------------------------------------------------------------------------
 2288- 2315 (42.37/36.47)	QLFSTNEDDDEEEDDDsiNPTPVDQSGI
 2325- 2350 (46.64/33.03)	NLDGTVADDGGDGDDD..GDGEIDADGV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      92.90|      31|      38|     356|     391|      12
---------------------------------------------------------------------------
  355-  389 (51.63/30.84)	APEEQHGLGG...PQSA.........GYFSSSAAELNPWRAcspcKW
  391-  433 (41.28/18.51)	VPLVESGLPSvptPSDTlsideevdeTNCLSSNVEEDEWKI....RW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.35|      18|      38|     988|    1006|      15
---------------------------------------------------------------------------
  988- 1006 (28.82/22.70)	PVPSHLItPRLSKKRSRDD
 1029- 1046 (33.53/21.43)	PFGSGII.PRNATASGQDD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     129.62|      33|      37|    1209|    1241|      17
---------------------------------------------------------------------------
 1171- 1198 (28.23/15.93)	.......SDRLLTSTEqPAGP.....SHvDQLAVSEHALR
 1209- 1241 (59.27/45.06)	G.....PSAQLFRVVE.PVGYESVRFSH.AHTVVDEHYTR
 1244- 1276 (42.12/28.98)	GkyalpPSPHSFS......GQEDEQDDN.MMEIVDQELFR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      79.07|      22|      27|     530|     551|      18
---------------------------------------------------------------------------
  530-  551 (39.23/25.52)	FENQTAISDPSPIKACQSVISH
  560-  581 (39.84/26.08)	FPNVFSRSTTSNTKPLLPHLSH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.26|      13|      20|     470|     482|      21
---------------------------------------------------------------------------
  470-  482 (22.19/11.08)	FVFDSEEEAGAHR
  492-  504 (25.07/13.47)	WVYEIPGRLGPKR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     108.69|      34|      37|    2135|    2170|      22
---------------------------------------------------------------------------
 2135- 2170 (51.27/36.52)	PHSSyADSRGSSHEDAeGRSINGTIVHSLST.SYIYH
 2174- 2208 (57.42/31.72)	PFHS.APTTGSTGHPG.GQRFRFDILGTAATpASVYQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.05|      15|      21|    2085|    2104|      26
---------------------------------------------------------------------------
 2085- 2099 (26.25/ 8.37)	EEGEEGTVKGGGGSN
 2109- 2123 (24.80/15.13)	EESVAGVEKLFGGPE
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP04604 with Med13 domain of Kingdom Fungi
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