<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP04545

Description Mediator of RNA polymerase II transcription subunit 12
SequenceMYSVSTSPNPLNAVSSSSNIKLSCDRHLLIAAHKNIPLEAVLAVLKAILIVVDTTALKTPTMTGNTSTGAFGSGGKRGSGFNTPVHPGSTPKSNDRPVDISQILGTSDLTSLTGDHDHDMSQPLSTTPLNPSVSGSGEQISLLEFAQHVLKQICAQEHVLERCLKNADKLCDMIIDDMLTPKQSQSILHMICYSEAEYSIISEMDQKSMIVRILENLGQWTLRISWLDLQLMHKQSMNNGTELTAWLDTVARAAIDVFLMEEVLMPNGGKAEHRPKPSTWLVAPLVSKLTPAVQGRILRVAGQVLESMNYFSKTSKADNNSSCSGDEREKSNSCGSASSSYSNGSNSGTRNKKMPLNYQPFLGLILTCLKGQDEYKENLLVSLYSQLSQCLQSYAEFDTMGGVDDPLGREEMLDALQLRFSLVGGMFDSIQKNGTSITDWAILLAQLVCQGVIDLSTNRELFTTVVDMLTTLVHSTLVSDGQSERDEKFYSNLMKKLKKEIGEKNNASIKVIRQLLPLYKHQTEVISCEPAGVDQKGNKINDMDKKQLRISDKQRISVWDILEGHKNPAPLSWVWFGAVKLERKPLTYEEAHRNLKYHTHSLVKPSSYYYEPLPLPPEEEPVPEKIVTPTPFLQKDEMKADTPSSVDQSPSAVVSGRGRKGTTRKRKPKNPKTPPVNTQQQPPLAGQQTQPGAQQTANQQQQPQQQQLGQQTQQQQQVTQQQQQLNPQQQMGQMQMNMQMGSNVNMQQFNPNQMMQQNPNAMMQQQQMQGVPGNMQQQMNVGNPQQNQQMNFMGPGGTQAMQQGGMNPQQQQWQGQNQFHPMQQQQPQQQFYQQQQGMQMNRPQINNSKQALHNMLRQRQPTFNQNNPSFNPMQQQQHRQGQGMQPQQQPGAINTVQQQQQLQQQQFGRTGMRTMAPNQMAGVAPNQMAPNMNAVGMAGQGMGAQNPMMQQQMSTQGMNPQATAQMGMNQSGNMMGAGNANNPNAMMSGQSNTGMVNAGAMMQQNVGVAGVGNANVNQGMVNATGPGQFQNFNQYQQGMNQTGGPNQQANLMGGFNQMNQRSNPAEFMAQQQRGPGGPMAGNRGQYMNQTPNVTMNNMMGQGAVPPYQRQQSTGGKPGVQQQQFQQQQQQQQRMQHQMMQMQGMGPQSNAAGGMGQAQNQAQQQNPNLVAQLQRQMPNQPNMMGQQYQHQPPPY
Length1194
PositionKinase
OrganismLucilia cuprina (Green bottle fly) (Australian sheep blowfly)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Brachycera> Muscomorpha> Oestroidea> Calliphoridae> Luciliinae> Lucilia.
Aromaticity0.05
Grand average of hydropathy-0.770
Instability index45.86
Isoelectric point8.94
Molecular weight132227.95
Publications
PubMed=26108605

