<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP04603

Description Uncharacterized protein
SequenceMPHPQSLIKPNQTEQTGTSTNENGCLTVYQLKPPEWRLPTQLNRPELGHPGLHPAHIGQHEDASTKSLVQWGFSAQMLVSTESFSAHQMIYKKITDEAGFNVSSAALSALIEARRRFCAISSYDTKSTIKVPGRVTLNEQKRENWLRELADDSVPLLKLSKNVPHGFKGEKLLEMLVSRKIDCSRATWYIRLIGLNEINAQRNKNELSHIRYTLSFTSELCQFLQKQLAEVTVPLQMNLSSSTTSLITTSSRLAAMNVRSKPRSSTLSDPETRKHWVAKWNQSRMLLKRLYFESLLDQPTFFKWIIDQIKVANLAQINFLLEIHHSVLDRFNLSSNLVRGFVEACLLQIRFITKQTGTSYLSKLERRLKLAVQSAFIFCPDNFVWPELWISNKLLLEEIILTPIISTNNNSSEHNAQTHHLKEMFKGDFHAVNWRVSELIGEVGNGTGIVENIFTRRAQLVEILDSYTDYNDCSRLYYKYFLNPSVAGHIPVSFKDKLEVLLSWATTPLRNSDKRVQLVASTLSHVKHDYKKNGDEFQNILVGWLEQVESIEGGDLLVRLFSELSRRNIFSCGAYVQRMVAKGDTECDIIAGKASGLQALLSEWMPLASSKSARERSSFIKRSPGRDCARNGLMAIVADLNSAIASADYGRFASLLKRRLDVCQPTSANRKLLAEILPNALVNLISELAFPSVMGSSFLVSKTINHPQLASALLTWGIRLLEACQAYTTLIEIMQRIVQLDLSRLESLRSEARTDLNSSLQSTLSYLQVICLAASNNKEILEINGQLIDFISRLFTIYVHSRRLIMGSSPVLRGFVRCLRSLVIESNAVDRQISEVLDKEYHPIVDELMTGPSTGETLPSRTREILQIIECPSTEQASQLVLKYWEDYRSDMDWGPVLWNSLIAAIKIYSQEELDEPLTKANSDNVHISNENWGQFREVVMQFCEDLDMLYEEGLMGCIRPEGYIHYPHPDDESLFSQSVHTSDSKMTPEEEEGEESEEISMEGPSLKSLFFHNPRSLCRNIRRLLVELMSCGLISIEVGLEEYIRPLADDVPQLLVNLCGDHSSETLRASQSTQAEEALRQVKEISELVKEALCEQHNDRCPLGSQSPEKESAAMMTPSQSRSGGNMSFTNHGSSEISFKSKEVVEYALEEFVRAWRLNVERKLWFEQSDEGAAFCSRLLLSLLISIKTISEVSLDYHEAPENPTIGQQKQLVEGLITEILGVFESLRVSVCRDSTLLHRQIPAHAAVFLDPILEFVHKNDLGTTFHTKLIHSIDQLLPYSQATESVTQKYPHLESIFKATCIFNHAARARQFQLHIRLLMSHNPSQMSTITEAPIDVTGTLGTLVEVMAKRLHLTDSKDASPFFLDYLPAQVAEALIIKLSLYLGMSICKLLGPNNTDSALEILRIHHICRCITILTNQLTIRKYQPNDDITSKVIGGSGPLGCNATVESYMSYWQQLKSGLSLFNTRLQASNTTPLSPKRTEYQIMRALLHSIQAVLWSLPGLTQQLGTLKQTIAEIWIEIALRVQGDSALQNQIIDTISVLLFPTVPDDSCLTATVGILRKRFRWLYLPILNMDDGTNLVPTNRLKYLLGSSLRGSSTIFQERLTDGAVKFVEEKPWEELEKMDLSGPGFISIDALKCQTLSHIEHIPEPRRLVMSSKRKSKSRRESKAEGEEAMADEKEAGGERGFDQPKMGGGQQQLASEEEDGEDDDEGLERGERNCFEHELITDGLSTMPLHFLRSLFPPATRLSGEDWLAAQEQQKALQTQQAEQARVQQQQQQQSSNEIGGEQDSSRIKKRKALGLSPSSVEPSLPSSTTGPTLRSARSTRKKSSAAAPVPPAPTTSGSKRAKKR
Length1855
PositionKinase
OrganismPuccinia striiformis f. sp. tritici PST-78
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Pucciniomycotina> Pucciniomycetes> Pucciniales> Pucciniaceae> Puccinia.
Aromaticity0.07
Grand average of hydropathy-0.291
Instability index56.06
Isoelectric point6.22
Molecular weight208615.61
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP04603
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     130.32|      39|      84|    1681|    1719|       1
---------------------------------------------------------------------------
 1681- 1719 (66.72/43.06)	DEKEAGGERGFDQPKMGGGQQQLASEEEDGEDDDEGLER
 1762- 1800 (63.60/40.69)	EQQKALQTQQAEQARVQQQQQQQSSNEIGGEQDSSRIKK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     130.58|      38|      84|     775|     812|       2
---------------------------------------------------------------------------
  775-  812 (64.89/39.92)	SNNKEILE.INGQLIDFISRLFTIYVHSRRLIMGSSPVL
