<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP04598

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMTDGAAISTPLAQPPPLTGMRRFDPHGSLPQHHGDMIPLAAVVRRVTHHAMASLRTTLSWKGLSPVQSDERKRALLDHIRQTRLLLTKLALITQWAHHSSAFVCAQSIVALLQADDAAFDATVFMLHAHADALNRARARNFDVVTAIDVLSSGHYRALPKIMKTSLIPEPLRDDEVAQTMAALNDMIRMRLVSMECGVPAELLRDCRIDMGRVIFTVAHEFELTMTLPGGPDPNGPWHILDFRILDPNLALHEYQRQNLVHIGNSKLLAASGAGATQVPPQPPPGSAAGSTAIVPAGPTVHFPLLEVYHFFHHFILTLRLEKLVDDGRTLELAYWSNSRNGATVRVALRETERRDVINISAHPVVQCPPEPTATPALVALPAKPATASFTYSGTSLVVQHLGRETPIVASTTLTALLAQCLDTHTARILAELATLVERGAVNDGMPGPPPPPAVPEAALVGDGSASPPEVKDCALHLPAYAVSIAVHRQSGRFHVAPLDRYNEKLQHLEAMLNEDPLFLPHTLANYATARLMDRIVTSVTFLGLVPSPRPPNALTVASSGSPATLGPRVFLRVVHKPAVPEYHLAVNVVQGVVTCWVLHWPSMTVVKEYHPSLHDLVETFDQYTSLHQIQAALTAKGVHLAWHGAGLAIDPLSFPPGAGLLLAVETLTVVPLETPPQVRVQCRLKYALPGLGATTVLAFKAKSVRTALRRCLVALGITHLLVQSDPRDVLDMDLDAGNVRYRIGAAREMLVQVQMAAAAAPSAVTAASAGESGSRALVKAGTSQSTRSDPLSSAPPTVTKVVGWTDAPYSFRVTMGTDAIFDPIARAAQAYLNQRGHVDLCLPSLCLAVHIWTVVAHRLNVHRTQTSRAYPRLVVKSANFATIYLTRTAALHLRYLLDETRRCLVVSARHFPLFASLSRAVTTRVTSHAGLHAVALPNAIILPASDARAAAVDAMLDALLDQYTRTCVLLDAHAALVARFPAGRPTSASAAAAAAAAEANQPRVMQYAPPAPTAGRGRRRRRGAVLVWCDVAVRVTATAVHADADAVPSAAAAATGNGAAPPPLSVDTTRQLGVHERRALARLLQFDFAHGLAAAGVPPLAVPAALPASDPSALMTNVVDALMTLMALPVPVIRAIAQCSALVADTSPPRHVALLFLAPPKGAVPHDVQRCLPPPSRPCLLVSRAAPARVEPADGARTGAPGAPGTPGPTATGGGGNDEDSVSLVFVLTCPPVPASAPPPPPPIYVPVTYAWSSNVVSPWEGLPVSAAARGGAMNPTELLAFLNAKGGMAAAVTRRRNVADVVNDLKREGFAVAQQENLLVWTMRRVVARHVAELA
Length1336
PositionTail
OrganismAllomyces macrogynus (strain ATCC 38327) (Allomyces javanicus var. macrogynus)
KingdomFungi
LineageEukaryota> Fungi> Fungi incertae sedis> Blastocladiomycota> Blastocladiomycota incertae sedis> Blastocladiomycetes> Blastocladiales> Blastocladiaceae> Allomyces.
Aromaticity0.05
Grand average of hydropathy0.139
Instability index41.14
Isoelectric point9.10
Molecular weight142062.43
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP04598
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|    1014.62|     259|     266|      45|     310|       1
---------------------------------------------------------------------------
   12-  279 (393.44/175.05)	AQPPP..LTGMRRFDPHGslPQHHgdmIPLAAV.....vrRVTHHA...M.....ASLR........TTLSWKGLSP..VQSDERKR.......ALLD......HIRQT..RLLL.TKLA.LITQWAH.HSSAfVCAQSIVALLQADDA.............................AFDATVFMLHAHADALNRARARNFDVV.....TAI..DVLS........SGHYRALPKImkTSLIP....EPLRDDEVAQTMAAlNDMIRMRLVSMECGVPAEL...LRDCRIDMGRVIFTVA.HEFELTMTLPGGPDPNGPW........HILDFRILDPNLAL.....HEYQRqNLVHIGNSKLLAASGAGAT...QVP
  280-  546 (320.06/134.82)	PQPPPgsAAGSTAIVPAG..PTVH...FPLLEVYHF..............fhhfiLTLRleklvddgRTLEL....A..YWSNSRNG.......ATVR.....vALRETerRDVI.NISAhPVVQCPP.EPTA...TPALVAL.....P.............................AKPATASFTYSGTSLVVQHLGRETPIVasttlTALlaQCLD........THTARILAEL..ATLVE....RGAVNDGMPGPPPP.PAVPEAALVGDGSASPPE....VKDCALHLPAYAVSIAvHR.......QSGRFHVAPLdryneklqHLEAMLNEDPLFLP.....H.....TLANYATARLMDRIVTSVTflgLVP
  707-  793 (38.55/ 8.13)	........................................................ALR........RCLVALGITHllVQSDPRD.........VLDmdldagNVRY...RIGA.AREM.LV.QVQM.AAAA...APSAVTAASAGES.............................GSRA...LVKAGTS...QS.............TRS..DPLS........S.......................................................................................................................................................
  910- 1190 (262.57/105.99)	.......................H...FPLFASLSRavttRVTSHAglhA.....VALP........NAIIL....P...ASDARAAavdamldALLD......QYTRT..CVLLdAHAA.LVARFPAgRPTS.ASAAAAAAAAEANQPrvmqyappaptagrgrrrrrgavlvwcdvAVRVTATAVHADADAVPSAAAAATGNG.....AAP..PPLSvdttrqlgVHERRALAR.....LLQfdfaHGLAAAGV....PP.LAVPAALPASD....PSALmtnVVDALMTLMALPVPVI.RAIAQCSALVADTSP..PR........HV.ALLFLAP...PkgavpHDVQR.CLPPPSRPCLLVSRAAPA....RV.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.34|      15|      15|    1247|    1261|       2
---------------------------------------------------------------------------
 1247- 1261 (29.75/20.29)	PVTYAWSSNVVSPWE
 1264- 1278 (26.59/17.16)	PVSAAARGGAMNPTE
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP04598 with Med14 domain of Kingdom Fungi
Unable to open file!