<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP04539

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMWTNIFRIGGLQQLSWFQFLPNESDVTSSLPDKRDGAAFELLSSHLQLQKDGFLSTWTNSFVGPWDPSQGTHNPDEKIKLWLFLPGRHSSVSETAQAAVSRLRVVASGLWISPGDSEEVTTALSQALKNRIERALIGLSYVRYGDVFSRYRPFSQSEELFRKGQPTIEFVFAASEDAIFVHAILSAKHVRTLSGGDMEKVLKLSSSSLGQRLPVIVSPHGMRGKVTGCCPSDLVKQVFVGPGTSRTSTGLVGLPNPVAHTSGGKLRGQNYYLEVTLGCSTSGSDKVNLHTSNTNKSNQPTSGSPSSVKGNQKVSTGDASFCEKTFIYPSEAVLVPVLQTSYARSSLKRFWLPNWTGLSLAGSTLLTNCCGSETDDLDDSWYESDGNSLQHGLNSSSNSNNSSISSISNSSSDSDCRAKATSGDLEGDADSLTGRQSGLSSVPMETNGLKQGSKRSRTGADSVVNAPTQDYSNSGITGVTNDQIGSEWEWDDDERGGGMDIQALLSEFGDFGDFFENDALPFGEPPGTAESQTLVFSGQDCGDGGGSPSGTLMDIQDAMLLPAGFQMFESFHSPATGMEECISTDQDATKCTSSGLVNFVPAVSSGEVDHVIKAEALLTVAPEYGAVEAPSSELSSTVFRSPYQPKSQKAESLNSSGSNYIYGATPPSSPGTNACEENTCLTADSRIHPGKHNIGSVLQKFYTQIERGQTPIDTKSFKHNNKVISSEGASLSLYSGFNSASSAKSVQNMITEVAKSAKHLLLSQQTVPSVELECLMFQAFLCRIRHTLLSFCNPASTAWKRSIGNIGMGQLPGDPSSTLENFPCKSELRKKESIPVRIAGDFDGGMLDSPFDAPMGVWRSVGTSKPAKPANTPTIEVFPSSSQHNFSEETMISYRKRQPLQDFLDAMPLLVQQAASFVDVAFDGEFVDGPYSWLALQEQWRRGFCCGPHMAHAGCGGVLASCHSFDIAGVDLLDPVSADVQASSVISLLQSDVKTALKSAFCNADGPLFVTDWCKGRSHSADAGTMIEALSAESTLSEYRDSSNTTVISMGSPVSPSQSSASMPSGLREGSKVEDACQRRLSHELRMSESELQSGLQRRPSLFVIPSSSILVGYQDDWLKTSASTLQLWEKVPLEPYAFQKHVSYYVVCPNVNPLTSGAADFFQELGSVYETCKLGSHSPHTVGNQMDVDSGKCPTSGFILLDVPRSMKVESTTATGMGSISDFYHSLSSGWDLASYLSSLAKVLKTLQLGSSLAANAKEGNSCPCTVIYVVCPFPDPNAVLKTILESSVAVSSVIFSSENGKRAMLCSQVGKALSHAAGVDEASISNIPALSGFSIPRIVLQIVPVDAIFRVTSPSLNELVLLKEIAFTVYNKARRISRGSSNEFIQSSTFSGRSSSMLVNMANPIPGMWKDCVGSRFSGPSLSREGELDPGMRAGNWDNSWQTTRAGGLSCDPNRSGDSFFQEEAHYMFEPLFILSEPGSVENGVSPMPIGGVGTDDSSGGFVQSSTLCGDTGPSSQLDGTEGDGYGSGLQKSPPSLHCCYGWTEDWRWLVCIWTDSRGELLDNHTFPFGGISSRQDTKGMQNLFVQVLQQGCQLLQACTAPDNGAARARDFVITRIGCFYELECQEWQKALYSIGGSEVKKWPLQLRRTSPDGIPTSSNGASLQQQEVERSLPSSPNPLYNLHSKSSGFMKGGLGQTTIRKQLIGGPAVVDGSRGSLQWVQSITFVSVSVDHSLHLVSQADVSTGSSQGNGITGSLNYLEGFTPVRSLGSTPASYILIPSPSMHFLTPSPLQLPTCLTSESPPLAHLLHSKGYAIPLSTGFVVSKAVPSLKKVANNLKGEWPSVISVSLVDFYGGCGVSTDKMGRALPKQAGRGVVSDAEYEVEIHSILESVMAELHALSWMTVSPAYLERRTALPFHCDMVLRLRRLLYFAEKEISHQPER
Length1944
PositionKinase
OrganismSpinacia oleracea (Spinach)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> Caryophyllales> Chenopodiaceae> Chenopodioideae> Anserineae> Spinacia.
Aromaticity0.08
Grand average of hydropathy-0.235
Instability index52.81
Isoelectric point5.46
Molecular weight208875.82
Publications
PubMed=24352233

Function

Annotated function Component of the Mediator complex, a coactivator involved in regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364134
GO - Cellular Component
mediator complex	GO:0016592	IBA:GO_Central
GO - Biological Function
transcription coregulator activity	GO:0003712	IBA:GO_Central
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IBA:GO_Central