  860-  898 (65.69/40.51)	SRTREILQiIECPSTEQASQLVLKYWEDYRSDMDWGPVL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     442.82|     148|     173|    1179|    1351|       3
---------------------------------------------------------------------------
 1179- 1351 (205.93/206.88)	RLLLSlliSIKTISEVSLDYHEApenptigqqkQLVEGL...........ITEILG......VFESLRV.SVCRDSTLLHRQIPAHAAVFLDPILEFVhkndLGTTFHTKLIHSIDQLLPYSQATESVTQKYphlESIFKATCIFNHAARARQFQLhIRLLMsHnpSQMSTITEAPiDVTGTLGTLVEVMA
 1353- 1518 (236.89/163.12)	RLHLT...DSKDASPFFLDYLPA..........QVAEALiiklslylgmsICKLLGpnntdsALEILRIhHICRCITILTNQLTIRKYQPNDDITSKV....IGGSGPLGCNATVESYMSYWQQLKSGLSLF...NTRLQASNTTPLSPKRTEYQI.MRALL.H..SIQAVLWSLP.GLTQQLGTLKQTIA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     109.19|      32|     173|     144|     175|       4
---------------------------------------------------------------------------
  144-  175 (57.50/33.68)	NWLRELADDSVPLLKLSKNVPHGFKGEKLLEM
  318-  349 (51.69/29.55)	NFLLEIHHSVLDRFNLSSNLVRGFVEACLLQI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     293.46|     101|     281|     360|     478|       6
---------------------------------------------------------------------------
  360-  478 (154.26/148.40)	YLSKLERRLKLavqsafifC.PDNfvwpelwiSNKLLLEEII...LTPIISTNNNSSEHNAQTHHLKEMFKGDFHA..VNWRVsELIGEVGNGTGIVEnIFTRRAQL....VEIL..DSYTDYNDC..SRLYY
  652-  766 (139.20/93.47)	FASLLKRRLDV........CqPTS........ANRKLLAEILpnaLVNLISELAFPSVMGSSFLVSKTINHPQLASalLTWGI.RLLEACQAYTTLIE.IMQRIVQLdlsrLESLrsEARTDLNSSlqSTLSY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     105.26|      35|      84|     981|    1019|       7
---------------------------------------------------------------------------
  981- 1019 (54.40/45.85)	HTSD....SKMTPEEEEGEESEEIS.MEGPSLKSLffHNPRslC
 1063- 1102 (50.86/30.16)	HSSEtlraSQSTQAEEALRQVKEISeLVKEALCEQ..HNDR..C
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      40.89|      11|    1119|     518|     528|       8
---------------------------------------------------------------------------
  518-  528 (19.33/10.72)	LVASTLSHVKH
 1640- 1650 (21.56/12.80)	LKCQTLSHIEH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      76.71|      22|      77|     950|     972|      11
---------------------------------------------------------------------------
  950-  972 (41.10/33.47)	LYEEGLMGC.IRPEGYIHyPHPDD
 1029- 1051 (35.61/22.65)	LMSCGLISIeVGLEEYIR.PLADD
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP04603 with Med12 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) EPRRLVMSSKRKSKSRRESKAEGEEAMADEKEAGGERGFDQPKMGGGQQQLASEEEDGEDDDEGLERGERNCFEHELIT
2) FSQSVHTSDSKMTPEEEEGEESEEISMEGP
3) TRLSGEDWLAAQEQQKALQTQQAEQARVQQQQQQQSSNEIGGEQDSSRIKKRKALGLSPSSVEPSLPSSTTGPTLRSARSTRKKSSAAAPVPPAPTTSGSKRAKKR
1653
976
1750
1731
1005
1855










Molecular Recognition Features






MoRF SequenceStartStop




1) RIKKRKALGLS
2) SGSKRAKKR
3) TRKKSSA
1797
1847
1830
1807
1855
1836