<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP04588
Description |
Mediator of RNA polymerase II transcription subunit 11 |
Sequence | MSTPDDVVMGQGDAPRAQQPFTVEENIHQLNAIDKSIVQLMNHAATALNALTTPATSSSANLSPDAAARKPALDPPAQKEAFRSATDSFLTTLHSVDVRMKRQVLALEEAGILNLSNAPRQDTNGAAKASLKPNGVGTVGGLDVGWLNSRSTGVERDMEAELWREAREFLEKHSEKIKLAERS |
Length | 183 |
Position | Head |
Organism | Tolypocladium ophioglossoides CBS 100239 |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes>
Hypocreomycetidae> Hypocreales> Ophiocordycipitaceae> Tolypocladium.
|
Aromaticity | 0.03 |
Grand average of hydropathy | -0.458 |
Instability index | 39.61 |
Isoelectric point | 5.59 |
Molecular weight | 19696.85 |
Publications | PubMed=26215153
|
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364147
|
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP04588
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 106.25| 34| 57| 41| 75| 1
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41- 75 (51.33/32.65) MNHAATALNALTTPATSSSANLSPDAAArKPALDP
100- 133 (54.92/30.85) MKRQVLALEEAGILNLSNAPRQDTNGAA.KASLKP
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