<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP04581

Description Mediator of RNA polymerase II transcription subunit 12
SequenceMGVPPRQPQRGPSSTLAVQRPAHHQRSLSQQYLSTSTSPIRKDAHPDLTNEPVDAAQGRHHVSTPRRGGSKLRLELSNDLGNGPASATESPQVLTPSRMMPMSDATDMDTMSPALSRASQQEPDNVPMPMPRRRPQASQLPAGTLRTSTLAPAQVKKDSRPKPYTVEVPPAAPRFVSTNRHDAPNRDLFSKGLFSGHADFFPWSGRHHEDEWSHDAIGKGTWDRGSQNEAASARLAIPPLKQKSGLNALATIFMGVLNQRRHRGQITAPSTFKPPPRVTLTDTKREVWLKDLANPTISLRRLSRTIPHGIRGRTLLDQCLNKTVPTERAVWLAKCVGANEIRAFKRKGAGGAFVMGGESKWVRDWTVLVEQFVEAVVSAFGEADWKARVTYAIRLATSLYSEQLLDRDHYLDWIVCGLESSPQSRIPMWIVIAQITWVDLLRSRKYGRRLTYALLGHLHAIYNDPDRDVLIQLSSQISGLLKALIQRNPESFISPNLWPRYRDTLRASLPVDDGLSQGAYHKVDARNSRLLVANTTSGPAGRQDLVKLVDSAVQGQNGRHLAAKCWATLDDKSEIVKIAVEWATSVHRPGLAKIYIVARLIKSWSTFNINATQPILDVLSDIRPGDRRRSKCVFHLVAELVRSRLFSVPHYMQWLIGRGGLHDAADIDPNNGPCASRLLIELPVHCLPESQKAQRSNLLRRAGQYSTTDEAHDISNALRCVDDTLGLSPHLANSDAQTKCFPLRKLLRRVSNSSKAVQTAIGAHLGDVFTTELLGKVDSIIALSIFHSVRAMLETVDDFFMLSHILKVCSTASDVEVLAACVDTVNSHLEVFLALECADALFGLLIDRLKAVSSEQGVVARPLLAALSSLARRLPFQQEIAIQLVRELAQSDRSNAIDACSPVSDNMAMQTQGAEGEVSEQIDKLLASGNIIDHPTMNRLFRIIIPKLEAGWAKGDESRRVFSSLLTRLRIFDTQHFDKLMADWVSHIRTLMDRPPLLELFPLLVSLGCLSISTMLHTANAGTPAAEEAPLYPGVTPSGSAVYLQELLQLLITALPKSTSLDSDEIYRFEIQQKSARSEQPKGLLLMIRNALIEYSALRDRGPGRDFLLDDAAYEDRLLETLKYLVVADSTAVAHVLNIGNLPVGATALVHKIITKLLIPDDNGGLETSFDQILGLANELTMPFCQLKLNLDLSVPQRSSGAGEMDDDNPSRFEAFAKAMDRAIEARNIMWTGMLPCLSQDITRNLSNQAHARFLDLMPSLKSTSFEDDAISEHRIHLAENLLGVLEAINSGQLPSKSAQLTANLVEKLSDLLEIVASKDEERAQAQKEVLSHWLPVLLRFITLNSISPEPLQSSNPNQSNAARIPVPLNHEARARMIIVLCGLLLELDSQPQTTGGALSQEVFDIAVLLVDALPDDLRVQCARLILFMPGGAASTSTTSDPRLYYLFSVPQPTSAENLKLTHRDKASIPYSAAARGMSAMYGMGPASQERLTPFMLRRWEILSEPTPNVGENDTSLSLSLFEAIRTQ
Length1528
PositionKinase
OrganismTolypocladium ophioglossoides CBS 100239
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Ophiocordycipitaceae> Tolypocladium.
Aromaticity0.06
Grand average of hydropathy-0.199
Instability index45.04
Isoelectric point7.84
Molecular weight168567.88
Publications
PubMed=26215153

