<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP04559

Description Mediator of RNA polymerase II transcription subunit 24
SequenceMKENKILKLIHVAWRERWSDSQWGINIKNVLPRGVSGDVYNLSDCILQQALIGSTANPLVLNYLKHSLCAHLVSYSAVLRRISKYEYFERIYCITSLLDFLNSILDGVTCRTKTEESILPGAIVSLVNWLMQIFAMVATNYEINREINAEQSYMLDQCCAVIEKLVKNQFLLAILYVGRQEDLEYYSKIRENYATIKTSLTNSNFTPSHPGIEKYLQQLAYIDVHHLEMKTLDVKQLPEPITYCVQPLLAVEVLLNPCNDTSYYVAEMQMLQRLKKFSNTRLFYEIIRAGFVSLSNVVETSHDTTWGAFTFFKVPQIIKQLHALNRAPGDQNPPDFIPEVVEALEMLLEDNLLLDFMDSKCSCNIIEYLLNDWTKQHLVNDAHVKHFAAQREEVSMLLQKRETGNHMQPSIINFIIRAEVPLSGILKTLSADYNKVQEALLGVLCQVLVGNSFDLILSVATVEGRLKTFVSRLIQCNENSKQIPGEVGKTSIIRSTLFDVSFLMLTSIVQTYGSEALLSENGDSFFEKWVRICMVERNKPKNYHNMIAMCDENIVDELLLSFSKPEAQLKNSNITWQDICLNLPGVIYHVLLAWEKETLSSADVKNILDNIKRRMFSFSVCAASFLCAYMHSVKKXXPPGNEELSSQENFKERLGLSLQIIRKMQYDVHPTGNLKSRNVTLTQNLVSRNPLIDQFKDVWNTVVEHGWVPVRTAQIIESLLHAGGPAWLSTRLVEEMLKCKYKKDMMKTMDIIFAILHLDIERTTEALLTNVVPSIIHNRQGDDINEPQSYVLARLCVYCIISALEARSQNSPTQKKRTRSHDGDEHDLNAAKMRKITADGSDNSCSNDFLSENSLLLSSSVSLHSNSLRETPAQLKESLQSAMQYIFKVFQQFVTTDELSPKIYFVYQFITLLVECGKERVRPVLKQLPPNLINNLIKVMLTDDINVGLITRLYDLRVINGRQSAVSDLCLWRNIKLKQQSIQL
Length984
PositionTail
OrganismLucilia cuprina (Green bottle fly) (Australian sheep blowfly)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Brachycera> Muscomorpha> Oestroidea> Calliphoridae> Luciliinae> Lucilia.
Aromaticity0.08
Grand average of hydropathy-0.097
Instability index39.92
Isoelectric point6.56
Molecular weight112129.36
Publications
PubMed=26108605

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP04559
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     109.04|      34|     203|     153|     212|       3
---------------------------------------------------------------------------
  153-  186 (59.04/67.85)	YMLDQCCAVIEKLVKN.....QFLLAI.LYVGRQEDLEYY
  225-  264 (50.00/17.81)	HHLEMKTLDVKQLPEPitycvQPLLAVeVLLNPCNDTSYY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      90.71|      27|     203|     330|     360|       5
---------------------------------------------------------------------------
  330-  356 (45.53/24.14)	DQNPPDFIPEVVEALEMLLEDNLLLDF
  536-  562 (45.18/23.87)	ERNKPKNYHNMIAMCDENIVDELLLSF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     148.79|      49|     167|     477|     529|       7
---------------------------------------------------------------------------
  477-  529 (74.52/52.17)	NENSKQipgEVG.KTSIIRSTLFDVSFL.MLTSIVQTYgSEALLSENG..DSFFEKW
  647-  699 (74.27/40.50)	QENFKE...RLGlSLQIIRKMQYDVHPTgNLKSRNVTL.TQNLVSRNPliDQFKDVW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     138.04|      44|     803|     108|     152|       8
---------------------------------------------------------------------------
  108-  152 (70.05/53.69)	VTCRTKTEESILPGAIVSLVNWLMQIF.......AMVATNYEInREINAEQS
  914-  964 (67.99/46.96)	VECGKERVRPVLKQLPPNLINNLIKVMltddinvGLITRLYDL.RVINGRQS
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP04559 with Med24 domain of Kingdom Metazoa
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