<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP04549

Description Mediator of RNA polymerase II transcription subunit 26
SequenceMNNKHIHDLTLRLSQSLDQNYDVVSMETVLSVISALEGTTITKEQLEATRLAKYINQLRRRTKCENLARRAKSLLKKWREMVGIQQSSESSSAVVCSGAVTATGPTVSNPISTPTAPYNMPVTDNAVSTSHLKNPQISHQQQNRQNQYPTSVKQHQIQQQPYHSQPSSPVNLQDKSNPNEYLISMSNPATGSQMTKSSITNIRKKKRLEKSLNNELITQQQPKQQPTSFANLITGLGSTFPLEQKNPREKYEPVASTVNPVETFIIEHSSNSNSDLICLPSNNTVSNFTSATDVPPVVIDLQDTNSSMTSLVSKDVTNASSSYYKTKTSTKKSKKEKKRKDRNITSRKNQSIQDCEDQNTTTASYQHKRANDVLQLDEKSHSAGPTISNISEILSLSNSSMSSVFPSTDAISKNVFQSGQNDLAASSVKMSKADLTFAGKFKNTSSTSGGCNVLNYNSDSMNVNILTSNSPNQNKFSLFGGGVGTTNSNDSSSNSRNSQFNVVNAIKTEASNSKHNMEDILVKPDINDKSMSNMSNKGNSSTDNLFAGVGSSTITPSQQQQSIDLTTMDFSSQQAVKQPKKRGRKKGSKGVDSVIAKETSLSSQMLISSISVGGKKVKTTKELYAEMENRKLRNVKIVGLGETAGNSSGNWNAQQQQLQQKPVISRRPSYCSDIAESDSCTMTSEPSRDSGNTLSKNIGKRETPMDNNSNYSELKISIVKGDDGSTNTIDPNSTLAITTKIKKEIQEILKLLTPPPSIKEIEYDCYNNITPCTCTVEEVIVPAENDPNENSNGESSIADINLNVVAQPQIPKMENSSFTINNIRIATVSSPPKSNQNVSILPQPPPKIKKSIFDLDFDDDEDPLKSIIADIVGKNSKSDAEVETNVPVVDEKPDIPLSTDDDIGKVVDHQTAPSYALNVPTTSSDMIVFPSYEIKFDKDCEAKNRFDVQTQKITKFHIDTLHNCFIPNVNGNWNHSDYIASADCSSQTLERNLNGHDQGQEDLIMDGYDVVPLYGSDVNEQIIKDLSHVKFTKKYKFKHTKCKNEILFHIPFLGVSRTPDVACVSDVKMGNKYLHKIKLEEEKENDNKINFTNMKNNDILPNEKEGCDAKEMERVQNVDSLNTINLAPEKTNLKRTKEYKTLKRSRIKRIKSTISYDKNYEGNIKNKEFPKNNQHTSSSGGDSDSDSFDGDFVNDHNYVSEADQNISSQEQDSNISNEFEQEVVNQDISQHSEGKNHIVLIIKKTAGSPTSSNLKTNSPLNSLTHLSSENSREENVNLIFVANEVKNERNYHKSDSEGDIKMSSLQQQKRLRKKAIKRKNDNVTTHKLHNTLFYHEELFPMVWNGSYCHKERIFQISSCSSGCSEDEESANVNLTKKSTISSPLSSISSERSDNKYEGHMFNLQHDIIQSEFLKRCTMPTVQRDMEIDNLVSDNIKIQSEDEEGDDDDLPEENNHMLLSFNNICNKYTRDENADNYKQPQEENKDHEENNMLKQQQKNCDDYNNLNNNNFNLIKYIDNKTSSVNNINNNNNSCSNNYSDTNIVISSSSCSHKNPTNYALINQKNLNNNDNNSMKEEEIKPLKEYQTGIRAVDEDVNDDDGNNCARLQKFKEWHEVLQLRSYNDELLTVLPYVVLE
Length1635
PositionUnknown
OrganismLucilia cuprina (Green bottle fly) (Australian sheep blowfly)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Brachycera> Muscomorpha> Oestroidea> Calliphoridae> Luciliinae> Lucilia.
