<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP04549

Description Mediator of RNA polymerase II transcription subunit 26
SequenceMNNKHIHDLTLRLSQSLDQNYDVVSMETVLSVISALEGTTITKEQLEATRLAKYINQLRRRTKCENLARRAKSLLKKWREMVGIQQSSESSSAVVCSGAVTATGPTVSNPISTPTAPYNMPVTDNAVSTSHLKNPQISHQQQNRQNQYPTSVKQHQIQQQPYHSQPSSPVNLQDKSNPNEYLISMSNPATGSQMTKSSITNIRKKKRLEKSLNNELITQQQPKQQPTSFANLITGLGSTFPLEQKNPREKYEPVASTVNPVETFIIEHSSNSNSDLICLPSNNTVSNFTSATDVPPVVIDLQDTNSSMTSLVSKDVTNASSSYYKTKTSTKKSKKEKKRKDRNITSRKNQSIQDCEDQNTTTASYQHKRANDVLQLDEKSHSAGPTISNISEILSLSNSSMSSVFPSTDAISKNVFQSGQNDLAASSVKMSKADLTFAGKFKNTSSTSGGCNVLNYNSDSMNVNILTSNSPNQNKFSLFGGGVGTTNSNDSSSNSRNSQFNVVNAIKTEASNSKHNMEDILVKPDINDKSMSNMSNKGNSSTDNLFAGVGSSTITPSQQQQSIDLTTMDFSSQQAVKQPKKRGRKKGSKGVDSVIAKETSLSSQMLISSISVGGKKVKTTKELYAEMENRKLRNVKIVGLGETAGNSSGNWNAQQQQLQQKPVISRRPSYCSDIAESDSCTMTSEPSRDSGNTLSKNIGKRETPMDNNSNYSELKISIVKGDDGSTNTIDPNSTLAITTKIKKEIQEILKLLTPPPSIKEIEYDCYNNITPCTCTVEEVIVPAENDPNENSNGESSIADINLNVVAQPQIPKMENSSFTINNIRIATVSSPPKSNQNVSILPQPPPKIKKSIFDLDFDDDEDPLKSIIADIVGKNSKSDAEVETNVPVVDEKPDIPLSTDDDIGKVVDHQTAPSYALNVPTTSSDMIVFPSYEIKFDKDCEAKNRFDVQTQKITKFHIDTLHNCFIPNVNGNWNHSDYIASADCSSQTLERNLNGHDQGQEDLIMDGYDVVPLYGSDVNEQIIKDLSHVKFTKKYKFKHTKCKNEILFHIPFLGVSRTPDVACVSDVKMGNKYLHKIKLEEEKENDNKINFTNMKNNDILPNEKEGCDAKEMERVQNVDSLNTINLAPEKTNLKRTKEYKTLKRSRIKRIKSTISYDKNYEGNIKNKEFPKNNQHTSSSGGDSDSDSFDGDFVNDHNYVSEADQNISSQEQDSNISNEFEQEVVNQDISQHSEGKNHIVLIIKKTAGSPTSSNLKTNSPLNSLTHLSSENSREENVNLIFVANEVKNERNYHKSDSEGDIKMSSLQQQKRLRKKAIKRKNDNVTTHKLHNTLFYHEELFPMVWNGSYCHKERIFQISSCSSGCSEDEESANVNLTKKSTISSPLSSISSERSDNKYEGHMFNLQHDIIQSEFLKRCTMPTVQRDMEIDNLVSDNIKIQSEDEEGDDDDLPEENNHMLLSFNNICNKYTRDENADNYKQPQEENKDHEENNMLKQQQKNCDDYNNLNNNNFNLIKYIDNKTSSVNNINNNNNSCSNNYSDTNIVISSSSCSHKNPTNYALINQKNLNNNDNNSMKEEEIKPLKEYQTGIRAVDEDVNDDDGNNCARLQKFKEWHEVLQLRSYNDELLTVLPYVVLE
Length1635
PositionUnknown
OrganismLucilia cuprina (Green bottle fly) (Australian sheep blowfly)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Brachycera> Muscomorpha> Oestroidea> Calliphoridae> Luciliinae> Lucilia.
Aromaticity0.05
Grand average of hydropathy-0.852
Instability index53.66
Isoelectric point5.94
Molecular weight182858.45
Publications
PubMed=26108605

