<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP04560

Description Mediator of RNA polymerase II transcription subunit 15
SequenceMSEEWQSQKFRQNVIAKINDMLQSTGQDGIKNASVMENHIFKKSKNKDEYLGLVAKLFMHFKDLSQRRPQQAPQPNAEMGQQNMMQDPLNALQNLASQGNRNPQMMSMPGGPNVQQGAGPGGPVPASNLLQTLNQQRPGQQQMQQMQGIRPQMTMGAGGPGQQQGNIVGGGPGQQQMMPQMGGPGGLQMNVMGGPNGGPNQQMVGNAQQMGGPSGGPGVGPGGPQGMPGQLNQMGGPNTGGPMGPGSSGPGGPNQMQMNSGGQIQGGPVVTMNVQQLPNQMQQQQMQQMGMQHPQLNQMMNARMNQGGPVVTMNVAGPNAGANQGMQGIPPNMQQNQVGGVGTGGPMHPNNVGNAGQQGQQGGMPHAAGSQGNLNQMLNIPPGMQKNPNMTMGQGQQMFNVNRGVVGQQQFHRQSPSPSTVSSPAGGLNVQQQQQLQQQVVNNQQQQQLQQNNQAGGGPQGPQSLPNPQMIPSPALVPSSSPQMPGLMQNPNQRQQMRQSPSAPLNTPGQVTQNSPFNAQEDQLYREKYKQLTKYKETLMRMVAKFRNDGNNAESYTKMSKLLEILSNPMKRVPLETLLKCEKVLENMKISPFCGQTFGKSSNPLMEVINTTLQSPIANHTLYRTFRPSLELLFGTDISAPAPPKMRRLSEKPTISADIEIPHVLQGEIARLDQKFKVTLDPTAQNNIKSIKLICCLDDKKLPSVPPVSVNIPEDYPWASPECSLIEQDYSATVFLKAVQNALMSRIAKLPKLYSLSHLLDTWEMSVRQACSPNAVKPVCEFTALLGM
Length788
PositionTail
OrganismLucilia cuprina (Green bottle fly) (Australian sheep blowfly)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Brachycera> Muscomorpha> Oestroidea> Calliphoridae> Luciliinae> Lucilia.
Aromaticity0.03
Grand average of hydropathy-0.675
Instability index59.92
Isoelectric point9.51
Molecular weight84964.00
Publications
PubMed=26108605

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364148
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP04560
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             9|     443.63|      40|      40|     160|     199|       1
---------------------------------------------------------------------------
   70-  103 (39.91/ 6.40)	QQA.P..QP..NAE.MG..QQ.NMMQDPlN...............A.LQNLAS.Q...G.NRNP
  104-  141 (53.81/11.54)	QMM.S..MP..GGP.NVQ.QG.A...GP...GGP.....vPA..SN.LLQTLN.Q...QrPGQQ
  142-  175 (65.61/15.91)	Q.M.Q..QM..QGI.RP..QM.T.MGA....GG.......PG..QQ.QGNIVG.G...G.PGQQ
  176-  223 (67.62/16.65)	QMM.P..QM..GGP.GGL.QM.NVMGGP.N.GGPnqqmvgNA..QQ.MGGPSG.GpgvG.PGG.
  224-  256 (47.03/ 9.03)	....P..Q...GMP.G...QL.NQMGGP.NtGGP....mgPG...S.SG...P.G...G.PNQM
  257-  297 (40.65/ 6.67)	QMN.SggQI.qGGP..VV.TM.NVQQLP.N.Q..........mqQQ.QMQQMGmQ...H.PQLN
  298-  334 (49.64/10.00)	QMMnA..RMnqGGP..VV.TM.NV.AGP.N.AGA...........N.QG.MQG.I...P.PNMQ
  362-  409 (39.08/ 6.09)	GGM.P..HA..AGSqGNLnQMlNIPPGM.Q.KNP.nmtmgQG..QQ.MFNVNR.G...V.VGQQ
  410-  448 (40.29/ 6.54)	QFH.R..QS..PSP.STV.......SSP.A.GGL...nvqQQ..QQlQQQVVN.N...Q.QQQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      73.19|      22|      22|     637|     658|       2
---------------------------------------------------------------------------
  637-  658 (37.23/27.93)	DISAPAPPKMRRLSEKPTISAD
  660-  681 (35.96/26.67)	EIPHVLQGEIARLDQKFKVTLD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.75|      13|      15|     462|     474|       3
---------------------------------------------------------------------------
  462-  474 (27.73/11.84)	PQSLPNPQMIPSP
  504-  516 (23.02/ 8.33)	PLNTPGQVTQNSP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      79.13|      22|      22|     591|     612|       5
---------------------------------------------------------------------------
  591-  612 (40.33/27.89)	SPFCGQTFGKSSNPLMEVINTT
  615-  636 (38.80/26.54)	SPIANHTLYRTFRPSLELLFGT
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP04560 with Med15 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) KDLSQRRPQQAPQPNAEMGQQNMMQDPLNALQNLASQGNRNPQMMSMPGGPNVQQGAGPGGPVPASNLLQTLNQQRPGQQQMQQMQGIRPQMTMGAGGPGQQQGNIVGGGPGQQQMMPQMGGPGGLQMNVMGGPNGGPNQQMVGNAQQMGGPSGGPGVGPGGPQGMPGQLNQMGGPNTGGPMGPGSSGPGGPNQMQMNSGGQIQGGPVVTMNVQQLPNQMQQQQMQQMGMQHPQLNQMMNARMNQGGPVVTMNVAGPNAGANQGMQGIPPNMQQNQVGGVGTGGPMHPNNVGNAGQQGQQGGMPHAAGSQGNLNQMLNIPPGMQKNPNMTMGQGQQMFNVNRGVVGQQQFHRQSPSPSTVSSPAGGLNVQQQQQLQQQVVNNQQQQQLQQNNQAGGGPQGPQSLPNPQMIPSPALVPSSSPQMPGLMQNPNQRQQMRQSPSAPLNTPGQVTQNSPFNAQEDQLYREK
62
528










Molecular Recognition Features






MoRF SequenceStartStop




NANANA