<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP04542

Description Mediator of RNA polymerase II transcription subunit 23
SequenceMDVQILDCVNNYLKVEPIEEAFLSVIVYRPDGEQDKASKFSNDIVTAFGSIPQDSKEGIVRQYLEKAASATNTNQLKVLMGTLGKLAESHLITAKLLCDKILLCEKLNYENKNFWIESFRLIKKVIDHVDYKGVREIMKACRDKAQRFPLNVNVTYLPQLLALEDTIRYIFDRNNCLLPAYFIANEIIKPFPYHWKLNKLMTDVVEEFRQTAQMVSIIGHTHMLPIVEHFGYADHMMNSWKLDPNTLKFNFKGSLPYEPELMEEQPQLLRYVLEQTYSKEMISIMLNLQKHQKQRCNTLEDQLVNLIINAMEMTESNENIAGSSFNVPEEQIPQNEWIWLHLSSQLIYFVLFHFVSFTHIVLALYDKLSKIELRKGRDQLMWILLQFISGSIQKNPIGNFLPMFKLFDLLYPEQEPLPLPDCNKSFSLRQMAPICIWIHLMKKTRNENMNITRPLPIALKNHHDFLQHLVLPTTMMSMSLSNDFRIVLVCNAYSTNQEFFARPMNILVEALNGNAKSANGAAIQPLPYSMVVLDSLTVHSKMSLIHGFVTQMIKQAQTKNSVPTPALIETYARLLVYTEIESLGIKGFLLQLFPAVFKHHAWGILHILLEMFSYKMHHIPTHYRIQLLSNLHSLVHVPQSNKMQLNLCFESTSLRLINGMGSVEFQPQLSRYFNEKPPASVTSAESEELNRVLILTLARAMHVTGSGEEMQAWCKELLSNIMQSTPHAWAPHSLACFPPALAEFFAQNNHPIENKALLKKSVEEEFRNWSSMTNENDIINHFIKPNTSPLFLCLLYKMIWETDNINPVAYKILEGISARALSANLRKLCDYLISEVVSSNGKEFIHKSVDSINNMIWKYNVVTIDRVVLCLALRTLEGSEAQVCFLIIQLLLLKTSELRNRVTEFCKENNPDHWKQINSHEKHLSFHQKYPEKFAPDESASHPPLPVYFSNVCLRFLPVLDVVIHRFIEMPIQHVHQILEVILDHLSVLYKFHDRPITYLYNTLHFYERILRDRPSLKRKLVSAVTGSFCDIRPPNWCVSEQYKLFLQSTDLLWNPDLSYYMNLIKRLAETINGKNVFFNTDWRFNEFSNAPAHAMYVTCVELLSLPVAPQIVANNIIDVIVKGYALIPQKEIHSYINAVGIVLAELPEAYWSGIYERLQEVLNLPNMLRWNYRFNAFEMFNFKLVREAMVEKTFAVVLAVAHSIFHHMGGFKLATMTKYIKETLKPRVVTEHQLVFLCHVFGPFLQRIEQEKPNAVAGIAILLYEMLEVVDKQHGPTPLEYMDPICDFLYHIKYIHVGNIIKNESEAIIKRLRPALQMRLRFISHLNIEDKHIEKPCEQTATTTTAANTVMGQPTMGAQTMQFQANTMQQNFSNLSNQQQQQTQQQQQSMQQNVTNNPGQQTQQGNQQQQQQQQQQQQQSQNQPQQLNQQQQQLHQMQLQQLHQQQLQQQQLQLHIQQQQQMQQQQQQQQSQNQPQQLNQQQQQLHQMQLQQLHQQQLQQQQLQLHIQQQQQMQQQQQQQQQLSQPSNMGGGMRHN
Length1537
PositionTail
OrganismLucilia cuprina (Green bottle fly) (Australian sheep blowfly)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Brachycera> Muscomorpha> Oestroidea> Calliphoridae> Luciliinae> Lucilia.
Aromaticity0.09
Grand average of hydropathy-0.288
Instability index50.28
Isoelectric point7.15
Molecular weight178549.09
Publications
PubMed=26108605