Function

Annotated function 
GO - Cellular Component
GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP04545
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      80.42|      21|      21|     766|     786|       3
---------------------------------------------------------------------------
  766-  786 (47.30/12.64)	QQMQGVPGNMQQQMNVGNPQQ
  825-  845 (33.12/ 6.52)	QQPQQQFYQQQQGMQMNRPQI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     109.62|      21|      21|     857|     877|       4
---------------------------------------------------------------------------
  712-  732 (33.42/ 7.81)	TQQQQQVTQQQQ.QLNPQQQMG
  857-  877 (44.88/13.50)	RQRQPTFNQNNP.SFNPMQQQQ
  879-  900 (31.32/ 6.77)	RQGQGMQPQQQPgAINTVQQQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             7|     323.50|      35|      36|     915|     949|       5
---------------------------------------------------------------------------
  741-  793 (40.26/ 9.72)	G.S...NvN....MQQFNPNQMMQQ.N.PNAMMQQ.....qqmqgvpgnmqqqmnvgnpqqNQQMNFM
  794-  823 (53.14/15.99)	G.P...........GGTQAMQQG.GMN.PQQQQWQ...GQ.....................NQFHPMQ
  915-  949 (71.93/25.13)	MAP...N.Q....MAGVAPNQMAPNMN.AVGMAGQ...GM.....................GAQNPMM
  976- 1002 (36.16/ 7.72)	GAG...N..........ANN...PN...AM.MSGQsntGM.....................VNAGAMM
 1043- 1079 (44.80/11.93)	GGP...N.QqanlMGGF..NQMNQRSNpAEFMAQQ...QR.....................GPGGPM.
 1106- 1139 (40.23/ 9.71)	..PyqrQ.Q....STGGKPGVQQQQFQ.QQQQQQQ...RM.......................QHQMM
 1171- 1192 (36.99/ 8.13)	QLQ...R.Q....M....PNQ..PN......MMGQ...QY.....................QHQPP..
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      59.30|      18|      24|     391|     414|       6
---------------------------------------------------------------------------
  391-  410 (27.77/32.15)	LQsyAEFDTMGGVDDPLGRE
  416-  433 (31.53/15.41)	LQ..LRFSLVGGMFDSIQKN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      83.75|      24|      26|     215|     240|       7
---------------------------------------------------------------------------
  217-  240 (46.07/33.46)	LGQW..TLRISWLDLQLMHKQSMNNG
  243-  268 (37.68/19.57)	LTAWldTVARAAIDVFLMEEVLMPNG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      71.86|      20|      24|     302|     325|       8
---------------------------------------------------------------------------
  306-  325 (36.36/27.24)	ESMNYFSKTSKADNNSSCSG
  329-  348 (35.50/16.47)	EKSNSCGSASSSYSNGSNSG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      68.56|      21|      24|     563|     586|       9
---------------------------------------------------------------------------
  563-  586 (35.28/31.94)	EGHKNpapLSWVWFGAVK.....LERKPL
  590-  615 (33.28/20.33)	EAHRN...LKYHTHSLVKpssyyYEPLPL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      72.54|      20|      23|      95|     114|      10
---------------------------------------------------------------------------
   90-  109 (34.95/26.19)	TPKSNDRPVDISQILGTSDL
  110-  129 (37.59/28.87)	TSLTGDHDHDMSQPLSTTPL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      69.67|      22|      24|     620|     643|      11
---------------------------------------------------------------------------
  620-  643 (33.93/23.33)	EPVPEKIVTPTPflQKDEMKADTP
  647-  668 (35.73/18.53)	DQSPSAVVSGRG..RKGTTRKRKP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     112.94|      36|      46|     474|     509|      13
---------------------------------------------------------------------------
  474-  509 (59.74/37.66)	HST.LVSDGQSERDEKFYS.NLMKKLKKEIGEKNNASI
  521-  558 (53.19/32.73)	HQTeVISCEPAGVDQKGNKiNDMDKKQLRISDKQRISV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      37.57|      10|      19|    1140|    1149|      18
---------------------------------------------------------------------------
 1140- 1149 (19.82/ 8.43)	QMQGMGPQSN
 1156- 1165 (17.74/ 6.51)	QAQNQAQQQN
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP04545 with Med12 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) KADNNSSCSGDEREKSNSCGSASSSYSNGSNSGT
2) SSYYYEPLPLPPEEEPVPEKIVTPTPFLQKDEMKADTPSSVDQSPSAVVSGRGRKGTTRKRKPKNPKTPPVNTQQQPPLAGQQTQPGAQQTANQQQQPQQQQLGQQTQQQQQVTQQQQQLNPQQQMGQMQMNMQMGSNVNMQQFNPNQMMQQNPNAMMQQQQMQGVPGNMQQQMNVGNPQQNQQMNFMGPGGTQAMQQGGMNPQQQQWQGQNQFHPMQQQQPQQQFYQQQQGMQMNRPQINNSKQALHNMLRQRQPTFNQNNPSFNPMQQQQHRQGQGMQPQQQPGAINTVQQQQQLQQQQFGRTGMRTMAPNQMAGVAPNQMAPNMNAVGMAGQGMGAQNPMMQQQMSTQGMNPQATAQMGMNQSGNMMGAGNANNPNAMMSGQSNTGMVNAGAMM
3) TMTGNTSTGAFGSGGKRGSGFNTPVHPGSTPKSNDRPVDI
4) VGNANVNQGMVNATGPGQFQNFNQYQQGMNQTGGPNQQANLMGGFNQMNQRSNPAEFMAQQQRGPGGPMAGNRGQYMNQTPNVTMNNMMGQGAVPPYQRQQSTGGKPGVQQQQFQQQQQQQQRMQHQMMQMQGMGPQSNAAGGMGQAQNQAQQQNPNLVAQLQRQMPNQPNMMGQQYQHQPPPY
316
606
61
1011
349
1002
100
1194










Molecular Recognition Features






MoRF SequenceStartStop




1) LVAQL
2) YYYEPLPL
1168
608
1172
615