<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP04563

Description Mediator of RNA polymerase II transcription subunit 12
SequenceMLSLLQEKRPLKRARLGPPDVYPQEAKQREDELTPSNVKHGFATMPPLADEFGTAHTSNVNASKVASFFNAILAKKEELMTVQDTVRKKQQINCKDNFWPVSPRTKGALDAWFKDLAGNKPLLSLAKKAPSFNKKEEILITLCDHQVNMQRATWFIKLSAAYMVSVSESKNKKRNSFDPVPEWTSNLIKFMKDLLPKLQEYYHLSEKCTPAEKALLSGYGAPCTQNNNQQQNTSSAHPTNSLTTVPQSLASPVSMLSPHNSQSSSASGLGSLTVSSTPGVGSSNSQSGLPGANNMPGSGSSISGIGSNFEDSRNALKYWNYCTQLSKYMHEESLLDRQEFLNWILELLDKMRTQVSFDESLKKLILTFALQYMHDFVQSERLCRKMAYIVAKKLANLLNNVIEQQPNNKQMLPAGITHMDVDEDNETKKKFNLDPYESAINEYLNCPHHRDIILYLSTILQIITIECPTAMVWCGIGENRIPAALCGSPLDHLPIAPSALPMPSKCTLTNAEVRRQLRCTEAEIVLRSKHAENRWFAEKWQNANKNSYTHVLSILDHLDTHCFDLMDQTNSIDSLYASIFQPFVSVRREMGANGEMKEIRQEYDANTVDGTTVKILCEWAVSSQRWGEHRAIVVAILLDKRQIEVTTPSAEDNNNGLGSGNNPNDDKDSIASGAGLIGGLPVFQSVLMNFLDHDAPVLDENGSLANRTQFTNLVHLFSALIRHDVFSHNAYMHTLISRGDLLEGATTGAATTTTTSTTSVGNSLNNNNKNSNMAVVGNSVTGPVSNKPVSPAVNHGFDDEFGAGLDFKHNEFDDSNVDDDLDKLLQNIKEKGQAEAPDSPKIPDHNNSAGCNETNSSISRHYIYTKHFPIPQDDPSMIYSSESNQRYILLFGVGKERDEKKHAVKKMSKEICKLFTKKFSIDVAEGGKVKKHSRNEFNFENTTSKCQNMAYFDQHVVTSQCAATVLEQLNGFAVGNNNYLPVQEHVAFLFDLMEMALNIHSLLELCDQILKELPEVENQLQAKKSNMVRSYTTSLGLYIVGILRRYHSCLLLSPEQTVSVFEGLCRIIKHVNNPCECSSAERCILAYLSDLYETCLILRSKDQEAEFFPQMSHIKKFKDIFNQPEQLGMVPQSYNPQFMQDFLSSPKRGGKIDSLWLRQLHESPANIYSFVSNVIFAVCHETDNDRLNDIAIACAELTAGCNSLSEEWIAALQSICHAMKKTRYPHLCQIDIQNSKIHNSLAVFICILVARHCFSLADFVMKIALPTLANAYPVGGEITTDAESGK
Length1286
PositionKinase
OrganismLucilia cuprina (Green bottle fly) (Australian sheep blowfly)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Brachycera> Muscomorpha> Oestroidea> Calliphoridae> Luciliinae> Lucilia.
Aromaticity0.07
Grand average of hydropathy-0.367
Instability index50.86
Isoelectric point6.16
Molecular weight143521.20
Publications
PubMed=26108605

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP04563
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     184.06|      55|     220|     915|     974|       1
---------------------------------------------------------------------------
  915-  974 (88.03/76.18)	FTKKFSIDVAEGGKVkkhsrNEFNFENTTSKCQNMAYFDQHVVTSQCAATVLEQLNGFAV
 1138- 1192 (96.03/70.31)	FMQDFLSSPKRGGKI.....DSLWLRQLHESPANIYSFVSNVIFAVCHETDNDRLNDIAI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     164.05|      50|     219|     161|     219|       2
---------------------------------------------------------------------------
  161-  219 (78.00/62.47)	AYMVSvseskNKKRNSFDPVPEWTSNlikfMKDLLPKLQEYYHLSEKCTPAEKALLSGY
  387-  436 (86.04/50.10)	AYIVA.....KKLANLLNNVIEQQPN....NKQMLPAGITHMDVDEDNETKKKFNLDPY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      76.21|      25|      33|     241|     271|       4
---------------------------------------------------------------------------
  241-  271 (36.85/31.50)	SlttvpqSLASPVSMLSPHN..SQSSSASGLGS
  281-  307 (39.36/20.95)	G......SSNSQSGLPGANNmpGSGSSISGIGS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     110.78|      23|     690|     545|     567|       5
---------------------------------------------------------------------------
  545-  567 (44.23/27.15)	KNSYTHVLSILDHLDTHCFDLMD
  977-  994 (28.63/15.09)	.NNY...LPVQEHVA.FLFDLME
 1238- 1258 (37.92/22.27)	HNSLAVFICIL..VARHCFSLAD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      83.37|      24|      45|    1046|    1069|       6
---------------------------------------------------------------------------
 1046- 1069 (43.72/30.06)	YHSCLLL.SPEQTVSVFEGLCRIIK
 1092- 1116 (39.65/26.52)	YETCLILrSKDQEAEFFPQMSHIKK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     156.85|      51|     687|      53|     110|       9
---------------------------------------------------------------------------
   53-  110 (70.54/74.37)	GTAHTSNVNASKVASFFNAIlAKKEELMTVQDTVrkKQQINCKdnfwPVSPRTKGALD
  748-  798 (86.31/62.74)	GAATTTTTSTTSVGNSLNNN.NKNSNMAVVGNSV..TGPVSNK....PVSPAVNHGFD
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP04563 with Med12 domain of Kingdom Metazoa
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