<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP04552
Description |
Mediator of RNA polymerase II transcription subunit 17 |
Sequence | MNFTNSVNVSVETTCESKIQEIGYDGTEIYEPPPTLSETLKKCAAKIDFSKTSLEELKKEEKAQADEADKDAQFQPSLWPWDSVRNKLNDALTEVCVLADVISIAKDKRYLVLDPVPDTEPEKNNAIIQVYSRKKALNQAAQILLSGAERLKNTHTEQRNRNVSDFHIELLRLRQNWRLKKVSNAIIGDLSYRTAGSKFGMSGTFEVTKAEDVADEEAAGTSTSLATTGANNGLPNPSPKNNSALRVIVPAELQGVAYFKVITQKDQEDLCTATVNLMGHGPNTTQQGGVWQKTIEDAQNVLFCKELFSQLAREAIQLQAPIPHVVIGNQIRATLLPGIQLIISLCHSTSVDSNQPTPINDHDHDHVLEHSLHQLLREVHHKNSHHPFPHPASGPLGPSKKRMLAGPMASDRQSLVEMTKYQTILEQIIAQAQHIFMRKRTQYVLDTLARDVKDPQIVSHWNAMTSPTMSCVKINIVTHGYDTINRTSLVIHVRERSLKAICRDGRVMHLSYEPQELRDLILCQINSHQISCLLNLARCMAWQVLSNSNHLGIGKVEPLGNASSCLLASPNSDRMIAVQIRCTQSQMDVKVYIAKSPRQDFFPNPLVPEKFWENLGGHFKEVRFDKIEGKSFLNKMEFLMASLNSSSA |
Length | 648 |
Position | Head |
Organism | Lucilia cuprina (Green bottle fly) (Australian sheep blowfly) |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota>
Neoptera> Endopterygota> Diptera> Brachycera> Muscomorpha> Oestroidea>
Calliphoridae> Luciliinae> Lucilia.
|
Aromaticity | 0.06 |
Grand average of hydropathy | -0.380 |
Instability index | 40.61 |
Isoelectric point | 7.09 |
Molecular weight | 72437.79 |
Publications | PubMed=26108605
|
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364140
|
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP04552
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 79.48| 22| 30| 352| 376| 1
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352- 376 (36.26/25.39) DSNQPTPindHDHDHVLEHSLHQLL
383- 404 (43.22/22.82) NSHHPFP...HPASGPLGPSKKRML
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 64.28| 18| 30| 254| 271| 5
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254- 271 (31.32/20.17) QGVAYFKVITQKDQEDLC
287- 304 (32.96/21.55) QGGVWQKTIEDAQNVLFC
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 69.34| 21| 33| 535| 556| 9
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535- 556 (33.04/25.03) NLARCMAWQVLSNSNHLGIgKV
571- 591 (36.30/22.35) NSDRMIAVQIRCTQSQMDV.KV
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|