<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP04587

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMDTAEYDTNTLLINNIASIAFRVYESPSDLPQSFASVALDIENTLREEGHVVFYDAARRGIWHFRIIGKQGHDDVTSHGIDATLELCGQTLVVGEEGALEPASLQRTRPQQQQQQGIQTPTSSISSASALDQSQRNAFASASQGAVPSSQDHDAKTADASGVDSKAGATPNKTVYENFVTAVLLSISSTFCNRSGAVPLNFRTVLLPPEPLESGDPRDADAEQCPVLATLKAYLTTTGALVISFGVSRCKGLTSVVDLVATSPALPGTPILAAPFGVVALNQFSSAVEAGTPSLAQTPNTQALSLRGGPDVHDSLWKQACLKILKLRGVASTSLSDCSWVSLLVSKPKLQGAYNETRRVQALGSGISIPWPGPLCFRKRAVEVSSTSRVGDTLLSGHEESHDPLGRARAWFNTATERDEKVLKRKAERAAASKDASSAESRVPKPSAPSPVAIRRPSTAAASAIYPTPPDGIQHPNGVTPSFDGTLSSPGNPLSVAPATETDPAAPSTIAMGDTFDVEGDFSESKRQRSESNLLGEAEHVFGVMGEDMFGDNDITEADFNFFDEQQPGDSDADMSMDDAGAANNASDEAPKADEESLRVANEAKPEPVPQRDAMVFAKPELKHARSSRNDAVGQRGRDTPSGATKRESSPFDPHTVFKRVRASLVATERGSSIPLPDSTRMTRIFESMSFDSTLPMINKKYEQGGQFDYKKIARTEKPRLEPGMLPETDYLKRHGRQGRRLKDRRLHAGSLVRTLTGIVPPTLHPSPTKVEGSLSDDDDSSVGSDQDDSSYTTEEPTSPLKSSVKLVALDDDATSQITSLREVEPLEEPNQHLAMELPRLSKPEIPELPLALLFSDPEPLSLDLSLSDDDLVQVAQILTEQAALGSLDICNAQEGISPHPDTNLSCQSLSVDARNAIRILRDFVPSLLRGAGGINLKGFLDIPDIPLLGQPSRLQPRPIPGRDPNVEPLRPSNLYQISGPHLEVRRYEVKLSVLPSAVPFWESLGLAPSPGGKDINAICVFPGWNGMVDNVKTFLGRVKSVYEMLKLGSLESMPSSADMDDGILPYEVDRISTSPDATMTGHGSALIEIMETLRGAISNLTVTETNVVVYFVYSPNNPGTMVEACIAFQRFFDSYRKALASQREAAPNELVLQLVSADMLSSATTVVVTPVPELIKLCMETYDRCTLFGGPMPAPAIRLEQPLPRIIDFKLTMSPSASLIRENSCIHVAYAPSVDGRWVTAAWTDDRGSQQETASYCLGRKGRPQSRTMNEVAHEIWESTLDLISVWKVHWRIIITKCGPMDQQEVDFWVDLARTEIKASVTMILMTVDTNPSLQLIPPVVKLPQPSTALYTTPVSTPQASIVSPEQSGTPATPARDANAAAATPGADGAGETDSDAVLSDITDQTWGAVVGHRLNNSSSVLEVHPALVSGYLIKRTGTKIEDAPVLMEVNLVHTDASPRAYEPLLREMLSYFRGLGTLARARGVVQRETDVRPWHVAAAEKAVRAMYLLM
Length1511
PositionKinase
OrganismTolypocladium ophioglossoides CBS 100239
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Ophiocordycipitaceae> Tolypocladium.
