<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP04595

Description Mediator of RNA polymerase II transcription subunit 5
SequenceMDGSTQDPRGALRESTAYWSNFIARCISKRLDTDRFEEFVPLVYSQHPLAPIFIADLFLKPQPTNDVSLDPRMPPYIKVLSRLGYIDAPSILWTMYKYSSLHAQLRLSQNGDNKEENQTRCRRISSWAEEVMFYHVIKTVVEGSSFRDSRAALVLVKSICKWMDLFTSASTAFAADVLGQIQSSQVRDEMDVARAAFIPLLLRLVETPSLIKVISKPVAKAVRKELSESLSGFIHTLQPSPGFVERLEIFRSETLARLDPVDKKKQAADNAAMDELLETTVGLENFVIPDIPISTTRAGLYVYLNASLVGRPLIDDNALLSYLHNRYQGETQSSAIDLVLASFDILANTVFRNEGQKDAHLLRSFLINKVPLLLCQLCSPQFSTTSSEFCITEALNQVDTSVFPTASLMFDESRSNNPYTESVREEFCTACALHGLVQREHVERILGETSMSYEPSLEKYSKDKLVQDCLSDPEKIQGLVRELDKMDGNVGAVSQALVELMRQLCNNKETMSLKLLCGQLAQKPQSLDILLLFEKLPAILEPLCQLLDNWRYDDDQGEYQPIYEEFGAILLLVLAFAYRYSLTGADIGITSTDSCITKILNRAHMSREMDELTMQEKGYINGWIHGLFDSEAGGLGDDLMSSCPPQDFYLLVASIFQNIVVAYTYGYLNDETLKSGIEYLVDTFLLPSLVPAIRFLADYLWVEQKEQKSIIKILQLILLPSSISGEASTMLSSVKNLIAKPLEHSLRTYQKQDPKNQDIEPLLRALKDSLPLSRRTGGAEHNELESWASSSSTGLAGAVKHTVQGLVQWSMHHGINVMPTSYTHRQMIAACRIMGTGRVLRVMLEEIRHQSEAGSANIVYDVVAALICAPDVTNEPPAAGNLLDAAGNVPPTLQRRLKLREVLRSDAQDCRKLQKKDAALAEIVVRLHRRVEAQMVLPQPQAMLEASDMPLDLSGGAAGLGDAMAAAAGVQGDGMSVEGVGLDMGLGGVSSDLGLGGPSGSVGGLDSTSDGDLFGGIDTSMDMFNGWDGMDLGGN
Length1035
PositionTail
OrganismTolypocladium ophioglossoides CBS 100239
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Ophiocordycipitaceae> Tolypocladium.
Aromaticity0.07
Grand average of hydropathy-0.093
Instability index43.73
Isoelectric point5.02
Molecular weight114153.23
Publications
PubMed=26215153

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364142
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP04595
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     117.71|      35|      36|     959|     994|       1
---------------------------------------------------------------------------
  959-  993 (62.10/36.06)	GLGDAMAAAAGVQ..GDGMSVEGV..GLDMGLGGVSSDL
  994- 1032 (55.61/36.16)	GLGGPSGSVGGLDstSDGDLFGGIdtSMDMFNGWDGMDL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.34|      16|      37|     380|     395|       2
---------------------------------------------------------------------------
  380-  395 (30.28/19.60)	PQFSTTS.................SEFCITEAL
  401-  433 (20.06/10.62)	SVFPTASlmfdesrsnnpytesvrEEFCTACAL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     117.01|      30|      31|     659|     688|       3
---------------------------------------------------------------------------
  633-  665 (44.07/24.09)	GGL..GDDLMSSCPPqdfYLLVASIFQNIVVAYTY
  666-  695 (50.92/28.87)	GYL..NDETLKSGIE...YLVDTFLLPSLVPAIRF
  698-  721 (22.02/ 8.74)	DYLwvEQKEQKSIIK...IL.QLILLPS.......
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.75|      14|      15|     503|     516|       4
---------------------------------------------------------------------------
  503-  516 (23.65/14.34)	QLCNNKETMSLKLL
  519-  532 (22.10/12.91)	QLAQKPQSLDILLL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.93|      14|      41|     141|     154|       5
---------------------------------------------------------------------------
  141-  154 (23.64/15.51)	VEGSSFRD....SRAALV
  181-  198 (18.29/10.31)	IQSSQVRDemdvARAAFI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.07|      16|      19|     769|     787|       6
---------------------------------------------------------------------------
  769-  787 (26.47/26.38)	SlplSRRTG..GA.EH..NELESW
  789-  809 (17.60/ 8.28)	S...SSSTGlaGAvKHtvQGLVQW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.09|      16|      18|     817|     832|       7
---------------------------------------------------------------------------
  811-  826 (30.72/24.83)	MHHGINVMPTSYTHRQ
  827-  842 (27.38/21.20)	MIAACRIMGTGRVLRV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     138.98|      35|     398|     468|     502|       8
---------------------------------------------------------------------------
  468-  502 (58.43/46.37)	DCLSDPEKIQGL....VRELDKMDGN.VGAVSQ...ALVELMR
  871-  904 (44.98/33.61)	DVTNEPPAAGNL.......LDAA.GN.VPPTLQrrlKLREVLR
  909-  945 (35.57/24.68)	DCRKLQKKDAALaeivVRLHRRVEAQmVLPQPQ...AMLE...
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.49|      13|      18|     735|     747|       9
---------------------------------------------------------------------------
  735-  747 (21.88/15.74)	KNLIAKPLEHSLR
  755-  767 (21.61/15.44)	KNQDIEPLLRALK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.42|      18|      27|     533|     552|      13
---------------------------------------------------------------------------
  533-  552 (30.29/24.83)	FEKLPAILepLCQLLDNWRY
  563-  580 (32.12/18.95)	YEEFGAIL..LLVLAFAYRY
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP04595 with Med5 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




NANANA









Molecular Recognition Features






MoRF SequenceStartStop




1) FNGWDGMDL
1024
1032