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. Component of the srb8-11 complex. The srb8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The srb8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
ECO:0000256	ARBA:ARBA00002895
ECO:0000256	ARBA:ARBA00003744
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP04581
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     172.67|      44|      45|     658|     701|       1
---------------------------------------------------------------------------
  455-  500 (57.79/27.20)	L....GHLH.AI..YNDPDRDvliQLSSQIsgLLKALIQRNPESFIS..PNLWPR
  508-  547 (37.31/15.19)	SlpvdDGLSQGAyhKVDARN.......SRL..LVANTT.....SGPAGRQDLVK.
  658-  701 (77.57/38.79)	R....GGLHDAA..DIDPNNG...PCASRL..LIELPVHCLPESQKAQRSNLLRR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     392.80|      86|     271|    1136|    1225|       2
---------------------------------------------------------------------------
 1136- 1219 (129.22/77.05)	.....VLNIGNLPVGATALVHKIITKL......LIPDDNGGLETSFDQ........ILGLANELTMPFCQLKLNLDLSVPQRSSGA..G...EMDDDNPSRFEAFAKA
 1224- 1285 (55.13/34.17)	IEarnIMWTGMLPCLSQDITRNLSNQAharfldLMPSLKS...TSFED.............DAISEHRIHLAENL.LGV.............................
 1286- 1362 (84.95/44.94)	LE...AINSGQLPSKSAQLTANLVEKL.........SDLLEIVASKDEeraqaqkeVLSHWLPVLLRFITLN..........SISP..E...PLQSSNPNQSNA....
 1364- 1405 (34.27/13.89)	.........................RI......PVPLNH...EARARM........IIVL........CGLLLELD.SQPQTTGGAlsQ...EVFD............
 1408- 1477 (89.23/50.45)	.....VLLVDALPDDLRVQCARLI..L......FMPGGAASTSTTSDP.......................RLYYLFSVPQPTSAE..NlklTHRDKASIPYSAAARG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     128.10|      29|     144|      31|      61|       3
---------------------------------------------------------------------------
   33-   61 (51.96/33.13)	LSTS..T...SPIRKDAHPDLTNEPVD..AAQGRHH
  145-  174 (34.41/13.64)	LRTS..TlapAQVKKDSRPKPYTVEVP..PAAPR..
  176-  208 (41.73/18.98)	VSTNrhD...APNRDLFSKGLFSGHADffPWSGRHH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.45|      13|      17|     566|     578|       5
---------------------------------------------------------------------------
  566-  578 (22.43/12.58)	WATLDDKSEIVKI
  582-  594 (24.02/13.98)	WATSVHRPGLAKI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.98|      13|      17|    1089|    1101|       6
---------------------------------------------------------------------------
 1089- 1101 (22.02/13.40)	RNALIEYSALRDR
 1105- 1117 (22.96/14.30)	RDFLLDDAAYEDR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.93|      16|      17|     292|     307|       7
---------------------------------------------------------------------------
  292-  307 (26.29/16.76)	LANPTISLRRLSRTIP
  310-  325 (27.64/18.06)	IRGRTLLDQCLNKTVP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      32.56|      10|      18|     939|     948|      16
---------------------------------------------------------------------------
  939-  948 (16.82/ 8.98)	RLFRIIIPKL
  960-  969 (15.74/ 7.92)	RVFSSLLTRL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP04581 with Med12 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) MGVPPRQPQRGPSSTLAVQRPAHHQRSLSQQYLSTSTSPIRKDAHPDLTNEPVDAAQGRHHVSTPRRGGSKLRLELSNDLGNGPASATESPQVLTPSRMMPMSDATDMDTMSPALSRASQQEPDNVPMPMPRRRPQASQLPAGTLRTSTLAPAQVKKDSRPKPYTVEVPPAAPRFVSTNRHDAPNRDLF
1
189










Molecular Recognition Features






MoRF SequenceStartStop




1) KLRLEL
2) MGVPPR
71
1
76
6