<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP04572

Description Cyclin-dependent kinase 8
SequenceMDYDFKMKTQKERTKVEDLFNYEGCKVGRGTYGHVYKAKWKETSDGKEYALKQIDGTGLSMSACREIALLRELKHQNVITLIRVFLSHTDRKVFLLIDYAEHDLWHIIKFHRAAKAAKKPVVVPKGMVKSLLYQILDGIHYLHSNWVLHRDLKPANILVMGDGPERGRVKIADMGFARLFNAPLKPLADLDPVVVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPYHHDQLDRIFNVMGFPQDKDWEDIKKMPEHHTLTKDFKRSSYSTCSLAKYMDRHKIKPDSKAFHLLQRLLLMDPNKRITSEQAMQDPYFQEDPLPTQDVFAGCAIPYPKREFLTDDDQEDKSDTKRQQQQQQQQQQQQQQQQQQQQQQQQHQHEPNSKRVRLSGPGGPQQPQQVHQQQQDFHHQQQQQAAAAAAAAAQQQQQQAAAQQMMFNQQQQNFQQRF
Length468
PositionKinase
OrganismLucilia cuprina (Green bottle fly) (Australian sheep blowfly)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Brachycera> Muscomorpha> Oestroidea> Calliphoridae> Luciliinae> Lucilia.
Aromaticity0.09
Grand average of hydropathy-0.818
Instability index52.15
Isoelectric point8.86
Molecular weight54590.34
Publications
PubMed=26108605

Function

Annotated function 
GO - Cellular Component
GO - Biological Function
ATP binding	GO:0005524	IEA:UniProtKB-UniRule
protein serine/threonine kinase activity	GO:0004674	IEA:UniProtKB-KW

GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP04572
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|      99.66|      14|      15|     371|     384|       1
---------------------------------------------------------------------------
  371-  384 (28.45/11.48)	KRQQQQQQQQQQQQ
  387-  400 (24.88/ 9.05)	QQQQQQQQQQHQHE
  420-  433 (23.75/ 8.28)	VHQQQQDFHHQQQQ
  452-  465 (22.59/ 7.49)	AQQMMFNQQQQNFQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      92.85|      31|      35|     122|     154|       2
---------------------------------------------------------------------------
  122-  154 (48.99/35.67)	VVPKGMVKSLLyQILD.GIHYLHsNWVLH..RDLKP
  159-  192 (43.86/23.59)	VMGDGPERGRV.KIADmGFARLF.NAPLKplADLDP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.49|      16|      27|     239|     256|       3
---------------------------------------------------------------------------
  239-  256 (23.05/25.13)	EDIKTSnPYHHdQLDRIF
  268-  283 (31.44/21.16)	EDIKKM.PEHH.TLTKDF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.39|      14|      20|     329|     344|       4
---------------------------------------------------------------------------
  329-  344 (23.11/16.71)	AMqdPYFQEDPLPTQD
  350-  363 (26.28/12.74)	AI..PYPKREFLTDDD
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP04572 with CDK8 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) IPYPKREFLTDDDQEDKSDTKRQQQQQQQQQQQQQQQQQQQQQQQQHQHEPNSKRVRLSGPGGPQQPQQVHQQQQDFHHQQQQQAAAAAAAAAQQQQQQAAAQQMMFNQQQQNFQQRF
2) PNKRITSEQAMQDPYFQEDPLPTQDVFAGC
351
320
468
349










Molecular Recognition Features






MoRF SequenceStartStop




1) QQQHQHEPNSKRVRLSGP
394
411