<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP04597

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMKTSFIPEPLRDDEVAQTMAALNDMIRMRLVSMECGVPAELLRDCRVDMGRVIFTVAHEFELTLTLPGGPDPNGPWHILDFRILDPNLALHEYQRQNLVHIGNSKLLAASGAGAAQVPPQPPPGAAAGSTAVVSAGPTVHFPLLEVYHFFHHFILTLRLEKMVVESYTLLNSPNAPGLDTISVKDDGRTLELAYWSNSRNGATVRVSLRETERRDVINISAHPVVQCPPEPTATPALVALPVRPTTASFTYSATSLVVQHLGRESPIVESKTLTALLAQCLDTHTARILTELATLVERGAVNDGMPGPPPPPAVPEAALVGGSSASPPHVSDGALHLPVYAVSIAVHRQSGKFHVAPLDRYNEKLQHLEAMLNEDPLFLPHTLANYATARLMDRIVTSVTFLGLVPSPRPPNALTVASSGQAANLGPRVFLRVVHKPAVPEYHLAVNVVQGVVTCWVLHWPSMTVVKEYHPSLHDLVETFDQYTSLHQIQAALAVKGVHLAWHGAGLAIDPLSFPPGAGLLLAVETLTVVPLETPPQVHVQCRLKYALPGLGATTVLAFKAKSVRTALRRCVVALGIVHLLVQSDPRDVIDVDLDAGSMRYRIGAAREMLVQVQMAAAGPVSSAGPSSGENGRAMITAGTSPSTRTDLSPSVAKVVGWTEAPYSFRVTMGADAIFDPIARAAQANLNQHGHVDLCLPSLCLAVHVWTIVASRLHAHRTQTSRAYPRFVVKSAEFATVYLTRTAALHLRYLLDETRRCLVVSSRHFPLFASLSRAVTTRVTSHAGLQAVALPNAIILPASDARAAAVEAMLDALLDQYTRTRVLLDAHAALIARFPPGRPTSASAAAAAAAVEANQPRVMQYAPPPPPRDVVVDDDAVRFIWCDVAVRVTATAVHADADAVPAAAAAAAAGAGGNGAPPSLSVDTTRQLGVHERRALARLLQFDFAHGLAAAGVTPPSAAPAAPTSDPGALMANVVDALMTLMALPVPVIRAIAQCSALVAETNPPRHVALLFLAPPKGAVPHDVQRCLPPPSRPCLLVSRAAPARSLESADGANSGAPGAPGTPGPTATSGGGGNDEDSVSLVFVLTCPPVPVGAPPPPPPIYVPVTYAWSSNVVSPWEGLPVSAAGSGKEMNPSMLLAILAGQGGMPTAATRRRTVADVVNDLKREGFAVAQQENLLVWTMRRVVARHVAELA
Length1194
PositionTail
OrganismAllomyces macrogynus (strain ATCC 38327) (Allomyces javanicus var. macrogynus)
KingdomFungi
LineageEukaryota> Fungi> Fungi incertae sedis> Blastocladiomycota> Blastocladiomycota incertae sedis> Blastocladiomycetes> Blastocladiales> Blastocladiaceae> Allomyces.
Aromaticity0.05
Grand average of hydropathy0.155
Instability index40.18
Isoelectric point7.14
Molecular weight126256.89
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP04597
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     664.26|     205|     231|     131|     361|       1
---------------------------------------------------------------------------
   63-  295 (285.96/200.38)	TLTLPGGPDPNGPWHILDFRILDPNLALHEYQRQNLVHIG..NSKLLAASGAGAAQVPPQPPP.gaaagstAVVSAGPtVHFPllevyHFFHHFIlTLRLEKMVVESYTLLN...SPNAPglDTISVKDDGRTLELAywsnSRngATVRVSLRET..ERRDVINIsAHPVVQC..PPEPTAT......PALV...ALPVRPTTASF.TYSA.....TSLVVQ..HLGRESPiveskTLTALLAQCLDTHT....ARILTELATL
  299-  527 (274.17/148.42)	GAVNDGMPGPPPPPAVPEAALVGGSSASPPHVSDGALHLPvyAVSIAVHRQSGKFHVAPLDRYneklqhleAMLNEDP.LFLP.....HTLANYA.TARLMDRIVTSVTFLGlvpSPRPP..NALTVASSGQAANLG....PR..VFLRVVHKPAvpEYHLAVNV.VQGVVTCwvLHWPSMTvvkeyhPSLH...DL.....VETFdQYTSlhqiqAALAVKgvHLAWHG.........AGLA..IDPLSfppgAGLLLAVETL
 1013- 1088 (104.14/49.26)	........LAPPKGAVP......................................................................................................................................................HDVQRC..LPPPS.R......PCLLvsrAAPARSLESA...DGA.....NSGAPG..APGTPGP.....TATSG.GGGNDEDS....VSLVFVLTC.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     421.51|      96|     231|     856|     951|       2
---------------------------------------------------------------------------
  586-  663 (89.52/31.28)	PRDVIdVDLDAgsMRYRIG.....AAREMLVQ.VQMAA...AG..PVSSAGPSSGENGRamitaG....TSPSTRTDLSPS.................................................vAKVVGWTEAPY
  664-  754 (65.57/21.22)	........................SFRV..T..MGADAifDPI.....ARAAQANLNQH.....GhvdlCLPSLC......LAVH....VWTIVASRLH...AHRTQTSrayprfvvksaefatvyltrtaALHLRYLLDET
  755-  866 (116.43/42.59)	RRCLV.VSSRH..FPLFASlsrAVTTRVTSHAgLQAVAlpNAIilPASDARAAAVEAML.....D....ALLDQYTRTRVLLDAHaaliARFPPGRPTSASAAAAAAA..................veanqPRVMQYAPPPP
  867-  963 (149.99/56.70)	PRDVV.VDDDA..VRFIWC...DVAVRVTATA.VHADA..DAV..PAAAAAAAAGAGGN.....G....APPSLSVDTTRQLGVH....ERRALARLLQFDFAHGLAAA..................gvtpPSA...APAAP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP04597 with Med14 domain of Kingdom Fungi
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