Function

Annotated function 
GO - Cellular Component
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP04542
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             7|     223.32|      18|      18|    1430|    1447|       1
---------------------------------------------------------------------------
 1375- 1391 (25.52/ 6.10)	NL........SNQQ..QQ.Q.tQQQQQSM
 1392- 1416 (27.94/ 7.25)	QQnvtnnpgqQTQQGNQQ.Q...QQQQQQ
 1417- 1436 (34.05/10.16)	QQ........QQSQNQPQ.QlnQQQQQLH
 1437- 1456 (34.79/10.50)	QM........QLQQLHQQ.QlqQQQLQLH
 1462- 1479 (27.68/ 7.13)	QM........QQQQQQQQsQ..NQPQQL.
 1488- 1507 (34.79/10.50)	QM........QLQQLHQQ.QlqQQQLQLH
 1508- 1525 (38.57/12.30)	IQ........QQQQMQQQ.Q..QQQQQLS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     221.44|      53|      54|     382|     435|       2
---------------------------------------------------------------------------
  337-  380 (70.64/38.47)	WIWLH.LSSQ.........LIY.FV.LFHFVSFTHIVLALYDKLSKIELRKGRDQL
  382-  435 (91.69/56.77)	WILLQFISGSIQKNpIGNFLPM.FK.LFDLLYPEQEPLPLPDCNKSFSLRQMAPIC
  437-  480 (59.11/30.97)	WIHLMKKTRNENMN.ITRPLPIaLKnHHDFL....QHLVLPTTMMSMSL.......
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      69.73|      20|     132|     600|     619|       3
---------------------------------------------------------------------------
  600-  619 (39.67/18.63)	HAWGILHI......LLEMFSYKMHHI
  727-  752 (30.06/12.61)	HAWAPHSLacfppaLAEFFAQNNHPI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     144.06|      33|      88|    1056|    1088|       4
---------------------------------------------------------------------------
 1056- 1088 (57.95/35.41)	PDL..SYYMNLIKRLAETINGKNV..FFNT.DWRFNEF
 1110- 1147 (32.30/16.49)	PQIvaNNIIDVIVKGYALIPQKEIhsYINAvGIVLAEL
 1148- 1178 (53.80/32.35)	PE...AYWSGIYERLQEVLNLPNM..L.RW.NYRFNAF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     151.66|      53|      55|     804|     858|       7
---------------------------------------------------------------------------
  798-  854 (72.64/67.88)	MIWEtdNINPVAyKILEGISARALSANLRKLCdYLISEVV...SSNGKEFIHKSVDSINN
  855-  911 (79.02/61.64)	MIWK.yNVVTID.RVVLCLALRTLEGSEAQVC.FLIIQLLllkTSELRNRVTEFCKENNP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.95|      19|     470|     229|     256|      10
---------------------------------------------------------------------------
  191-  209 (36.81/14.61)	FPY......HWKL..NKLMTDVVEEFR
  230-  256 (25.14/31.62)	FGYadhmmnSWKLdpNTLKFNFKGSLP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.23|      16|      20|    1336|    1354|      11
---------------------------------------------------------------------------
 1337- 1353 (24.82/17.80)	PCEQTATTTTAANTvMG
 1355- 1370 (30.41/17.71)	PTMGAQTMQFQANT.MQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.30|      12|      99|     664|     675|      20
---------------------------------------------------------------------------
  263-  274 (22.75/10.68)	EEQPQLLRYVLE
  664-  675 (24.55/12.06)	EFQPQLSRYFNE
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP04542 with Med23 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) IEKPCEQTATTTTAANTVMGQPTMGAQTMQFQANTMQQNFSNLSNQQQQQTQQQQQSMQQNVTNNPGQQTQQGNQQQQQQQQQQQQQSQNQPQQLNQQQQQL
1334
1435










Molecular Recognition Features






MoRF SequenceStartStop




NANANA