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP04539
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      66.74|      19|     121|    1381|    1399|       1
---------------------------------------------------------------------------
 1381- 1399 (35.33/25.01)	SSNEFIQSSTFSGRS..SSML
 1499- 1519 (31.41/21.07)	SSGGFVQSSTLCGDTgpSSQL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     151.91|      52|     121|    1674|    1733|       2
---------------------------------------------------------------------------
 1674- 1733 (74.87/50.57)	LPSSPNPLYN.LHSKSSGF.MKGGLgqtTIRKQLIGGPAVVDGSRGslQWvQSItfVSVS.VD
 1799- 1853 (77.03/34.02)	LTSESPPLAHlLHSKGYAIpLSTGF...VVSKAVPSLKKVANNLKG..EW.PSV..ISVSlVD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     141.27|      30|     121|     521|     550|       3
---------------------------------------------------------------------------
  493-  521 (22.63/ 8.93)	.ER..GGGMDIQALLSEFGDFGD..........ffendalpF
  522-  550 (47.39/29.78)	GEP..PGTAESQTLVFSGQDCGDGGGSPS..GT.........
  605-  638 (37.59/21.53)	GEV..DHVIKAEALLTVAPEYG.AVEAPS..SE...lsstvF
  639-  671 (33.66/18.22)	RSPyqPKSQKAESLNSSGSNYIYGATPPSspGT.........
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     104.24|      29|     121|    1124|    1153|       4
---------------------------------------------------------------------------
 1124- 1153 (53.07/40.13)	TLQLWEKVPL...EPYAFQKHVsYYVVCPNVNP
 1246- 1277 (51.18/33.61)	TLQLGSSLAAnakEGNSCPCTV.IYVVCPFPDP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     286.38|      90|     122|     688|     780|       5
---------------------------------------------------------------------------
  688-  780 (139.94/82.54)	PGkhNIGSVLQKFYTQIE.RGQTPIDTK.SFKHNNKVISSE.GASLSLYSGFNSASSAKSVQNMITEVAKSAKHLLLSQQTVPSVElECLMFQAFL
  811-  903 (146.44/77.71)	PG..DPSSTLENFPCKSElRKKESIPVRiAGDFDGGMLDSPfDAPMGVWRSVGTSKPAKPANTPTIEVFPSSSQHNFSEETMISYR.KRQPLQDFL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      94.13|      36|      70|     358|     408|       8
---------------------------------------------------------------------------
  386-  445 (43.92/31.02)	NSLQHGLNSSSNSNNSSISSisnsssdsdcrakatsgdlegdadSLTGRQSGLS.SVPMET
  446-  487 (50.21/24.23)	NGLKQGSKRSRTGADSVVNA...................ptqdySNSGITGVTNdQIGSEW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      78.24|      27|      27|      85|     111|       9
---------------------------------------------------------------------------
   81-  109 (41.02/24.08)	WLflPGRHSSVSET.AQAAVSRLRVVASGL
  110-  138 (37.22/21.14)	WI.sPGDSEEVTTAlSQALKNRIERALIGL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      97.06|      30|     946|     330|     359|      10
---------------------------------------------------------------------------
  330-  359 (54.69/37.36)	EAVLVPVLQTSYARSSL.......KRFWLPNWTGLSL
 1278- 1314 (42.37/27.06)	NAVLKTILESSVAVSSVifssengKRAMLCSQVGKAL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     209.62|      56|     946|     224|     284|      11
---------------------------------------------------------------------------
  224-  284 (92.13/68.13)	KVTGCCPSDLVKQ....VFVGPGTSRTSTGLVGLPNP....V.AHTSGGKLRGQNYYLEVtlgcsTSGSD
  571-  600 (24.24/ 6.87)	....HSPAT.GMEecisTDQDATKC.TSSGLVNF.VP.................................
 1173- 1232 (93.25/57.37)	KLGSHSPHTVGNQ....MDVDSGKCPTS.GFILLDVPrsmkVeSTTATGMGSISDFYHSL.....SSGWD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      79.46|      20|     428|    1093|    1117|      12
---------------------------------------------------------------------------
 1093- 1117 (34.31/27.84)	SGLQRRPslfviPSSSILVGYQDDW
 1529- 1548 (45.15/25.08)	SGLQKSP.....PSLHCCYGWTEDW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      93.39|      28|     945|      41|      75|      13
---------------------------------------------------------------------------
   41-   70 (47.66/28.57)	LLSSHLQLQ.KDGFLSTWTNSFVGPWdpSQG
  987- 1015 (45.73/20.43)	LLQSDVKTAlKSAFCNADGPLFVTDW..CKG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     125.89|      40|     427|    1315|    1360|      14
---------------------------------------------------------------------------
 1315- 1360 (53.63/56.69)	SHAAGVdeasISNIPALSGFSiPRIVLQIVPVDAIFrVTSPSLNEL
 1749- 1788 (72.26/51.59)	SQGNGI....TGSLNYLEGFT.PVRSLGSTPASYIL.IPSPSMHFL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP04539 with Med13 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) DCRAKATSGDLEGDADSLTGRQSGLSSVPMETNGLKQGSKRSRTGADSVVNAPTQDYSNSGITGVTNDQIGSEWEWDDDERGGGM
2) SWYESDGNSLQHGLNSSSNSNNSSISSISNS
414
379
498
409










Molecular Recognition Features






MoRF SequenceStartStop




NANANA