Aromaticity0.05
Grand average of hydropathy-0.286
Instability index45.80
Isoelectric point5.09
Molecular weight163089.81
Publications
PubMed=26215153

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP04587
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      88.42|      18|      20|     255|     272|       1
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  255-  272 (31.87/12.90)	VVDLVATSPAL.PGTPILA
  277-  295 (25.81/ 9.21)	VVALNQFSSAVeAGTPSLA
 1340- 1357 (30.73/12.21)	VVKLPQPSTAL.YTTPVST
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.81|      18|      20|     534|     553|       2
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  534-  553 (29.26/24.55)	LGEAEhvFGVMGEDMFGDND
  554-  571 (33.54/20.77)	ITEAD..FNFFDEQQPGDSD
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.42|      12|      20|     475|     493|       3
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  478-  489 (20.91/ 9.46)	VTPSFDGTLSSP
  495-  506 (20.50/11.39)	VAPATETDPAAP
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.33|      20|      20|     128|     147|       5
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  111-  130 (28.38/14.45)	QQQQQGIQTPTSSISSASAL
  131-  150 (32.95/18.05)	DQSQRNAFASASQGAVPSSQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.54|      19|      20|    1359|    1378|       6
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 1359- 1378 (28.52/18.96)	QASIVSPEQSGTPATPArDA
 1379- 1397 (32.02/16.78)	NAAAATPGADGAGETDS.DA
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.33|      14|      20|     303|     316|       7
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  303-  316 (27.51/18.53)	LSLRG..GPDVHDSLW
  324-  339 (21.82/12.81)	LKLRGvaSTSLSDCSW
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      71.99|      21|      21|     643|     663|       8
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  643-  663 (38.24/20.04)	ATKRESS.PFDPHTVFKRVRAS
  666-  687 (33.75/16.80)	ATERGSSiPLPDSTRMTRIFES
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      39.22|      12|      20|     582|     593|       9
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  582-  593 (21.30/12.42)	ANNASDE.APKAD
  600-  612 (17.92/ 9.09)	ANEAKPEpVPQRD
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.28|      18|      20|     698|     717|      10
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  700-  717 (32.14/22.03)	KYEQG..GQFDY.KKIARTEK
  719-  739 (25.14/ 9.40)	RLEPGmlPETDYlKRHGRQGR
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      34.09|      10|      15|     959|     970|      11
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  959-  970 (15.16/13.99)	IPGrdPNVEPLR
  977-  986 (18.94/ 9.36)	ISG..PHLEVRR
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     184.90|      61|     249|     893|     957|      12
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  794-  858 (93.39/44.09)	EEPTSP.LKSSVKLVALDDDATSQITSLRE.VEPLEEPNQHLAMElPRLSKPEIPEL..PLALlfsDPE
  893-  957 (91.51/55.03)	QEGISPhPDTNLSCQSLSVDARNAIRILRDfVPSLLRGAGGINLK.GFLDIPDIPLLgqPSRL...QPR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      36.12|      10|      20|     445|     456|      17
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  445-  456 (14.26/12.97)	PSAPSpvAIRRP
  466-  475 (21.86/11.67)	PTPPD..GIQHP
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.10|      19|      20|    1410|    1428|      18
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 1410- 1428 (31.22/21.11)	VVGHRLNNSSSVLEVHPAL
 1429- 1447 (30.88/20.79)	VSGYLIKRTGTKIEDAPVL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.84|      18|     467|     770|     791|      20
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  770-  791 (27.20/24.72)	VEGSLSDDDdssvGSDQDDSSY
 1239- 1256 (33.64/19.77)	VTAAWTDDR....GSQQETASY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      85.09|      25|    1086|      22|      46|      21
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   22-   46 (43.16/24.28)	RVYESPSDLPQSFASVALDIENTLR
 1070- 1094 (41.92/23.37)	RISTSPDATMTGHGSALIEIMETLR
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.39|      15|      28|     373|     388|      22
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  373-  388 (22.57/19.38)	PLCfRKRAVEVSSTSR
  403-  417 (28.82/18.91)	PLG.RARAWFNTATER
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP04587 with Med13 domain of Kingdom Fungi
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