<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP04576

Description Mediator of RNA polymerase II transcription subunit 16
SequenceMQVGNSTELPQLPTRNWCESYDETLANEGRIRCMTWSTLNLIAVASSNGAQTPRGVTGKRKRDRNRESLMRPHISIFQSTEGGNQLVEICNLHRVPELHGGNAITCVQWDQHGKYLSSVDQTGRIIIWQLKGCINQWDAVHTVDLDEPVVAFQWLQEDRLWGVDLSSGKFAPTQMSDAQAGAGLSYFRTPFMGPKPPLSDPGFIVLSRSGKIHVFQLVSSGQVETFSVQIPGLEVLDTHMAVDGAPVHHGKAGNGVTHADIHLRKANSFTAAIYCPDALDSSVCLYDFQVNFSSLLIHCTGRRILRRDQGEHTAAMISDGALSHLRILGQSRVIFVVSNRMPDAGELLDRKGAPSDDDSRGSSVYICEWTSMSDDNPSNDSNQGWAISANYHVTGDFVSALEVMERSESGRSDGSRVILLGYSSGKCEMRDGDTLLKTDLGRFTFSPYKDSATENLSEPAIQQAAGRETAIATGLDEDPGINTNSPASCLTEGDGISEVHRASTEPAHGDYQKMSSICGNYSSSGGSTKRNGWNLPIINFAVSPNSVEILVAKDDTERGVIIDLMKHDIENIEALESHTIVEALSTKLAIALANRVEYIDLLFATRAYVDETGLKDLTIQIMRRVYAKHAEIMSLSGWTPATTFPYNAALSVENGPVGLQLAMYRMIPSHEQLYANTQVWIQLQSVLAQCYSAFEQPEAAWEVIANLLQKSDVQDLERAGKLQAAMIVRKECLQPLVAFALWLSDFCTTLLRQVYCLLNMEQKSLETAGEGRPLHRYPSVLPFLFHTGIRRTILSILFIMIYLEYNIHLRRSMWKNNAELQGFLIELALLFRRSRVKFVPFAGFLADIGKEVSEKLQEQSIDETQRLIMEQNMLVQGTVDEAYTSSLSAVRTAFETRICDIFPPDTPLVDPVLSSSPDDLLAMRLGPSITTLFKAPKSQVWPLDTITDDIWGTPFAEKYTSDRNNFILEEISGRLDVMPPAKRKKVDAIRSHIDVVTKARLSRADTVRQCIRCLQFSRGNASGPDSESEHFRGADTLMSEIGLLAKGPVVWRGAFRNCCICGGSWREVLDIS
Length1072
PositionTail
OrganismSpizellomyces punctatus (strain DAOM BR117)
KingdomFungi
LineageEukaryota> Fungi> Fungi incertae sedis> Chytridiomycota> Chytridiomycota incertae sedis> Chytridiomycetes> Spizellomycetales> Spizellomycetaceae> Spizellomyces.
Aromaticity0.07
Grand average of hydropathy-0.204
Instability index43.89
Isoelectric point5.57
Molecular weight118815.49
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364149

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP04576
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      66.83|      20|      26|     106|     129|       1
---------------------------------------------------------------------------
  106-  129 (33.32/35.71)	CV.QWDQhgkyLSSVDQTGRIIIWQ
  133-  153 (33.51/22.71)	CInQWDA....VHTVDLDEPVVAFQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.73|      17|      20|     807|     826|       2
---------------------------------------------------------------------------
  807-  824 (26.82/28.22)	IHLRRSmWKNNAELQGFL
  829-  845 (29.91/16.69)	LLFRRS.RVKFVPFAGFL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     260.38|      84|     599|     349|     447|       3
---------------------------------------------------------------------------
  349-  447 (122.66/100.85)	DRkgaPSDDDSRGSSVYICewTSMsDDNPSNDSNQgwaiSANYHVTGDFVSalEVMERS.ESGRSDGSRV..ILLGY.SSGKCEMRDGDTLlktDLGRFTFSP
  457-  544 (137.72/74.52)	SE...PAIQQAAGRETAIA..TGL.DEDPGINTNS....PASCLTEGDGIS..EVHRAStEPAHGDYQKMssICGNYsSSGGSTKRNGWNL...PIINFAVSP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     114.46|      35|     258|     644|     680|       4
---------------------------------------------------------------------------
  644-  680 (57.96/55.98)	FPYNAAL...SVENGPVGLqLAMyRMIPSHEQLY..ANTQVW
  902-  941 (56.50/42.63)	FPPDTPLvdpVLSSSPDDL.LAM.RLGPSITTLFkaPKSQVW
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP04576 with Med16 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) ENLSEPAIQQAAGRETAIATGLDEDPGINTNSPASCLTEGDGISEVHRASTEPAH
454
508










Molecular Recognition Features






MoRF SequenceStartStop




NANANA