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP04549
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|    1090.55|     283|     316|     945|    1260|       1
---------------------------------------------------------------------------
  515-  798 (348.84/191.28)	HNMEDILVKPDINDKSMSN.......MSNKGNSSTDNL...........fAGVGSSTITPS..............QQQQSIDLTTMDFSS.....................QQAvkqpkKR...GRKKGSK.....GVDsVIAKETSLSSQMLISSISvggkKV...............................KTTKEL...YAEMENRKLRNVKIVGLGETA..........GNSSGNWNAQQQQLQQKPVISRRPSYCSDI..AESDSC...TMTSEPSRDSGNTL.skNIGKRETPM.....DNNSNYSELKISIVKgDDGSTNTIDPNSTLAITTK.IKKEIQEILKLLTPPPSiK....EIEYDCYNNITPCtctveevivpAENDPNENS.NGESSIA
  957- 1216 (385.09/241.58)	................................................H.IDTLHNCFIPNVN...........GNWNHSDYIASADCSS.....................QTL.....ERNLNGHDQGQEDLimdGYD.VVPLYGSDVNEQIIKDLS....HV...............................KFTKKYKFKHTKCKNEILFHIPFLGVSRTPDVAcvSDVKMGNKYLHKIKLEEEKENDNKINFTNMKNNDILPNEKEGCDakEMERVQNVDSLNTI...NLAPEKTNL.....KRTKEYKTLKRSRIK.RIKSTISYDKNYEGNIKNKeFPKNNQHTSSSGGDSDS.D....SFDGDFVNDHNYV..........SEADQNISSQEQDSNIS
 1217- 1572 (356.62/212.40)	NEFEQEVVNQDISQHSEGKnhivliiKKTAGSPTSSNLktnsplnsltH.LSS.ENSREENVNlifvanevkneRNYHKSDSEGDIKMSSlqqqkrlrkkaikrkndnvttHKL.....HNTLFYH....EEL....FP.MV.WNGSYCHKERIFQIS....SCssgcsedeesanvnltkkstissplssisseRSDNKYEGHMFNLQHDII.QSEFLKRCTMPTVQ..RDMEIDNLVSDNIKIQSEDEEGDDDDLPE.ENNHMLLSFNNICN..KYTRDENADNYKQPqeeNKDHEENNMlkqqqKNCDDYNNLNNNNFN.LIK....YIDNKTSSVNN....INNNNNSCSNNYSDT.NivisSSSCSHKNPTNYA..........LINQKNLNNNDNNS...
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      35.62|      14|      15|     140|     154|       2
---------------------------------------------------------------------------
  130-  150 (13.79/ 9.22)	ShLKNpqishQQQNRQNQyPT
  151-  167 (21.82/10.60)	S.VKQ..hqiQQQPYHSQ.PS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.12|      23|      58|     374|     401|       3
---------------------------------------------------------------------------
  277-  308 (29.79/12.98)	ICLPSNN.....TVSNftsatdVPPVvidLQDTNSSM
  374-  401 (32.33/26.76)	LQLDEKShsagpTISN......ISEI...LSLSNSSM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.67|      14|      15|     204|     218|       7
---------------------------------------------------------------------------
  204-  218 (18.25/15.04)	KKKRLEKSLNNeLIT
  221-  234 (25.42/16.16)	QPKQQPTSFAN.LIT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      67.39|      20|      92|     832|     856|       9
---------------------------------------------------------------------------
  801-  821 (31.28/16.91)	NLNVVAQPQiPKMENSSFTIN
  837-  856 (36.11/14.86)	NVSILPQPP.PKIKKSIFDLD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.27|      15|      18|     337|     354|      12
---------------------------------------------------------------------------
  340-  354 (25.32/19.32)	KDRNIT..SRKNQSIQD
  356-  372 (21.95/ 6.77)	EDQNTTtaSYQHKRAND
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP04549 with Med26 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) AESDSCTMTSEPSRDSGNTLSKNIGKRETPMDNNSNYSELKIS
2) FSLFGGGVGTTNSNDSSSNSRNSQFNVVNAIKTE
3) GKNHIVLIIKKTAGSPTSSNLKTNSPLNSLTHLSS
4) NERNYHKSDSEGDIKMSSLQQQKRLRKKAIKRKNDN
5) NYEGNIKNKEFPKNNQHTSSSGGDSDSDSFDGDFVNDHNYVSEADQNISSQEQDSNISNEFEQEVVNQDISQH
6) PSQQQQSIDLTTMDFSSQQAVKQPKKRGRKKGSKGVDSVI
7) SKHNMEDILVKPDINDKSMSNMSNKGNSSTDNLFAGVGSST
8) SYYKTKTSTKKSKKEKKRKDRNITSRKNQSIQDCEDQNTTTASYQHKRANDVLQLDEKSHS
9) TGPTVSNPISTPTAPYNMPVTDNAVSTSHLKNPQISHQQQNRQNQYPTSVKQHQIQQQPYHSQPSSPVNLQDKSNPNEYLISMSNPATGSQMTKSSITNIRKKKRLEKSLNNELITQQQPKQQPTSFANLITGLGSTFPLEQKNPREKYEPVASTVNPVETFII
10) TNYALINQKNLNNNDNNSMKEEEIKPLKEYQTGIRAVDEDVND
11) TRDENADNYKQPQEENKDHEENNMLKQQQKNCDDYNN
675
476
1234
1287
1159
556
513
322
103
1555
1468
717
509
1268
1322
1231
595
553
382
266
1597
1504










Molecular Recognition Features






MoRF SequenceStartStop




1) KKSIFDLDFD
2) LKSII
849
864
858
868