<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP04586

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMPGIVSMEPAGQNGTRTDHDRDPAVNGVNGTSVGGSQGGAPDKGKAPVASIDNGTVKGGEVGGSALERSRQPPLQASGPSTEAHSRMNDLPDEIRHITEGFIPLSLLLTRLAQVTHNSLQEKIAELAKMPVPTTAANGTPSHTSSGPDDSSSDNLRKKGSLTSFAQDMHGKWLKALVITEWSRKSEMVSKLIDLKFHIDQQRMLYDASLDDIVNVKRDLAFARMPSPDLKTALQVLSTGTAPWMPDLNYIDPPPLTPDEQLKWMNDLNTLLSLRLNLEDYDKIPYHFRNYEIGSGRVTFKVDGEFEVDLTIADEDFEKQFWFIDFRYAFTPAAASLSESLRTYLEGCVNEALSKDGLAGCYQFLHEFVLTCKINELKRQALQLSRSSWTGILMVEPLNRALAIQYWTSRTAVTGTKSWILLAVNSGRKPDGKTDPKSSSFLVAKWYRDNKEMKDVNIELDVKNLSAEALLTDVVDRHIAVILMSIHDKLLTVARFKNRETSMVLDVSKSDPAASHLAVQVGYRSQATVLVEPMTGVFAVKPHSKFTIQYEHQLNNGKNAAEDGVACLENVRCAIMEDEINRRGSCMGWLACRSPLTLEEMRSVTKLREWTRAIWLQKDGWGANWFVVVFLGLGGDDWWLLEANRDETNRAVKFKAQLPLSKGYPDQSEAFWNNLALFATGIITQSVDMRELHRHKIQGKSSDNMDVSLPQQVRLPSTEISLSALFPAMVSRSEDGAEGGSSEGDLMAENIELFSLMQKHTGTALAPKQAWADNIATIYFKGIQSLSKSADETREDGTPANELICVSHAIIKVQRPAKFEALTNMVDRDVSYNPRRGEFSLRILRPVGKPILDALKSRIKAIDRFVNFFEALENANGTIITSGSVTLKQVTFCYGERPEQDEGNGQGETQTLKQWRVVLDLSKDEIDIKIEAGNPHLRVVDLMRRLVNSDGGIGALMAWLPASLPALKSIDEMESRWANLQAEKRGRLEFSMKTIAWISIGYNMTASQGKKQIKKHVALEVRMKPRRGEAWWHVYRSDAGASAALEDEFTKALKPIWAARAEDWLGLTTGAAGRPSGGVVSMLLAVDDAIRGTVQAGPSSSPQTKKQSQSQSQSQSQSQAAAHDIMDLD
Length1128
PositionTail
OrganismTolypocladium ophioglossoides CBS 100239
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Ophiocordycipitaceae> Tolypocladium.
Aromaticity0.07
Grand average of hydropathy-0.360
Instability index41.04
Isoelectric point6.13
Molecular weight124855.32
Publications
PubMed=26215153

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU365082
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP04586
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     324.47|     107|     385|     561|     680|       1
---------------------------------------------------------------------------
  561-  680 (170.96/122.45)	EDGVACLENVrcAIMEDEINRRGSC...MGWLacrsPLTLEEMRSVTKLR.EWTRaiwLQKDGWGANWF...VVVFLGLG..........................GDDWWLLEANRDETNRAV..KF.KAQLPLskgYPDQSEAfWNNLALFATG
  930- 1072 (153.51/81.69)	EAGNPHLRVV..DLMRRLVNSDGGIgalMAWL....PASLPALKSIDEMEsRWAN...LQAEKRGRLEFsmkTIAWISIGynmtasqgkkqikkhvalevrmkprrGEAWWHVYRSDAGASAALedEFtKALKPI...WAARAED.WLGLTTGAAG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     218.10|      68|     362|     390|     478|       2
---------------------------------------------------------------------------
    3-   67 (104.99/43.92)	GIVSMEPAGQNGTRTDHDRDPAVNGVNGT.SVGGSQGGAPDkGKA.PVAS...IDNGTVKGGEVGGSALE
  390-  458 (113.47/51.77)	GILMVEPLNRALAIQYWTSRTAVTGTKSWiLLAVNSGRKPD.GKTDPKSSSFLVAKWYRDNKEMKDVNIE
  508-  523 (-0.36/14.10)	...........................................KSDPAASHLAVQVGYR...........
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     119.59|      37|     466|     318|     354|       3
---------------------------------------------------------------------------
  318-  354 (66.01/40.99)	KQFWFIDFRYAFTPAAASLSESL.RTYLEG.......CVNEALSK
  767-  811 (53.58/31.98)	KQAWADNIATIYFKGIQSLSKSAdETREDGtpaneliCVSHAIIK
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP04586 with Med14 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) EKIAELAKMPVPTTAANGTPSHTSSGPDDSSSDNLRKKGS
2) MPGIVSMEPAGQNGTRTDHDRDPAVNGVNGTSVGGSQGGAPDKGKAPVASIDNGTVKGGEVGGSALERSRQPPLQASGPSTEAHSRMNDLPDEIR
3) TVQAGPSSSPQTKKQSQSQSQSQSQSQAAAHDIMDLD
121
1
1092
160
95
1128










Molecular Recognition Features






MoRF SequenceStartStop




NANANA