<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP04571

Description Mediator of RNA polymerase II transcription subunit 13 (Fragment)
SequenceMTHQSHQTNGASLEDCHTNFFALTDLCGIKWRKFVNNERPNASSDPLDDPILRSYSRCMQADILCVWRRVQSTRQDNSDPSAMFDVNTSKVHPPLSLAAAKELWIFWYGEEPDLADLVDAELLKVADNQMMWNGTWERGLTYECRSLLFKALHNLIERFVLTKDIVRFGKWFVQPCTSNERIFGRSSQHLSFSFTFFVHGDTVCASIDLREHPAVRPLTKEHLTEAAAAFAAAASNANSPEQQTSPNSPNAAAAHAAEGIKNENASSNNNNNNNNNTSNNNSNNNSSSSNNNNNSNSVNPKPRKVILAPFGMAATLTGNSYKTNDPMAEKILDDWASFFPLCNKENSDVPPVVEVIAGGHKMYHPSIYVLVTDLDDMEEMEAAASQKCPLGTSSSAEAAALAALSSANQTTSCSGGGGGGNTHNNHSYNDSRKPLMENFSNNKLPTINGTKSSLAHMVERLKIDRSKVQPYYDTQTRNFTCNTTNIHAPPQAACEMPERAWQDCVTNVLHVQHSLNGTILSTSSSSNSLAANTNNSSTSNTTSSNTSTTSAVTTTTSSSGINNNDNNATTSEGMDQTDNVSNSVDIKPNTSTLSQKQQQQQIWGFVDPTQKAPCICTKSLTSSQTPSSGQTPGHGTPLQGGISSYSRNSLIDCMPIPSVGSPGTPAASPHPNSALSQPTSVPPADQLLSMSPRAPTSVSNLQQPPTPIDHLLDKNTPAPTPTDQHDNKSITASPYVHPTPSVEPPPSVEGMHNTIGGGGVGGNMGPGSVPPPSSVGRCTPTPQQQQQHQQCGSISVKKFDLQPASLPTPLNNANMHMSGNATSSNCPTNNSIDIKLESTANSNNINNPNCIMNSSVLPNNNVNRNESPLSSATNAMQNFLNLYKPPKINVKDIDSVANEDCLKLDVLYDFTVQNA
Length915
PositionMiddle
OrganismLucilia cuprina (Green bottle fly) (Australian sheep blowfly)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Brachycera> Muscomorpha> Oestroidea> Calliphoridae> Luciliinae> Lucilia.
Aromaticity0.05
Grand average of hydropathy-0.601
Instability index45.27
Isoelectric point5.79
Molecular weight98424.47
Publications
PubMed=26108605

Function

Annotated function 
GO - Cellular Component
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP04571
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     120.31|      18|      18|     258|     275|       1
---------------------------------------------------------------------------
  258-  275 (32.21/13.41)	EGIKNENASSNNNNNNNN
  279-  296 (34.12/14.71)	NNNSNNNSSSSNNNNNSN
  550-  567 (25.13/ 8.60)	SAVTTTTSSSGINNNDNN
  847-  863 (28.85/11.13)	NPNCIMN.SSVLPNNNVN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     120.24|      24|      24|     673|     696|       2
---------------------------------------------------------------------------
  673-  696 (41.21/17.35)	SALS..............QPTSVP.PADQLLSMSPRAPT
  699-  720 (28.06/ 9.40)	SNLQ..............QP...PtPIDHLLDKNTPAPT
  728-  746 (26.38/ 8.38)	KSIT..............ASPYVH.PTP...SVEP..PP
  747-  783 (24.58/ 7.30)	SVEGmhntiggggvggnmGPGSVP.PPSSVGRCTP.TPQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     146.51|      37|     279|     512|     548|       3
---------------------------------------------------------------------------
  512-  548 (62.22/27.61)	QHSLNGTILSTSS...S....SNSLAANTNNSS...TSNTTSSNTST
  599-  625 (30.03/ 9.48)	QQQIWGFVDPTQK...ApcicTKSL...............TSSQT..
  787-  828 (54.26/23.13)	QHQQCGSI.SVKKfdlQ....PASLPTPLNNANmhmSGNATSSNCPT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.37|      13|      23|     219|     231|       4
---------------------------------------------------------------------------
  219-  231 (21.78/11.39)	TKEHLTEAAAAFA
  244-  256 (23.59/12.96)	TSPNSPNAAAAHA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     211.11|      65|     395|      36|     104|       6
---------------------------------------------------------------------------
   36-  104 (109.36/72.44)	NNERPNASSDPLDDPILRSYSRCMQADILCVWRRVQSTRQDNSDPSAMFD.......vNTSKVH.PPlslAAAKEL....W
  424-  501 (101.76/57.53)	NNHSYNDSRKPLMENFSNNKLPTINGTKSSLAHMVERLKIDRSKVQPYYDtqtrnftcNTTNIHaPP...QAACEMperaW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.64|      15|      23|     326|     340|       7
---------------------------------------------------------------------------
  326-  340 (28.52/20.63)	PMAEKILDDWASFFP
  351-  365 (28.11/20.23)	PVVEVIAGGHKMYHP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP04571 with Med13 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) AFAAAASNANSPEQQTSPNSPNAAAAHAAEGIKNENASSNNNNNNNNNTSNNNSNNNSSSSNNNNNSNSVNPKPRK
2) CICTKSLTSSQTPSSGQTPGHGTPLQGGISSYSRNSLIDCMPIPSVGSPGTPAASPHPNSALSQPTSVPPADQLLSMSPRAPTSVSNLQQPPTPIDHLLDKNTPAPTPTDQHDNKSITASPYVHPTPSVEPPPSVEGMHNTIGGGGVGGNMGPGSVPPPSSVGRCTPTPQQQQQHQQCGSISVKKFDLQPASLPTPLNNANMHMSGNATSSNCPTNNSIDIKLEST
3) LNGTILSTSSSSNSLAANTNNSSTSNTTSSNTSTTSAVTTTTSSSGINNNDNNATTSEGMDQTDNVSNSVDIKPNTSTLSQKQQQQQIWG
4) TSCSGGGGGGNTHNNHSYNDSRKPLMENFSNNKLPTINGTKSSLAHMVER
229
614
515
411
304
839
604
460










Molecular Recognition Features






MoRF SequenceStartStop




NANANA