<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP04559

Description Mediator of RNA polymerase II transcription subunit 24
SequenceMKENKILKLIHVAWRERWSDSQWGINIKNVLPRGVSGDVYNLSDCILQQALIGSTANPLVLNYLKHSLCAHLVSYSAVLRRISKYEYFERIYCITSLLDFLNSILDGVTCRTKTEESILPGAIVSLVNWLMQIFAMVATNYEINREINAEQSYMLDQCCAVIEKLVKNQFLLAILYVGRQEDLEYYSKIRENYATIKTSLTNSNFTPSHPGIEKYLQQLAYIDVHHLEMKTLDVKQLPEPITYCVQPLLAVEVLLNPCNDTSYYVAEMQMLQRLKKFSNTRLFYEIIRAGFVSLSNVVETSHDTTWGAFTFFKVPQIIKQLHALNRAPGDQNPPDFIPEVVEALEMLLEDNLLLDFMDSKCSCNIIEYLLNDWTKQHLVNDAHVKHFAAQREEVSMLLQKRETGNHMQPSIINFIIRAEVPLSGILKTLSADYNKVQEALLGVLCQVLVGNSFDLILSVATVEGRLKTFVSRLIQCNENSKQIPGEVGKTSIIRSTLFDVSFLMLTSIVQTYGSEALLSENGDSFFEKWVRICMVERNKPKNYHNMIAMCDENIVDELLLSFSKPEAQLKNSNITWQDICLNLPGVIYHVLLAWEKETLSSADVKNILDNIKRRMFSFSVCAASFLCAYMHSVKKXXPPGNEELSSQENFKERLGLSLQIIRKMQYDVHPTGNLKSRNVTLTQNLVSRNPLIDQFKDVWNTVVEHGWVPVRTAQIIESLLHAGGPAWLSTRLVEEMLKCKYKKDMMKTMDIIFAILHLDIERTTEALLTNVVPSIIHNRQGDDINEPQSYVLARLCVYCIISALEARSQNSPTQKKRTRSHDGDEHDLNAAKMRKITADGSDNSCSNDFLSENSLLLSSSVSLHSNSLRETPAQLKESLQSAMQYIFKVFQQFVTTDELSPKIYFVYQFITLLVECGKERVRPVLKQLPPNLINNLIKVMLTDDINVGLITRLYDLRVINGRQSAVSDLCLWRNIKLKQQSIQL
Length984
PositionTail
OrganismLucilia cuprina (Green bottle fly) (Australian sheep blowfly)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Brachycera> Muscomorpha> Oestroidea> Calliphoridae> Luciliinae> Lucilia.
Aromaticity0.08
Grand average of hydropathy-0.097
Instability index39.92
Isoelectric point6.56
Molecular weight112129.36
Publications
PubMed=26108605

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP04559
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     109.04|      34|     203|     153|     212|       3
---------------------------------------------------------------------------
  153-  186 (59.04/67.85)	YMLDQCCAVIEKLVKN.....QFLLAI.LYVGRQEDLEYY
  225-  264 (50.00/17.81)	HHLEMKTLDVKQLPEPitycvQPLLAVeVLLNPCNDTSYY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      90.71|      27|     203|     330|     360|       5
---------------------------------------------------------------------------
  330-  356 (45.53/24.14)	DQNPPDFIPEVVEALEMLLEDNLLLDF
  536-  562 (45.18/23.87)	ERNKPKNYHNMIAMCDENIVDELLLSF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     148.79|      49|     167|     477|     529|       7
---------------------------------------------------------------------------
  477-  529 (74.52/52.17)	NENSKQipgEVG.KTSIIRSTLFDVSFL.MLTSIVQTYgSEALLSENG..DSFFEKW
  647-  699 (74.27/40.50)	QENFKE...RLGlSLQIIRKMQYDVHPTgNLKSRNVTL.TQNLVSRNPliDQFKDVW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     138.04|      44|     803|     108|     152|       8
---------------------------------------------------------------------------
  108-  152 (70.05/53.69)	VTCRTKTEESILPGAIVSLVNWLMQIF.......AMVATNYEInREINAEQS
  914-  964 (67.99/46.96)	VECGKERVRPVLKQLPPNLINNLIKVMltddinvGLITRLYDL.RVINGRQS
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP04559 with Med24 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




NANANA









Molecular Recognition Features






MoRF SequenceStartStop




1) DYAQL
2) LQNQSLKRLELEN
54
86
58
98