<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP04594

Description Mediator of RNA polymerase II transcription subunit 19 (Fragment)
SequenceNTATPPQRCNAASSLPQRAAAAAALTLPYIGTLRFRVSRRRRGGTTTSDLNMSLSASIASGTTLPTPAHSVNGGYSQPDVLMSDEPPHKRKRSLDDVGDRDQKKMHLEDRKLGIEDLHLDVGDKYLLCQTLHPQPLPRMSEDLFEMFGLTDLAAEVAREKPNGEKNALRKTYKGHIKRLGVAGHFDVQKKKEEEPSDFVAMVQVPELEWNVHQAKGREVGDGLSEAILSSLGRALTMSKGPIPKAIWDTSVLGDLAPANADASKPVSAKPTAPNTPLASTPNAMSRSKSLLPPGHDPTRPRRNIKKRSYGDSSFEGYGEGFPDDDAGLDTGYSTGEGEAGQKRRKKSSGNSPPYPTIRQQSYGPGMVGA
Length369
PositionHead
OrganismTolypocladium ophioglossoides CBS 100239
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Ophiocordycipitaceae> Tolypocladium.
Aromaticity0.05
Grand average of hydropathy-0.724
Instability index54.75
Isoelectric point9.21
Molecular weight39842.34
Publications
PubMed=26215153

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364151
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP04594
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.14|      16|      23|     227|     244|       1
---------------------------------------------------------------------------
  227-  242 (26.11/16.37)	ILSSLGRALTMSKGPI
  251-  266 (26.03/ 9.57)	VLGDLAPANADASKPV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      75.68|      22|      23|      96|     117|       2
---------------------------------------------------------------------------
   96-  117 (38.95/31.30)	DVGDRDQKKMHLEDRKLG..IEDL
  120-  143 (36.73/29.05)	DVGDKYLLCQTLHPQPLPrmSEDL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.86|      11|      29|      43|      53|       3
---------------------------------------------------------------------------
   43-   53 (20.31/10.48)	GGTTTSDLNMS
   73-   83 (21.55/11.49)	GGYSQPDVLMS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.35|      13|      23|     185|     197|       4
---------------------------------------------------------------------------
  185-  197 (22.15/16.15)	FDVQKKKEEEPSD
  209-  221 (24.21/18.34)	WNVHQAKGREVGD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      33.77|      10|      35|      19|      28|       5
---------------------------------------------------------------------------
   19-   28 (16.25/ 9.85)	AAAAAALTLP
   56-   65 (17.52/11.15)	ASIASGTTLP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP04594 with Med19 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) APANADASKPVSAKPTAPNTPLASTPNAMSRSKSLLPPGHDPTRPRRNIKKRSYGDSSFEGYGEGFPDDDAGLDTGYSTGEGEAGQKRRKKSSGNSPPYPTIRQQSYGPGMVGA
2) RRRGGTTTSDLNMSLSASIASGTTLPTPAHSVNGGYSQPDVLMSDEPPHKRKRSLDDVGDRDQKKMHLED
256
40
369
109










Molecular Recognition Features






MoRF SequenceStartStop




1) AGQKRRKKSS
2) ALTLPYI
3) SPPYPTIRQQSYGPGMVG
339
24
351
348
30
368