Aromaticity0.05
Grand average of hydropathy-0.852
Instability index53.66
Isoelectric point5.94
Molecular weight182858.45
Publications
PubMed=26108605

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP04549
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|    1090.55|     283|     316|     945|    1260|       1
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  515-  798 (348.84/191.28)	HNMEDILVKPDINDKSMSN.......MSNKGNSSTDNL...........fAGVGSSTITPS..............QQQQSIDLTTMDFSS.....................QQAvkqpkKR...GRKKGSK.....GVDsVIAKETSLSSQMLISSISvggkKV...............................KTTKEL...YAEMENRKLRNVKIVGLGETA..........GNSSGNWNAQQQQLQQKPVISRRPSYCSDI..AESDSC...TMTSEPSRDSGNTL.skNIGKRETPM.....DNNSNYSELKISIVKgDDGSTNTIDPNSTLAITTK.IKKEIQEILKLLTPPPSiK....EIEYDCYNNITPCtctveevivpAENDPNENS.NGESSIA
  957- 1216 (385.09/241.58)	................................................H.IDTLHNCFIPNVN...........GNWNHSDYIASADCSS.....................QTL.....ERNLNGHDQGQEDLimdGYD.VVPLYGSDVNEQIIKDLS....HV...............................KFTKKYKFKHTKCKNEILFHIPFLGVSRTPDVAcvSDVKMGNKYLHKIKLEEEKENDNKINFTNMKNNDILPNEKEGCDakEMERVQNVDSLNTI...NLAPEKTNL.....KRTKEYKTLKRSRIK.RIKSTISYDKNYEGNIKNKeFPKNNQHTSSSGGDSDS.D....SFDGDFVNDHNYV..........SEADQNISSQEQDSNIS
 1217- 1572 (356.62/212.40)	NEFEQEVVNQDISQHSEGKnhivliiKKTAGSPTSSNLktnsplnsltH.LSS.ENSREENVNlifvanevkneRNYHKSDSEGDIKMSSlqqqkrlrkkaikrkndnvttHKL.....HNTLFYH....EEL....FP.MV.WNGSYCHKERIFQIS....SCssgcsedeesanvnltkkstissplssisseRSDNKYEGHMFNLQHDII.QSEFLKRCTMPTVQ..RDMEIDNLVSDNIKIQSEDEEGDDDDLPE.ENNHMLLSFNNICN..KYTRDENADNYKQPqeeNKDHEENNMlkqqqKNCDDYNNLNNNNFN.LIK....YIDNKTSSVNN....INNNNNSCSNNYSDT.NivisSSSCSHKNPTNYA..........LINQKNLNNNDNNS...
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      35.62|      14|      15|     140|     154|       2
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  130-  150 (13.79/ 9.22)	ShLKNpqishQQQNRQNQyPT
  151-  167 (21.82/10.60)	S.VKQ..hqiQQQPYHSQ.PS
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.12|      23|      58|     374|     401|       3
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  277-  308 (29.79/12.98)	ICLPSNN.....TVSNftsatdVPPVvidLQDTNSSM
  374-  401 (32.33/26.76)	LQLDEKShsagpTISN......ISEI...LSLSNSSM
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.67|      14|      15|     204|     218|       7
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  204-  218 (18.25/15.04)	KKKRLEKSLNNeLIT
  221-  234 (25.42/16.16)	QPKQQPTSFAN.LIT
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      67.39|      20|      92|     832|     856|       9
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  801-  821 (31.28/16.91)	NLNVVAQPQiPKMENSSFTIN
  837-  856 (36.11/14.86)	NVSILPQPP.PKIKKSIFDLD
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.27|      15|      18|     337|     354|      12
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  340-  354 (25.32/19.32)	KDRNIT..SRKNQSIQD
  356-  372 (21.95/ 6.77)	EDQNTTtaSYQHKRAND
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP04549 with Med26 domain of Kingdom Metazoa
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