<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP04595

Description Mediator of RNA polymerase II transcription subunit 5
SequenceMDGSTQDPRGALRESTAYWSNFIARCISKRLDTDRFEEFVPLVYSQHPLAPIFIADLFLKPQPTNDVSLDPRMPPYIKVLSRLGYIDAPSILWTMYKYSSLHAQLRLSQNGDNKEENQTRCRRISSWAEEVMFYHVIKTVVEGSSFRDSRAALVLVKSICKWMDLFTSASTAFAADVLGQIQSSQVRDEMDVARAAFIPLLLRLVETPSLIKVISKPVAKAVRKELSESLSGFIHTLQPSPGFVERLEIFRSETLARLDPVDKKKQAADNAAMDELLETTVGLENFVIPDIPISTTRAGLYVYLNASLVGRPLIDDNALLSYLHNRYQGETQSSAIDLVLASFDILANTVFRNEGQKDAHLLRSFLINKVPLLLCQLCSPQFSTTSSEFCITEALNQVDTSVFPTASLMFDESRSNNPYTESVREEFCTACALHGLVQREHVERILGETSMSYEPSLEKYSKDKLVQDCLSDPEKIQGLVRELDKMDGNVGAVSQALVELMRQLCNNKETMSLKLLCGQLAQKPQSLDILLLFEKLPAILEPLCQLLDNWRYDDDQGEYQPIYEEFGAILLLVLAFAYRYSLTGADIGITSTDSCITKILNRAHMSREMDELTMQEKGYINGWIHGLFDSEAGGLGDDLMSSCPPQDFYLLVASIFQNIVVAYTYGYLNDETLKSGIEYLVDTFLLPSLVPAIRFLADYLWVEQKEQKSIIKILQLILLPSSISGEASTMLSSVKNLIAKPLEHSLRTYQKQDPKNQDIEPLLRALKDSLPLSRRTGGAEHNELESWASSSSTGLAGAVKHTVQGLVQWSMHHGINVMPTSYTHRQMIAACRIMGTGRVLRVMLEEIRHQSEAGSANIVYDVVAALICAPDVTNEPPAAGNLLDAAGNVPPTLQRRLKLREVLRSDAQDCRKLQKKDAALAEIVVRLHRRVEAQMVLPQPQAMLEASDMPLDLSGGAAGLGDAMAAAAGVQGDGMSVEGVGLDMGLGGVSSDLGLGGPSGSVGGLDSTSDGDLFGGIDTSMDMFNGWDGMDLGGN
Length1035
PositionTail
OrganismTolypocladium ophioglossoides CBS 100239
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Ophiocordycipitaceae> Tolypocladium.
Aromaticity0.07
Grand average of hydropathy-0.093
Instability index43.73
Isoelectric point5.02
Molecular weight114153.23
Publications
PubMed=26215153

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP04595
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     117.71|      35|      36|     959|     994|       1
---------------------------------------------------------------------------
  959-  993 (62.10/36.06)	GLGDAMAAAAGVQ..GDGMSVEGV..GLDMGLGGVSSDL
  994- 1032 (55.61/36.16)	GLGGPSGSVGGLDstSDGDLFGGIdtSMDMFNGWDGMDL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.34|      16|      37|     380|     395|       2
---------------------------------------------------------------------------
  380-  395 (30.28/19.60)	PQFSTTS.................SEFCITEAL
  401-  433 (20.06/10.62)	SVFPTASlmfdesrsnnpytesvrEEFCTACAL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     117.01|      30|      31|     659|     688|       3
---------------------------------------------------------------------------
  633-  665 (44.07/24.09)	GGL..GDDLMSSCPPqdfYLLVASIFQNIVVAYTY
  666-  695 (50.92/28.87)	GYL..NDETLKSGIE...YLVDTFLLPSLVPAIRF
  698-  721 (22.02/ 8.74)	DYLwvEQKEQKSIIK...IL.QLILLPS.......
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.75|      14|      15|     503|     516|       4
---------------------------------------------------------------------------
  503-  516 (23.65/14.34)	QLCNNKETMSLKLL
  519-  532 (22.10/12.91)	QLAQKPQSLDILLL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.93|      14|      41|     141|     154|       5
---------------------------------------------------------------------------
  141-  154 (23.64/15.51)	VEGSSFRD....SRAALV
  181-  198 (18.29/10.31)	IQSSQVRDemdvARAAFI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.07|      16|      19|     769|     787|       6
---------------------------------------------------------------------------
  769-  787 (26.47/26.38)	SlplSRRTG..GA.EH..NELESW
  789-  809 (17.60/ 8.28)	S...SSSTGlaGAvKHtvQGLVQW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.09|      16|      18|     817|     832|       7
---------------------------------------------------------------------------
  811-  826 (30.72/24.83)	MHHGINVMPTSYTHRQ
  827-  842 (27.38/21.20)	MIAACRIMGTGRVLRV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     138.98|      35|     398|     468|     502|       8
---------------------------------------------------------------------------
  468-  502 (58.43/46.37)	DCLSDPEKIQGL....VRELDKMDGN.VGAVSQ...ALVELMR
  871-  904 (44.98/33.61)	DVTNEPPAAGNL.......LDAA.GN.VPPTLQrrlKLREVLR
  909-  945 (35.57/24.68)	DCRKLQKKDAALaeivVRLHRRVEAQmVLPQPQ...AMLE...
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.49|      13|      18|     735|     747|       9
---------------------------------------------------------------------------
  735-  747 (21.88/15.74)	KNLIAKPLEHSLR
  755-  767 (21.61/15.44)	KNQDIEPLLRALK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.42|      18|      27|     533|     552|      13
---------------------------------------------------------------------------
  533-  552 (30.29/24.83)	FEKLPAILepLCQLLDNWRY
  563-  580 (32.12/18.95)	YEEFGAIL..LLVLAFAYRY
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP04595 with Med5 domain of Kingdom Fungi
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